Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways

Objective This study aimed to investigate the biochemical effects of osteoarthritic infrapatellar fat pad (IPFP) on cartilage and the underlying mechanisms. Methods Human IPFP and articular cartilage were collected from end-stage osteoarthritis (OA) patients during total knee arthroplasty. IPFP-deri...

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Veröffentlicht in:	Inflammation research 2021-12, Vol.70 (10-12), p.1129-1139
Hauptverfasser:	Zhou, Zuoqing, Tang, Su’an, Nie, Xiaoyu, Zhang, Yiqun, Li, Delong, Zhao, Yang, Cao, Yumei, Yin, Jianwen, Chen, Tianyu, Ruan, Guangfeng, Zhu, Zhaohua, Bai, Xiaochun, Han, Weiyu, Ding, Changhai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - immunology Allergology Arthroplasty (knee) Biomedical and Life Sciences Biomedical materials Biomedicine Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - immunology Cells, Cultured Chondrocytes Chondrocytes - immunology Cytokines - immunology Degradation Dermatology Explants Extracellular matrix Extracellular signal-regulated kinase Humans IL-1β Immunoblotting Immunology Interleukin 6 Kinases Knee MAP Kinase Signaling System Neurology Neutralization NF-κB protein Original Research Paper Osteoarthritis Osteoarthritis, Knee - immunology p38 Mitogen-Activated Protein Kinases - immunology Patella - immunology Pharmacology/Toxicology Rheumatology Signal transduction Signaling Tumor necrosis factor-α
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