STRATIFICATION OF POTENCY OUTCOMES FOLLOWING ROBOT-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY BASED ON AGE, PREOPERATIVE POTENCY AND NERVE SPARING (NS)
Introduction To identify factors affecting potency and to predict ideal patient subgroups who will have the highest chance of being potent post RALP based on NS. Materials and methods Analysis of 7268 patients that underwent RALP between 2008-2018 with a minimum of 12 months follow-up was performed....
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| Veröffentlicht in: | Journal of endourology 2021-11, Vol.35 (11), p.1631-1638 |
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| creator | Bhat, Seetharam Kulthe Ramesh Covas Moschovas, Marcio Sandri, Marco Reddy, Sunil Onol, Fikret Noel, Jonathan Rogers, Travis Phillip Schatloff, Oscar Coelho, Rafael Ferreira Ko, Young Hwii Roof, Shannon Rocco, Bernardo Maria Cesare Patel, Vipul |
| description | Introduction To identify factors affecting potency and to predict ideal patient subgroups who will have the highest chance of being potent post RALP based on NS. Materials and methods Analysis of 7268 patients that underwent RALP between 2008-2018 with a minimum of 12 months follow-up was performed. The patients were then categorized into 4 separate Neurovascular Bundle sparing groups (NVB 1-4). A Cox regression analysis was used to determine the independent factors predicting potency outcomes. Cumulative Incidence Functions (CIFs) were used to depict the probability and time to potency between the NS groups stratified by age and preoperative SHIM. Results Cox regression analysis of age, pre-operative SHIM score, and grades of NS significantly predicted potency outcomes post RALP. Patients with SHIM score ≥22 had a better chance of potency vs patients with SHIM |
| doi_str_mv | 10.1089/end.2021.0141 |
| format | Article |
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Materials and methods Analysis of 7268 patients that underwent RALP between 2008-2018 with a minimum of 12 months follow-up was performed. The patients were then categorized into 4 separate Neurovascular Bundle sparing groups (NVB 1-4). A Cox regression analysis was used to determine the independent factors predicting potency outcomes. Cumulative Incidence Functions (CIFs) were used to depict the probability and time to potency between the NS groups stratified by age and preoperative SHIM. Results Cox regression analysis of age, pre-operative SHIM score, and grades of NS significantly predicted potency outcomes post RALP. Patients with SHIM score ≥22 had a better chance of potency vs patients with SHIM<17 (OR-1.69, CI-1.47-1.79). NVB1 had better potency vs NVB4 (OR -3.1, CI- 2.51-3.83). Patients <55 yrs with NVB1 and no pre-operative ED had the best potency rates of 92.5%. However, we did not see any statistical difference between NVB2 and NVB3 in this group, implying that in patient groups with SHIM ≥22 and age<55, NVB1 provided the best chance of potency recovery. As age increased and preoperative SHIM worsened, the curves corresponding to NVB 2 and 3 showed significant differences, suggesting that NVB 2 and 3 may be predictive in unfavorable age and preoperative SHIM groups, especially NVB 2 > NVB 3. Conclusions Preoperative SHIM, age and NS are the most influential factors for potency recovery following RALP. Patients with good baseline sexual function had similar post-operative potency, irrespective of their grades of partial NS. In patients with decreased baseline SHIM and older age, a higher grade of partial NS resulted in significantly better potency compared to a lower grade of partial nerve spare.</description><identifier>ISSN: 0892-7790</identifier><identifier>EISSN: 1557-900X</identifier><identifier>DOI: 10.1089/end.2021.0141</identifier><identifier>PMID: 33947270</identifier><language>eng</language><publisher>United States</publisher><ispartof>Journal of endourology, 2021-11, Vol.35 (11), p.1631-1638</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c241t-a8054f24d8a28fb1cd1a3c7ea170825e9995e8e1b8fca8e3f3b576a8e34835af3</citedby><cites>FETCH-LOGICAL-c241t-a8054f24d8a28fb1cd1a3c7ea170825e9995e8e1b8fca8e3f3b576a8e34835af3</cites><orcidid>0000-0003-3404-993X ; 0000-0003-3126-4829 ; 0000-0002-3290-7323 ; 0000-0002-9135-0035</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33947270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhat, Seetharam Kulthe