Adiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord

[Display omitted] •The deletion of APN significantly reduces EA analgesia.•Intrathecal administration of APN mimics the analgesic effects of EA.•EA increases APN accumulation in the spinal cord coming from blood vessels.•Spinal adipoR2 dominantly mediates APN- and EA-produced analgesic effects.•Spin...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2022-01, Vol.99, p.43-52
Hauptverfasser:	Ning, Zhipeng, Gu, Pan, Zhang, Jialing, Cheung, Chi Wai, Lao, Lixing, Chen, Haiyong, Zhang, Zhang-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	acupuncture analgesia Adiponectin AdipoR AMPK Analgesics Animals Electroacupuncture Mice pain Pain Management Rats Rats, Sprague-Dawley Spinal Cord - metabolism
Online-Zugang:	Volltext
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