PAF Receptor Inhibition Attenuates Neuronal Pyroptosis in Cerebral Ischemia/Reperfusion Injury

Ischemic stroke is an inflammation-related disease, during which process activation of NLRP3 inflammasome and subsequent pyroptosis play crucial roles. Platelet-activating factor (PAF) is a potent phospholipid regulator of inflammation which exerts its effect via binding specific PAF receptor (PAFR)...

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Veröffentlicht in:	Molecular neurobiology 2021-12, Vol.58 (12), p.6520-6539
Hauptverfasser:	Zhao, Bo, Fei, Yuxiang, Zhu, Jianping, Yin, Qiyang, Fang, Weirong, Li, Yunman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Cerebral blood flow Disease Models, Animal Ginkgolides - pharmacology Inflammasomes Inflammasomes - metabolism Inflammation Ischemia Lactones - pharmacology Lipopolysaccharides Male Mice Neurobiology Neurology Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Nigericin Phospholipids Platelet Membrane Glycoproteins - antagonists & inhibitors Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - metabolism Platelet-activating factor Pyroptosis Pyroptosis - drug effects Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Reperfusion Reperfusion Injury - metabolism siRNA Stroke
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