The Role of Release Factors in the Hydrolysis of Ester Bond in Peptidyl-tRNA

Class I release factors (RFs) recognize stop codons in the sequences of mRNAs and are required for the hydrolysis of peptidyl-tRNA in the ribosomal P site during the final step of protein synthesis in bacteria, resulting in the release of a complete polypeptide chain from the ribosome. A key role in...

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Veröffentlicht in:	Biochemistry (Moscow) 2021-09, Vol.86 (9), p.1122-1127
Hauptverfasser:	Balasanyants, Samson M., Aleksandrova, Elena V., Polikanov, Yury S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Carbonyl compounds Carbonyl groups Carbonyls Catalysis Codon Codons Glutamine Hydrolysis Life Sciences Microbiology Mini-Review Mutation Polypeptides Protein biosynthesis Protein synthesis Transfer RNA tRNA Water chemistry
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