Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats
Background Early postnatal overfeeding (PO) induces long-term overweight and reduces brown adipose tissue (BAT) thermogenesis. Exercise has been suggested as a possible intervention to increase BAT function. In this study, we investigated chronical effects of moderate-intensity exercise in BAT funct...
Gespeichert in:
| Veröffentlicht in: | International Journal of Obesity 2022-01, Vol.46 (1), p.137-143 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 143 |
|---|---|
| container_issue | 1 |
| container_start_page | 137 |
| container_title | International Journal of Obesity |
| container_volume | 46 |
| creator | Almeida, Douglas Lopes Moreira, Veridiana Mota Cardoso, Lucas Eduardo Junior, Marcos Divino Ferreira Pavanelo, Audrei Ribeiro, Tatiane Aparecida da Silva Franco, Claudinéia Conationi Tófolo, Laize Perón Peres, Maria Natália Chimirri Ribeiro, Maiara Vanusa Guedes Ferreira, Anna Rebeka Oliveira Gomes, Rodrigo Mello Miranda, Rosiane Aparecida Trevenzoli, Isis Hara Armitage, James Andrew Palma-Rigo, Kesia de Freitas Mathias, Paulo Cesar |
| description | Background
Early postnatal overfeeding (PO) induces long-term overweight and reduces brown adipose tissue (BAT) thermogenesis. Exercise has been suggested as a possible intervention to increase BAT function. In this study, we investigated chronical effects of moderate-intensity exercise in BAT function in postnatal overfed male Wistar rats
Methods
Litters’ delivery was on postnatal-day 0 - PN0. At PN2, litters were adjusted to nine (normal litter – NL) or three pups (small litter – SL) per dam. Animals were weaned on PN21 and in PN30 randomly divided into sedentary (NL-Sed and SL-Sed) or exercised (NL-Exe and SL-Exe), N of 14 litters per group. Exercise protocol started (PN30) with an effort test; training sessions were performed three times weekly at 60% of the VO
2max
achieved in effort test, until PN80. On PN81, a temperature transponder was implanted beneath the interscapular BAT, whose temperature was assessed in periods of lights-on and -off from PN87 to PN90. Sympathetic nerve activation of BAT was registered at PN90. Animals were euthanized at PN91 and tissues collected
Results
PO impaired BAT thermogenesis in lights-on (
p
PO
|
| doi_str_mv | 10.1038/s41366-021-00969-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2575838645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2618381368</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-8c70b149e754c77e76e149650291e9a3461e0fd76a53f4488fc753b5f2b8fec43</originalsourceid><addsrcrecordid>eNp9kctO5DAQRS0Egh7gB1ggS7NhMQE7fiWzQwgGpJbYgFhaTlJmgpK4cSUDLX4eNw2DxIKVH3XudZUvIQecHXMmihOUXGidsZxnjJW6zPgGmXFpdKZkaTbJjAlmMqa02iE_EB8YY0qxfJvsCKlUnjMzIy9zcANtBxoGoE9u-ettXwG245K6IYx_If6m4D3UI9LgaR8aiG4ECs8Q6xZhJahieBqoa9pFSBdjizjBCgYXuyUN_yB6aGjvOqB3LY4u0mSBe2TLuw5h_33dJbcX5zdnl9n8-s_V2ek8q4VRY1bUhlVclmCUrI0BoyGddJqk5FA6ITUH5hujnRJeyqLwtVGiUj6vitS2FLvkaO27iOFxAhxt32INXecGCBPaXBlViEJLldCfX9CHMMUhdWdzzROUfrxIVL6m6hgQI3i7iG3v4tJyZlfR2HU0NkVj36KxPIkO362nqofmv-QjiwSINYCpNNxD_Hz7G9tXgwqZLA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2618381368</pqid></control><display><type>article</type><title>Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>Almeida, Douglas