Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8+ T lymphocytes

•IL-36α is negatively associated with tumor distal metastasis and TNM stage in CRC.•Overexpression of IL-36α could inhibit the growth and metastasis of CRC cells.•The proliferation and function of CD8+ T lymphocytes is increased in CT26-IL-36α tumor. Colorectal cancer is one of the deadliest cancers...

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Veröffentlicht in:	International immunopharmacology 2021-11, Vol.100, p.108152-108152, Article 108152
Hauptverfasser:	Wei, Xiuyu, Yao, Yongjie, Wang, Xiaoxi, Sun, Jiaxin, Zhao, Wenshan, Qiu, Lu, Zhai, Wenjie, Qi, Yuanming, Gao, Yanfeng, Wu, Yahong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - secondary Animal models Animals Anticancer properties Antitumor activity Biomarkers Cancer CD3 antigen CD8 antigen CD8+ T lymphocytes CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Movement Cell Proliferation Chemical compounds Chemokine CXCL10 - metabolism Chemokine CXCL11 - metabolism Coculture Techniques Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology CXCL10 protein CXCL11 protein Cytokines Databases, Genetic Female Gene Expression Regulation, Neoplastic HT29 Cells Humans Immune response Immune system Immunology Infiltration Inflammation Inflammatory response Interleukin-1 - genetics Interleukin-1 - metabolism Interleukin-36α Interleukins Leukocyte migration Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - secondary Lungs Lymph nodes Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Male Metastases Metastasis Mice Mice, Inbred BALB C Middle Aged Neoplasm Invasiveness Pharmacology Signal Transduction Spleen Tumor immunology Tumor Microenvironment Tumors
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