Ramesh</creatorcontrib><creatorcontrib>Covas Moschovas, Marcio</creatorcontrib><creatorcontrib>Sandri, Marco</creatorcontrib><creatorcontrib>Reddy, Sunil</creatorcontrib><creatorcontrib>Onol, Fikret</creatorcontrib><creatorcontrib>Noel, Jonathan</creatorcontrib><creatorcontrib>Rogers, Travis Phillip</creatorcontrib><creatorcontrib>Schatloff, Oscar</creatorcontrib><creatorcontrib>Coelho, Rafael Ferreira</creatorcontrib><creatorcontrib>Ko, Young Hwii</creatorcontrib><creatorcontrib>Roof, Shannon</creatorcontrib><creatorcontrib>Rocco, Bernardo Maria Cesare</creatorcontrib><creatorcontrib>Patel, Vipul</creatorcontrib><title>STRATIFICATION OF POTENCY OUTCOMES FOLLOWING ROBOT-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY BASED ON AGE, PREOPERATIVE POTENCY AND NERVE SPARING (NS)</title><title>Journal of endourology</title><addtitle>J Endourol</addtitle><description>Introduction To identify factors affecting potency and to predict ideal patient subgroups who will have the highest chance of being potent post RALP based on NS. Materials and methods Analysis of 7268 patients that underwent RALP between 2008-2018 with a minimum of 12 months follow-up was performed. The patients were then categorized into 4 separate Neurovascular Bundle sparing groups (NVB 1-4). A Cox regression analysis was used to determine the independent factors predicting potency outcomes. Cumulative Incidence Functions (CIFs) were used to depict the probability and time to potency between the NS groups stratified by age and preoperative SHIM. Results Cox regression analysis of age, pre-operative SHIM score, and grades of NS significantly predicted potency outcomes post RALP. Patients with SHIM score ≥22 had a better chance of potency vs patients with SHIM<17 (OR-1.69, CI-1.47-1.79). NVB1 had better potency vs NVB4 (OR -3.1, CI- 2.51-3.83). Patients <55 yrs with NVB1 and no pre-operative ED had the best potency rates of 92.5%. However, we did not see any statistical difference between NVB2 and NVB3 in this group, implying that in patient groups with SHIM ≥22 and age<55, NVB1 provided the best chance of potency recovery. As age increased and preoperative SHIM worsened, the curves corresponding to NVB 2 and 3 showed significant differences, suggesting that NVB 2 and 3 may be predictive in unfavorable age and preoperative SHIM groups, especially NVB 2 > NVB 3. Conclusions Preoperative SHIM, age and NS are the most influential factors for potency recovery following RALP. Patients with good baseline sexual function had similar post-operative potency, irrespective of their grades of partial NS. In patients with decreased baseline SHIM and older age, a higher grade of partial NS resulted in significantly better potency compared to a lower grade of partial nerve spare.</description><issn>0892-7790</issn><issn>1557-900X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkbtOwzAUhi0EgnIZWZFHkEjxLcQeTeqWSCGOYnObIjd1JFBLIaEDb8Lj4ojLzOJjnfPp-4cfgGOMxhhxceFfFmOCCB4jzPAWGOE4TiKB0MM2GIU7iZJEoD2w3_fPCGF6ieku2KNUsIQkaAQ-ja2kzaZZGl5dQD2FpbaqSB-hvrWpvlEGTnWe6_usmMFKX2kbSWMyY9UE5rKUlTapLrMUVnISJDksw8ZKq1Krbx7hlTQBDGI5U-fhpnSphsA79ZcjiwksVBU2JuiGmNPCnB2CndYte3_0Mw_A7VTZ9DrK9WzIiRrC8HvkOIpZS9iCO8LbOW4W2NEm8Q4niJPYCyFizz2e87Zx3NOWzuPkcvgxTmPX0gNw-u197dZvG9-_16unvvHLpXvx601fk4ALzBil_0AJoYILhgMafaNNt-77zrf1a_e0ct1HjVE99FaH3uqht3roLfAnP-rNfOUXf_RvUfQLt3KHYg</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Bhat, Seetharam Kulthe Ramesh</creator><creator>Covas Moschovas, Marcio</creator><creator>Sandri, Marco</creator><creator>Reddy, Sunil</creator><creator>Onol, Fikret</creator><creator>Noel, Jonathan</creator><creator>Rogers, Travis Phillip</creator><creator>Schatloff, Oscar</creator><creator>Coelho, Rafael Ferreira</creator><creator>Ko, Young Hwii</creator><creator>Roof, Shannon</creator><creator>Rocco, Bernardo Maria Cesare</creator><creator>Patel, Vipul</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3404-993X</orcidid><orcidid>https://orcid.org/0000-0003-3126-4829</orcidid><orcidid>https://orcid.org/0000-0002-3290-7323</orcidid><orcidid>https://orcid.org/0000-0002-9135-0035</orcidid></search><sort><creationdate>20211101</creationdate><title>STRATIFICATION OF POTENCY OUTCOMES FOLLOWING ROBOT-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY BASED ON AGE, PREOPERATIVE POTENCY AND NERVE SPARING (NS)</title><author>Bhat, Seetharam Kulthe Ramesh ; Covas Moschovas, Marcio ; Sandri, Marco ; Reddy, Sunil ; Onol, Fikret ; Noel, Jonathan ; Rogers, Travis Phillip ; Schatloff, Oscar ; Coelho, Rafael Ferreira ; Ko, Young Hwii ; Roof, Shannon ; Rocco, Bernardo Maria Cesare ; Patel, Vipul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-a8054f24d8a28fb1cd1a3c7ea170825e9995e8e1b8fca8e3f3b576a8e34835af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhat, Seetharam Kulthe Ramesh</creatorcontrib><creatorcontrib>Covas Moschovas, Marcio</creatorcontrib><creatorcontrib>Sandri, Marco</creatorcontrib><creatorcontrib>Reddy, Sunil</creatorcontrib><creatorcontrib>Onol, Fikret</creatorcontrib><creatorcontrib>Noel, Jonathan</creatorcontrib><creatorcontrib>Rogers, Travis Phillip</creatorcontrib><creatorcontrib>Schatloff, Oscar</creatorcontrib><creatorcontrib>Coelho, Rafael Ferreira</creatorcontrib><creatorcontrib>Ko, Young Hwii</creatorcontrib><creatorcontrib>Roof, Shannon</creatorcontrib><creatorcontrib>Rocco, Bernardo Maria Cesare</creatorcontrib><creatorcontrib>Patel, Vipul</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endourology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhat, Seetharam Kulthe Ramesh</au><au>Covas Moschovas, Marcio</au><au>Sandri, Marco</au><au>Reddy, Sunil</au><au>Onol, Fikret</au><au>Noel, Jonathan</au><au>Rogers, Travis Phillip</au><au>Schatloff, Oscar</au><au>Coelho, Rafael Ferreira</au><au>Ko, Young Hwii</au><au>Roof, Shannon</au><au>Rocco, Bernardo Maria Cesare</au><au>Patel, Vipul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STRATIFICATION OF POTENCY OUTCOMES FOLLOWING ROBOT-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY BASED ON AGE, PREOPERATIVE POTENCY AND NERVE SPARING (NS)</atitle><jtitle>Journal of endourology</jtitle><addtitle>J Endourol</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>35</volume><issue>11</issue><spage>1631</spage><epage>1638</epage><pages>1631-1638</pages><issn>0892-7790</issn><eissn>1557-900X</eissn><abstract>Introduction To identify factors affecting potency and to predict ideal patient subgroups who will have the highest chance of being potent post RALP based on NS. Materials and methods Analysis of 7268 patients that underwent RALP between 2008-2018 with a minimum of 12 months follow-up was performed. The patients were then categorized into 4 separate Neurovascular Bundle sparing groups (NVB 1-4). A Cox regression analysis was used to determine the independent factors predicting potency outcomes. Cumulative Incidence Functions (CIFs) were used to depict the probability and time to potency between the NS groups stratified by age and preoperative SHIM. Results Cox regression analysis of age, pre-operative SHIM score, and grades of NS significantly predicted potency outcomes post RALP. Patients with SHIM score ≥22 had a better chance of potency vs patients with SHIM<17 (OR-1.69, CI-1.47-1.79). NVB1 had better potency vs NVB4 (OR -3.1, CI- 2.51-3.83). Patients <55 yrs with NVB1 and no pre-operative ED had the best potency rates of 92.5%. However, we did not see any statistical difference between NVB2 and NVB3 in this group, implying that in patient groups with SHIM ≥22 and age<55, NVB1 provided the best chance of potency recovery. As age increased and preoperative SHIM worsened, the curves corresponding to NVB 2 and 3 showed significant differences, suggesting that NVB 2 and 3 may be predictive in unfavorable age and preoperative SHIM groups, especially NVB 2 > NVB 3. Conclusions Preoperative SHIM, age and NS are the most influential factors for potency recovery following RALP. Patients with good baseline sexual function had similar post-operative potency, irrespective of their grades of partial NS. In patients with decreased baseline SHIM and older age, a higher grade of partial NS resulted in significantly better potency compared to a lower grade of partial nerve spare.</abstract><cop>United States</cop><pmid>33947270</pmid><doi>10.1089/end.2021.0141</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3404-993X</orcidid><orcidid>https://orcid.org/0000-0003-3126-4829</orcidid><orcidid>https://orcid.org/0000-0002-3290-7323</orcidid><orcidid>https://orcid.org/0000-0002-9135-0035</orcidid></addata></record> |
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| title | STRATIFICATION OF POTENCY OUTCOMES FOLLOWING ROBOT-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY BASED ON AGE, PREOPERATIVE POTENCY AND NERVE SPARING (NS) |
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