Lopes ; Moreira, Veridiana Mota ; Cardoso, Lucas Eduardo ; Junior, Marcos Divino Ferreira ; Pavanelo, Audrei ; Ribeiro, Tatiane Aparecida ; da Silva Franco, Claudinéia Conationi ; Tófolo, Laize Perón ; Peres, Maria Natália Chimirri ; Ribeiro, Maiara Vanusa Guedes ; Ferreira, Anna Rebeka Oliveira ; Gomes, Rodrigo Mello ; Miranda, Rosiane Aparecida ; Trevenzoli, Isis Hara ; Armitage, James Andrew ; Palma-Rigo, Kesia ; de Freitas Mathias, Paulo Cesar</creator><creatorcontrib>Almeida, Douglas Lopes ; Moreira, Veridiana Mota ; Cardoso, Lucas Eduardo ; Junior, Marcos Divino Ferreira ; Pavanelo, Audrei ; Ribeiro, Tatiane Aparecida ; da Silva Franco, Claudinéia Conationi ; Tófolo, Laize Perón ; Peres, Maria Natália Chimirri ; Ribeiro, Maiara Vanusa Guedes ; Ferreira, Anna Rebeka Oliveira ; Gomes, Rodrigo Mello ; Miranda, Rosiane Aparecida ; Trevenzoli, Isis Hara ; Armitage, James Andrew ; Palma-Rigo, Kesia ; de Freitas Mathias, Paulo Cesar</creatorcontrib><description><![CDATA[Background
Early postnatal overfeeding (PO) induces long-term overweight and reduces brown adipose tissue (BAT) thermogenesis. Exercise has been suggested as a possible intervention to increase BAT function. In this study, we investigated chronical effects of moderate-intensity exercise in BAT function in postnatal overfed male Wistar rats
Methods
Litters’ delivery was on postnatal-day 0 - PN0. At PN2, litters were adjusted to nine (normal litter – NL) or three pups (small litter – SL) per dam. Animals were weaned on PN21 and in PN30 randomly divided into sedentary (NL-Sed and SL-Sed) or exercised (NL-Exe and SL-Exe), N of 14 litters per group. Exercise protocol started (PN30) with an effort test; training sessions were performed three times weekly at 60% of the VO
2max
achieved in effort test, until PN80. On PN81, a temperature transponder was implanted beneath the interscapular BAT, whose temperature was assessed in periods of lights-on and -off from PN87 to PN90. Sympathetic nerve activation of BAT was registered at PN90. Animals were euthanized at PN91 and tissues collected
Results
PO impaired BAT thermogenesis in lights-on (
p
PO
< 0.0001) and -off (
p
PO
< 0.01). Exercise increased BAT temperature in lights-on (
p
Exe
< 0.0001). In NL-Exe, increased BAT activity was associated with higher sympathetic activity (
p
Exe
< 0.05), β3-AR (
p
Exe
< 0.001), and UCP1 (
p
Exe
< 0.001) content. In SL-Exe, increasing BAT thermogenesis is driven by a combination of tissue morphology remodeling (
p
Exe
< 0.0001) with greater effect in increasing UCP1 (
p
Exe
< 0.001) and increased β3-AR (
p
Exe
< 0.001) content.
