Immunoinformatics and molecular docking studies reveal a novel Multi-Epitope peptide vaccine against pneumonia infection

[Display omitted] •Type 3 fimbrial protein (mrkA) protein plays a major determinant in the virulence of K. pneumoniae.•Immunoinformatic approaches was employed to design a novel multi-peptide vaccine to induce humoral and cellular immune responses.•Immunological potential including the allergenicity...

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Veröffentlicht in:	Vaccine 2021-10, Vol.39 (42), p.6221-6237
Hauptverfasser:	Mahapatra, Soumya Ranjan, Dey, Jyotirmayee, Kaur, Taranjeet, Sarangi, Rajlaxmi, Bajoria, Atul Anand, Kushwaha, Gajraj Singh, Misra, Namrata, Suar, Mrutyunjay
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Allergenicity Amino acids Antibiotics Antigenicity Antigens Bacterial infections Biofilms Chemical compounds Cross-reactivity Cytotoxicity Epitopes Fimbrial protein Immunodominance Immunogenicity Immunoinformatics Immunology Klebsiella Klebsiella pneumoniae Lymphocytes Lymphocytes T Molecular docking Multi-epitope vaccine Neural networks Nosocomial infections Pathogens Peptides Pharmacology Physicochemical properties Pilin Pneumonia Prevention Protein purification Protein structure Proteins Proteomes Servers Stability analysis Tertiary structure TLR2 protein Toll-like receptors Toxicity Vaccine development Vaccines
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