The dynamic viscoelastic characterisation and magnetic resonance imaging of poly(vinyl alcohol) cryogel: Identifying new attributes and opportunities
Poly(vinyl alcohol) (PVA) cryogel is a biocompatible, synthetic hydrogel, compatible with magnetic resonance (MR) imaging. It is widely used as a biomaterial in tissue scaffolds and mimics to test various diagnostic techniques. The aim of this study is to characterise the effect of varying PVA conce...
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| Veröffentlicht in: | Materials Science & Engineering C 2021-10, Vol.129, p.112383-112383, Article 112383 |
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| creator | Crolla, J.P. Britton, M.M. Espino, D.M. Thomas-Seale, L.E.J. |
| description | Poly(vinyl alcohol) (PVA) cryogel is a biocompatible, synthetic hydrogel, compatible with magnetic resonance (MR) imaging. It is widely used as a biomaterial in tissue scaffolds and mimics to test various diagnostic techniques. The aim of this study is to characterise the effect of varying PVA concentration, molecular weight (MW) and manufacturing protocol on the viscoelastic mechanical properties and MR T2 relaxation time. Further to this MR imaging (MRI) was investigated as a method to quantify material homogeneity. Cylindrical samples of PVA, of varying MW, concentration and number of freeze thaw cycles (FTCs), were manufactured. Dynamic mechanical analysis was performed to evaluate the storage and loss moduli between frequencies of 0.5 and 10 Hz. MR T2 relaxation maps were imaged using a 7 T MRI instrument. Storage and loss moduli were shown to increase with MW, concentration, or the number of FTCs; with storage modulus ranging from 55 kPa to 912 kPa and loss modulus ranging from 6 kPa to 103 kPa. MR T2 relaxation time was shown to increase linearly with PVA concentration. The qualitative and quantitative heterogeneity of the PVA sample were identified through MR T2 relaxation time maps. Excitingly, PVA demonstrated a composition-dependent casual correlation between the viscoelastic mechanical properties and MR T2 relaxation time. In conclusion, this research thoroughly characterised the viscoelastic mechanical properties of PVA to support its extensive use as a biomaterial, and demonstrated the use of MRI to non-invasively identify sample heterogeneity and to predict the composition-dependent viscoelastic properties of PVA.
•A range of PVA hydrogel compositions were mechanically tested and imaged with MRI.•Compositional changes were shown to impact viscoelasticity of PVA.•Non-invasive MRI was used to demonstrate changes in sample heterogeneity.•The casual correlation between viscoelasticity and MR relaxation time was explored. |
| doi_str_mv | 10.1016/j.msec.2021.112383 |
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•A range of PVA hydrogel compositions were mechanically tested and imaged with MRI.•Compositional changes were shown to impact viscoelasticity of PVA.•Non-invasive MRI was used to demonstrate changes in sample heterogeneity.•The casual correlation between viscoelasticity and MR relaxation time was explored.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2021.112383</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Biocompatibility ; Biomaterials ; Biomedical materials ; Composition ; Dynamic mechanical analysis ; Freeze thaw cycles ; Freeze-thawing ; Heterogeneity ; Homogeneity ; Hydrogels ; Loss Modulus ; Magnetic resonance imaging ; Materials science ; Mechanical properties ; Medical imaging ; Molecular weight ; MRI ; Polyvinyl alcohol ; PVA ; Relaxation time ; Resonance ; Storage modulus ; Viscoelasticity</subject><ispartof>Materials Science & Engineering C, 2021-10, Vol.129, p.112383-112383, Article 112383</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright Elsevier BV Oct 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-c84f2da59017476148082c789165e916903a3ce3c824a6392cf921500ea80efb3</citedby><cites>FETCH-LOGICAL-c405t-c84f2da59017476148082c789165e916903a3ce3c824a6392cf921500ea80efb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.msec.2021.112383$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Crolla, J.P.