M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

M2-polarized, pro-tumoral tumor-associated macrophages (TAMs) express the interleukin-4 receptor (IL4R) at higher levels compared with M1-polarized, anti-tumoral macrophages. In this study, we harnessed M1 macrophage-derived exosomes engineered to foster M1 polarization and target IL4R for the inhib...

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Veröffentlicht in:	Biomaterials 2021-11, Vol.278, p.121137-121137, Article 121137
Hauptverfasser:	Gunassekaran, Gowri Rangaswamy, Poongkavithai Vadevoo, Sri Murugan, Baek, Moon-Chang, Lee, Byungheon
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular Reprogramming Exosome Exosomes Humans Interleukin-4 receptor Interleukin-4 Receptor alpha Subunit M1 macrophage M2 macrophage Macrophages miR-511–3p Neoplasms - therapy NF-κB p50 Receptors, Interleukin-4 Tumor-associated macrophage Tumor-Associated Macrophages
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