Brain regions susceptible to alpha-synuclein spreading

The spreading of misfolded alpha-synuclein (α-syn) protein has been observed in animal models of Parkinson’s disease (PD) and other α-synucleinopathies that mimic human PD pathologies. In animal models, the spreading of α-syn has been associated with motor dysfunction and neuronal death. However, va...

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Veröffentlicht in:	Molecular psychiatry 2022-01, Vol.27 (1), p.758-770
Hauptverfasser:	Guo, Yu-Jie, Xiong, Huan, Chen, Kang, Zou, Jin-Jun, Lei, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378 692/699 alpha-Synuclein - metabolism Animal models Animals Autopsy Behavioral Sciences Biological Psychology Brain Brain - metabolism Disease Models, Animal Inoculation Medicine Medicine & Public Health Movement disorders Neurodegenerative diseases Neurosciences Parkinson Disease - metabolism Parkinson's disease Pharmacotherapy Protein folding Psychiatry Review Article Reviews Spreading Synuclein Synucleinopathies
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