</creatorcontrib><creatorcontrib>Britton, M.M.</creatorcontrib><creatorcontrib>Espino, D.M.</creatorcontrib><creatorcontrib>Thomas-Seale, L.E.J.</creatorcontrib><title>The dynamic viscoelastic characterisation and magnetic resonance imaging of poly(vinyl alcohol) cryogel: Identifying new attributes and opportunities</title><title>Materials Science & Engineering C</title><description>Poly(vinyl alcohol) (PVA) cryogel is a biocompatible, synthetic hydrogel, compatible with magnetic resonance (MR) imaging. It is widely used as a biomaterial in tissue scaffolds and mimics to test various diagnostic techniques. The aim of this study is to characterise the effect of varying PVA concentration, molecular weight (MW) and manufacturing protocol on the viscoelastic mechanical properties and MR T2 relaxation time. Further to this MR imaging (MRI) was investigated as a method to quantify material homogeneity. Cylindrical samples of PVA, of varying MW, concentration and number of freeze thaw cycles (FTCs), were manufactured. Dynamic mechanical analysis was performed to evaluate the storage and loss moduli between frequencies of 0.5 and 10 Hz. MR T2 relaxation maps were imaged using a 7 T MRI instrument. Storage and loss moduli were shown to increase with MW, concentration, or the number of FTCs; with storage modulus ranging from 55 kPa to 912 kPa and loss modulus ranging from 6 kPa to 103 kPa. MR T2 relaxation time was shown to increase linearly with PVA concentration. The qualitative and quantitative heterogeneity of the PVA sample were identified through MR T2 relaxation time maps. Excitingly, PVA demonstrated a composition-dependent casual correlation between the viscoelastic mechanical properties and MR T2 relaxation time. In conclusion, this research thoroughly characterised the viscoelastic mechanical properties of PVA to support its extensive use as a biomaterial, and demonstrated the use of MRI to non-invasively identify sample heterogeneity and to predict the composition-dependent viscoelastic properties of PVA.
•A range of PVA hydrogel compositions were mechanically tested and imaged with MRI.•Compositional changes were shown to impact viscoelasticity of PVA.•Non-invasive MRI was used to demonstrate changes in sample heterogeneity.•The casual correlation between viscoelasticity and MR relaxation time was explored.</description><subject>Biocompatibility</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Composition</subject><subject>Dynamic mechanical analysis</subject><subject>Freeze thaw cycles</subject><subject>Freeze-thawing</subject><subject>Heterogeneity</subject><subject>Homogeneity</subject><subject>Hydrogels</subject><subject>Loss Modulus</subject><subject>Magnetic resonance imaging</subject><subject>Materials science</subject><subject>Mechanical properties</subject><subject>Medical imaging</subject><subject>Molecular weight</subject><subject>MRI</subject><subject>Polyvinyl alcohol</subject><subject>PVA</subject><subject>Relaxation time</subject><subject>Resonance</subject><subject>Storage modulus</subject><subject>Viscoelasticity</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u3CAUhVHVSp2meYGskLpJF57yZxuqbqooaSJF6iZdI4KvZxgx4AKeyg_S9y3udNVFNiDgO5d7z0HoipItJbT7dNgeM9gtI4xuKWVc8ldoQ2XPG0IVfY02RDHZCMXpW_Qu5wMhneQ926DfT3vAwxLM0Vl8ctlG8CaXerB7k4wtkFw2xcWATRjw0ewCrK8JcgwmWMCu3rmww3HEU_TL9cmFxWPjbdxH_xHbtMQd-M_4YYBQ3LisbIBf2JSS3PNcIP-tHKcppjIHVxzk9-jNaHyGy3_7Bfpxd_t0c988fv_2cPP1sbGCtKWxUoxsMK0itBd9R4UkktleKtq1UBdFuOEWuJVMmI4rZkfFaEsIGElgfOYX6Ppcd0rx5wy56GO1ALw3AeKcNWv7XgjFWlXRD_-hhzinULurlGxF_bXrK8XOlE0x5wSjnlI1KC2aEr0mpQ96TUqvSelzUlX05SyCOurJQdLZOqjeDi6BLXqI7iX5H5PHnrI</recordid><startdate>202110</startdate><enddate>202110</enddate><creator>Crolla, J.P.</creator><creator>Britton, M.M.</creator><creator>Espino, D.M.</creator><creator>Thomas-Seale, L.E.J.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202110</creationdate><title>The dynamic viscoelastic characterisation and magnetic resonance imaging of poly(vinyl alcohol) cryogel: Identifying new attributes and opportunities</title><author>Crolla, J.P. ; Britton, M.M. ; Espino, D.M. ; Thomas-Seale, L.E.