All-Trans Retinoic Acid and Doxorubicin Delivery by Folic Acid Modified Polymeric Micelles for the Modulation of Pin1-Mediated DOX-Induced Breast Cancer Stemness and Metastasis

Stemness and metastasis are the two main challenges in cancer therapy and are related to disease relapse post-treatment. They both have a strong correlation with chemoresistance and poor prognosis, ultimately leading to treatment failure. It has been reported that chemotherapy can induce stemness an...

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Veröffentlicht in:	Molecular pharmaceutics 2021-11, Vol.18 (11), p.3966-3978
Hauptverfasser:	Liu, Yupeng, Yu, Fangying, Dai, Suhuan, Meng, Tingting, Zhu, Yun, Qiu, Guoxi, Wen, Lijuan, Zhou, Xueqing, Yuan, Hong, Hu, Fuqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Apoptosis - drug effects Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Chitosan - chemistry Disease Models, Animal Doxorubicin - administration & dosage Doxorubicin - pharmacokinetics Drug Liberation Drug Synergism Female Folic Acid - chemistry Gene Knockdown Techniques Humans Mice Micelles Nanoparticle Drug Delivery System - chemistry Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology NIMA-Interacting Peptidylprolyl Isomerase - antagonists & inhibitors NIMA-Interacting Peptidylprolyl Isomerase - genetics NIMA-Interacting Peptidylprolyl Isomerase - metabolism Tissue Distribution Tretinoin - administration & dosage Tretinoin - pharmacokinetics
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