Shutting the gate: targeting endocytosis in acute leukemia
•Niche signals support leukemia development, while driving progression and relapse.•Endocytosis controls cellular processes that are essential in leukemia.•Targeting endocytosis represents a novel therapeutic strategy for acute leukemia. Endocytosis entails selective packaging of cell surface cargos...
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| Veröffentlicht in: | Experimental hematology 2021-12, Vol.104, p.17-31 |
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| container_title | Experimental hematology |
| container_volume | 104 |
| creator | Tremblay, Cedric S. Ting, Stephen B. McCluskey, Adam Robinson, Phillip J. Curtis, David J. |
| description | •Niche signals support leukemia development, while driving progression and relapse.•Endocytosis controls cellular processes that are essential in leukemia.•Targeting endocytosis represents a novel therapeutic strategy for acute leukemia.
Endocytosis entails selective packaging of cell surface cargos in cytoplasmic vesicles, thereby controlling key intrinsic cellular processes as well as the response of normal and malignant cells to their microenvironment. The purpose of this review is to outline the latest advances in the development of endocytosis-targeting therapeutic strategies in hematological malignancies. |
| doi_str_mv | 10.1016/j.exphem.2021.09.003 |
| format | Article |
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| ispartof | Experimental hematology, 2021-12, Vol.104, p.17-31 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Endocytosis - drug effects Hematologic Neoplasms - drug therapy Hematologic Neoplasms - pathology Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Molecular Targeted Therapy - methods Tumor Microenvironment - drug effects |
| title | Shutting the gate: targeting endocytosis in acute leukemia |
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