Conclusion
Moderate exercise chronically increased BAT thermogenesis in both, NL and SL groups. In NL-Exe by increasing Sympathetic activity, and in SL-Exe by a combination of increased β3-AR and UCP1 content with morphologic remodeling of BAT. Chronically increasing BAT thermogenesis in obese subjects may lead to higher overall energy expenditure, favoring the reduction of obesity and related comorbidities.]]></description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-021-00969-1</identifier><identifier>PMID: 34552207</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14 ; 14/63 ; 631/443 ; 692/499 ; Adipose tissue ; Adipose tissue (brown) ; Adipose Tissue, Brown - metabolism ; Animals ; Body fat ; Body weight ; Brazil ; Disease Models, Animal ; Energy expenditure ; Epidemiology ; Health Promotion and Disease Prevention ; Internal Medicine ; Litter ; Litter size ; Males ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Mice ; Obesity ; Obesity - diagnosis ; Obesity - physiopathology ; Overweight ; Oxygen consumption ; Physical Conditioning, Animal - methods ; Physical Conditioning, Animal - physiology ; Public Health ; Rats ; Rats, Wistar - growth & development ; Rats, Wistar - metabolism ; Rodents ; Sympathetic nerves ; Thermogenesis</subject><ispartof>International Journal of Obesity, 2022-01, Vol.46 (1), p.137-143</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8c70b149e754c77e76e149650291e9a3461e0fd76a53f4488fc753b5f2b8fec43</citedby><cites>FETCH-LOGICAL-c375t-8c70b149e754c77e76e149650291e9a3461e0fd76a53f4488fc753b5f2b8fec43</cites><orcidid>0000-0003-0490-1212 ; 0000-0002-1596-9821 ; 0000-0002-3762-0911 ; 0000-0003-0978-7949</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-021-00969-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-021-00969-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34552207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almeida, Douglas Lopes</creatorcontrib><creatorcontrib>Moreira, Veridiana Mota</creatorcontrib><creatorcontrib>Cardoso, Lucas Eduardo</creatorcontrib><creatorcontrib>Junior, Marcos Divino Ferreira</creatorcontrib><creatorcontrib>Pavanelo, Audrei</creatorcontrib><creatorcontrib>Ribeiro, Tatiane Aparecida</creatorcontrib><creatorcontrib>da Silva Franco, Claudinéia Conationi</creatorcontrib><creatorcontrib>Tófolo, Laize Perón</creatorcontrib><creatorcontrib>Peres, Maria Natália Chimirri</creatorcontrib><creatorcontrib>Ribeiro, Maiara Vanusa Guedes</creatorcontrib><creatorcontrib>Ferreira, Anna Rebeka Oliveira</creatorcontrib><creatorcontrib>Gomes, Rodrigo Mello</creatorcontrib><creatorcontrib>Miranda, Rosiane Aparecida</creatorcontrib><creatorcontrib>Trevenzoli, Isis Hara</creatorcontrib><creatorcontrib>Armitage, James Andrew</creatorcontrib><creatorcontrib>Palma-Rigo, Kesia</creatorcontrib><creatorcontrib>de Freitas Mathias, Paulo Cesar</creatorcontrib><title>Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description><![CDATA[Background
Early postnatal overfeeding (PO) induces long-term overweight and reduces brown adipose tissue (BAT) thermogenesis. Exercise has been suggested as a possible intervention to increase BAT function. In this study, we investigated chronical effects of moderate-intensity exercise in BAT function in postnatal overfed male Wistar rats
Methods
Litters’ delivery was on postnatal-day 0 - PN0. At PN2, litters were adjusted to nine (normal litter – NL) or three pups (small litter – SL) per dam. Animals were weaned on PN21 and in PN30 randomly divided into sedentary (NL-Sed and SL-Sed) or exercised (NL-Exe and SL-Exe), N of 14 litters per group. Exercise protocol started (PN30) with an effort test; training sessions were performed three times weekly at 60% of the VO
2max
achieved in effort test, until PN80. On PN81, a temperature transponder was implanted beneath the interscapular BAT, whose temperature was assessed in periods of lights-on and -off from PN87 to PN90. Sympathetic nerve activation of BAT was registered at PN90. Animals were euthanized at PN91 and tissues collected
Results
PO impaired BAT thermogenesis in lights-on (
p
PO
< 0.0001) and -off (
p
PO
< 0.01). Exercise increased BAT temperature in lights-on (
p
Exe
< 0.0001). In NL-Exe, increased BAT activity was associated with higher sympathetic activity (
p
Exe
< 0.05), β3-AR (
p
Exe
< 0.001), and UCP1 (
p
Exe
< 0.001) content. In SL-Exe, increasing BAT thermogenesis is driven by a combination of tissue morphology remodeling (
p
Exe
< 0.0001) with greater effect in increasing UCP1 (
p
Exe
< 0.001) and increased β3-AR (
p
Exe
< 0.001) content.
