Genetic variation in CYP1A1 and AHRR genes increase the risk of systemic lupus erythematosus and exacerbate disease severity in smoker patients

Background Genetic variations of aryl hydrocarbon receptor (AHR) pathway genes could influence the imbalanced immune response to xenobiotics. Therefore, we aimed to investigate the polymorphism of AHR pathway genes in systemic lupus erythematosus (SLE) patients in association with smoking. Methods G...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2021-12, Vol.35 (12), p.e22916-n/a
Hauptverfasser:	Saghaeian Jazi, Marie, Mohammadi, Saeed, Zare Ebrahimabad, Mojtaba, Sedighi, Sima, Abdolahi, Nafiseh, Tabarraei, Alijan, Yazdani, Yaghoub
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles aryl hydrocarbon receptor Autoimmune diseases Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Case-Control Studies Chronic conditions Cigarette Smoking CYP1A1 CYP1B1 gene Cytochrome P-450 CYP1A1 - genetics Cytochrome P450 Deoxyribonucleic acid DNA Environmental risk Female Gene expression Gene polymorphism Gene-Environment Interaction Genes Genetic diversity Genetic Predisposition to Disease Genetic Variation Genotype Genotyping Haplotypes Humans Immune response Leukocytes (mononuclear) Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - pathology Male Pathogenesis Peripheral blood mononuclear cells Polymorphism Repressor Proteins - genetics Repressor Proteins - metabolism Risk analysis Risk factors Severity of Illness Index Single-nucleotide polymorphism Smoking Systemic lupus erythematosus xenobiotic Xenobiotics Xenobiotics - metabolism
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