The mechanisms of integral membrane protein biogenesis

Roughly one quarter of all genes code for integral membrane proteins that are inserted into the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of eukaryotes. Multiple pathways are used for the targeting and insertion of membrane proteins on the basis of their topological and bi...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2022-02, Vol.23 (2), p.107-124
Hauptverfasser:	Hegde, Ramanujan S., Keenan, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/470/1463 631/45/470/1981 631/80/2023/2022 Animals Assembly Biochemistry Biomedical and Life Sciences Biosynthesis Cancer Research Cell Biology Developmental Biology Endoplasmic reticulum Endoplasmic Reticulum - metabolism Eukaryotes Folding Humans Insertion Integral membrane proteins Life Sciences Lipid bilayers Lipids Membrane Proteins - chemistry Membrane Proteins - metabolism Membranes Models, Molecular Prokaryotes Protein Biosynthesis Proteins Proteomes Review Article Signal Recognition Particle - metabolism Stem Cells Structure-function relationships Substrate Specificity Topology
Online-Zugang:	Volltext
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