Conclusion
Moderate exercise chronically increased BAT thermogenesis in both, NL and SL groups. In NL-Exe by increasing Sympathetic activity, and in SL-Exe by a combination of increased β3-AR and UCP1 content with morphologic remodeling of BAT. Chronically increasing BAT thermogenesis in obese subjects may lead to higher overall energy expenditure, favoring the reduction of obesity and related comorbidities.]]></description><subject>14</subject><subject>14/63</subject><subject>631/443</subject><subject>692/499</subject><subject>Adipose tissue</subject><subject>Adipose tissue (brown)</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Animals</subject><subject>Body fat</subject><subject>Body weight</subject><subject>Brazil</subject><subject>Disease Models, Animal</subject><subject>Energy expenditure</subject><subject>Epidemiology</subject><subject>Health Promotion and Disease Prevention</subject><subject>Internal Medicine</subject><subject>Litter</subject><subject>Litter size</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Obesity</subject><subject>Obesity - diagnosis</subject><subject>Obesity - physiopathology</subject><subject>Overweight</subject><subject>Oxygen consumption</subject><subject>Physical Conditioning, Animal - methods</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Public Health</subject><subject>Rats</subject><subject>Rats, Wistar - growth & development</subject><subject>Rats, Wistar - metabolism</subject><subject>Rodents</subject><subject>Sympathetic nerves</subject><subject>Thermogenesis</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctO5DAQRS0Egh7gB1ggS7NhMQE7fiWzQwgGpJbYgFhaTlJmgpK4cSUDLX4eNw2DxIKVH3XudZUvIQecHXMmihOUXGidsZxnjJW6zPgGmXFpdKZkaTbJjAlmMqa02iE_EB8YY0qxfJvsCKlUnjMzIy9zcANtBxoGoE9u-ettXwG245K6IYx_If6m4D3UI9LgaR8aiG4ECs8Q6xZhJahieBqoa9pFSBdjizjBCgYXuyUN_yB6aGjvOqB3LY4u0mSBe2TLuw5h_33dJbcX5zdnl9n8-s_V2ek8q4VRY1bUhlVclmCUrI0BoyGddJqk5FA6ITUH5hujnRJeyqLwtVGiUj6vitS2FLvkaO27iOFxAhxt32INXecGCBPaXBlViEJLldCfX9CHMMUhdWdzzROUfrxIVL6m6hgQI3i7iG3v4tJyZlfR2HU0NkVj36KxPIkO362nqofmv-QjiwSINYCpNNxD_Hz7G9tXgwqZLA</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Almeida, Douglas Lopes</creator><creator>Moreira, Veridiana Mota</creator><creator>Cardoso, Lucas Eduardo</creator><creator>Junior, Marcos Divino Ferreira</creator><creator>Pavanelo, Audrei</creator><creator>Ribeiro, Tatiane Aparecida</creator><creator>da Silva Franco, Claudinéia Conationi</creator><creator>Tófolo, Laize Perón</creator><creator>Peres, Maria Natália Chimirri</creator><creator>Ribeiro, Maiara Vanusa Guedes</creator><creator>Ferreira, Anna Rebeka Oliveira</creator><creator>Gomes, Rodrigo Mello</creator><creator>Miranda, Rosiane Aparecida</creator><creator>Trevenzoli, Isis Hara</creator><creator>Armitage, James Andrew</creator><creator>Palma-Rigo, Kesia</creator><creator>de Freitas Mathias, Paulo Cesar</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0490-1212</orcidid><orcidid>https://orcid.org/0000-0002-1596-9821</orcidid><orcidid>https://orcid.org/0000-0002-3762-0911</orcidid><orcidid>https://orcid.org/0000-0003-0978-7949</orcidid></search><sort><creationdate>20220101</creationdate><title>Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats</title><author>Almeida, Douglas Lopes ; Moreira, Veridiana Mota ; Cardoso, Lucas Eduardo ; Junior, Marcos Divino Ferreira ; Pavanelo, Audrei ; Ribeiro, Tatiane Aparecida ; da Silva Franco, Claudinéia Conationi ; Tófolo, Laize Perón ; Peres, Maria Natália Chimirri ; Ribeiro, Maiara Vanusa Guedes ; Ferreira, Anna Rebeka Oliveira ; Gomes, Rodrigo Mello ; Miranda, Rosiane Aparecida ; Trevenzoli, Isis Hara ; Armitage, James Andrew ; Palma-Rigo, Kesia ; de Freitas Mathias, Paulo Cesar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8c70b149e754c77e76e149650291e9a3461e0fd76a53f4488fc753b5f2b8fec43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>14</topic><topic>14/63</topic><topic>631/443</topic><topic>692/499</topic><topic>Adipose tissue</topic><topic>Adipose tissue (brown)</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Animals</topic><topic>Body fat</topic><topic>Body weight</topic><topic>Brazil</topic><topic>Disease Models, Animal</topic><topic>Energy expenditure</topic><topic>Epidemiology</topic><topic>Health Promotion and Disease Prevention</topic><topic>Internal Medicine</topic><topic>Litter</topic><topic>Litter size</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Obesity</topic><topic>Obesity - diagnosis</topic><topic>Obesity - physiopathology</topic><topic>Overweight</topic><topic>Oxygen consumption</topic><topic>Physical Conditioning, Animal - methods</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Public Health</topic><topic>Rats</topic><topic>Rats, Wistar - growth & development</topic><topic>Rats, Wistar - metabolism</topic><topic>Rodents</topic><topic>Sympathetic nerves</topic><topic>Thermogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almeida, Douglas Lopes</creatorcontrib><creatorcontrib>Moreira, Veridiana Mota</creatorcontrib><creatorcontrib>Cardoso, Lucas Eduardo</creatorcontrib><creatorcontrib>Junior, Marcos Divino Ferreira</creatorcontrib><creatorcontrib>Pavanelo, Audrei</creatorcontrib><creatorcontrib>Ribeiro, Tatiane Aparecida</creatorcontrib><creatorcontrib>da Silva Franco, Claudinéia Conationi</creatorcontrib><creatorcontrib>Tófolo, Laize Perón</creatorcontrib><creatorcontrib>Peres, Maria Natália Chimirri</creatorcontrib><creatorcontrib>Ribeiro, Maiara Vanusa Guedes</creatorcontrib><creatorcontrib>Ferreira, Anna Rebeka Oliveira</creatorcontrib><creatorcontrib>Gomes, Rodrigo Mello</creatorcontrib><creatorcontrib>Miranda, Rosiane Aparecida</creatorcontrib><creatorcontrib>Trevenzoli, Isis Hara</creatorcontrib><creatorcontrib>Armitage, James Andrew</creatorcontrib><creatorcontrib>Palma-Rigo, Kesia</creatorcontrib><creatorcontrib>de Freitas Mathias, Paulo Cesar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almeida, Douglas Lopes</au><au>Moreira, Veridiana Mota</au><au>Cardoso, Lucas Eduardo</au><au>Junior, Marcos Divino Ferreira</au><au>Pavanelo, Audrei</au><au>Ribeiro, Tatiane Aparecida</au><au>da Silva Franco, Claudinéia Conationi</au><au>Tófolo, Laize Perón</au><au>Peres, Maria Natália Chimirri</au><au>Ribeiro, Maiara Vanusa Guedes</au><au>Ferreira, Anna Rebeka Oliveira</au><au>Gomes, Rodrigo Mello</au><au>Miranda, Rosiane Aparecida</au><au>Trevenzoli, Isis Hara</au><au>Armitage, James Andrew</au><au>Palma-Rigo, Kesia</au><au>de Freitas Mathias, Paulo Cesar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>46</volume><issue>1</issue><spage>137</spage><epage>143</epage><pages>137-143</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract><![CDATA[Background
Early postnatal overfeeding (PO) induces long-term overweight and reduces brown adipose tissue (BAT) thermogenesis. Exercise has been suggested as a possible intervention to increase BAT function. In this study, we investigated chronical effects of moderate-intensity exercise in BAT function in postnatal overfed male Wistar rats
Methods