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-c84f2da59017476148082c789165e916903a3ce3c824a6392cf921500ea80efb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biocompatibility</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Composition</topic><topic>Dynamic mechanical analysis</topic><topic>Freeze thaw cycles</topic><topic>Freeze-thawing</topic><topic>Heterogeneity</topic><topic>Homogeneity</topic><topic>Hydrogels</topic><topic>Loss Modulus</topic><topic>Magnetic resonance imaging</topic><topic>Materials science</topic><topic>Mechanical properties</topic><topic>Medical imaging</topic><topic>Molecular weight</topic><topic>MRI</topic><topic>Polyvinyl alcohol</topic><topic>PVA</topic><topic>Relaxation time</topic><topic>Resonance</topic><topic>Storage modulus</topic><topic>Viscoelasticity</topic><toplevel>online_resources</toplevel><creatorcontrib>Crolla, J.P.</creatorcontrib><creatorcontrib>Britton, M.M.</creatorcontrib><creatorcontrib>Espino, D.M.</creatorcontrib><creatorcontrib>Thomas-Seale, L.E.J.</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crolla, J.P.</au><au>Britton, M.M.</au><au>Espino, D.M.</au><au>Thomas-Seale, L.E.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The dynamic viscoelastic characterisation and magnetic resonance imaging of poly(vinyl alcohol) cryogel: Identifying new attributes and opportunities</atitle><jtitle>Materials Science & Engineering C</jtitle><date>2021-10</date><risdate>2021</risdate><volume>129</volume><spage>112383</spage><epage>112383</epage><pages>112383-112383</pages><artnum>112383</artnum><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Poly(vinyl alcohol) (PVA) cryogel is a biocompatible, synthetic hydrogel, compatible with magnetic resonance (MR) imaging. It is widely used as a biomaterial in tissue scaffolds and mimics to test various diagnostic techniques. The aim of this study is to characterise the effect of varying PVA concentration, molecular weight (MW) and manufacturing protocol on the viscoelastic mechanical properties and MR T2 relaxation time. Further to this MR imaging (MRI) was investigated as a method to quantify material homogeneity. Cylindrical samples of PVA, of varying MW, concentration and number of freeze thaw cycles (FTCs), were manufactured. Dynamic mechanical analysis was performed to evaluate the storage and loss moduli between frequencies of 0.5 and 10 Hz. MR T2 relaxation maps were imaged using a 7 T MRI instrument. Storage and loss moduli were shown to increase with MW, concentration, or the number of FTCs; with storage modulus ranging from 55 kPa to 912 kPa and loss modulus ranging from 6 kPa to 103 kPa. MR T2 relaxation time was shown to increase linearly with PVA concentration. The qualitative and quantitative heterogeneity of the PVA sample were identified through MR T2 relaxation time maps. Excitingly, PVA demonstrated a composition-dependent casual correlation between the viscoelastic mechanical properties and MR T2 relaxation time. In conclusion, this research thoroughly characterised the viscoelastic mechanical properties of PVA to support its extensive use as a biomaterial, and demonstrated the use of MRI to non-invasively identify sample heterogeneity and to predict the composition-dependent viscoelastic properties of PVA.
•A range of PVA hydrogel compositions were mechanically tested and imaged with MRI.•Compositional changes were shown to impact viscoelasticity of PVA.•Non-invasive MRI was used to demonstrate changes in sample heterogeneity.•The casual correlation between viscoelasticity and MR relaxation time was explored.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.msec.2021.112383</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biocompatibility Biomaterials Biomedical materials Composition Dynamic mechanical analysis Freeze thaw cycles Freeze-thawing Heterogeneity Homogeneity Hydrogels Loss Modulus Magnetic resonance imaging Materials science Mechanical properties Medical imaging Molecular weight MRI Polyvinyl alcohol PVA Relaxation time Resonance Storage modulus Viscoelasticity |
| title | The dynamic viscoelastic characterisation and magnetic resonance imaging of poly(vinyl alcohol) cryogel: Identifying new attributes and opportunities |
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