Litters’ delivery was on postnatal-day 0 - PN0. At PN2, litters were adjusted to nine (normal litter – NL) or three pups (small litter – SL) per dam. Animals were weaned on PN21 and in PN30 randomly divided into sedentary (NL-Sed and SL-Sed) or exercised (NL-Exe and SL-Exe), N of 14 litters per group. Exercise protocol started (PN30) with an effort test; training sessions were performed three times weekly at 60% of the VO
2max
achieved in effort test, until PN80. On PN81, a temperature transponder was implanted beneath the interscapular BAT, whose temperature was assessed in periods of lights-on and -off from PN87 to PN90. Sympathetic nerve activation of BAT was registered at PN90. Animals were euthanized at PN91 and tissues collected
Results
PO impaired BAT thermogenesis in lights-on (
p
PO
< 0.0001) and -off (
p
PO
< 0.01). Exercise increased BAT temperature in lights-on (
p
Exe
< 0.0001). In NL-Exe, increased BAT activity was associated with higher sympathetic activity (
p
Exe
< 0.05), β3-AR (
p
Exe
< 0.001), and UCP1 (
p
Exe
< 0.001) content. In SL-Exe, increasing BAT thermogenesis is driven by a combination of tissue morphology remodeling (
p
Exe
< 0.0001) with greater effect in increasing UCP1 (
p
Exe
< 0.001) and increased β3-AR (
p
Exe
< 0.001) content.
Conclusion
Moderate exercise chronically increased BAT thermogenesis in both, NL and SL groups. In NL-Exe by increasing Sympathetic activity, and in SL-Exe by a combination of increased β3-AR and UCP1 content with morphologic remodeling of BAT. Chronically increasing BAT thermogenesis in obese subjects may lead to higher overall energy expenditure, favoring the reduction of obesity and related comorbidities.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34552207</pmid><doi>10.1038/s41366-021-00969-1</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0490-1212</orcidid><orcidid>https://orcid.org/0000-0002-1596-9821</orcidid><orcidid>https://orcid.org/0000-0002-3762-0911</orcidid><orcidid>https://orcid.org/0000-0003-0978-7949</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2022-01, Vol.46 (1), p.137-143 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2575838645 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | 14 14/63 631/443 692/499 Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Animals Body fat Body weight Brazil Disease Models, Animal Energy expenditure Epidemiology Health Promotion and Disease Prevention Internal Medicine Litter Litter size Males Medicine Medicine & Public Health Metabolic Diseases Mice Obesity Obesity - diagnosis Obesity - physiopathology Overweight Oxygen consumption Physical Conditioning, Animal - methods Physical Conditioning, Animal - physiology Public Health Rats Rats, Wistar - growth & development Rats, Wistar - metabolism Rodents Sympathetic nerves Thermogenesis |
| title | Lean in one way, in obesity another: effects of moderate exercise in brown adipose tissue of early overfed male Wistar rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T22%3A20%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lean%20in%20one%20way,%20in%20obesity%20another:%20effects%20of%20moderate%20exercise%20in%20brown%20adipose%20tissue%20of%20early%20overfed%20male%20Wistar%20rats&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Almeida,%20Douglas%20Lopes&rft.date=2022-01-01&rft.volume=46&rft.issue=1&rft.spage=137&rft.epage=143&rft.pages=137-143&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/s41366-021-00969-1&rft_dat=%3Cproquest_cross%3E2618381368%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2618381368&rft_id=info:pmid/34552207&rfr_iscdi=true |