Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile
Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in the intestine also promote the growth of other prominent bacteria. Therefore, the growth-promoting effects of β-galactosides on intestinal bacteria were analyzed. Galactosyl-β1,4-l-rhamnose (Gal-β1,4-Rha) selectivel...
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| Veröffentlicht in: | Gut microbes 2021-01, Vol.13 (1), p.1973835-1973835 |
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| creator | Hirano, Rika Sakanaka, Mikiyasu Yoshimi, Kazuto Sugimoto, Naohisa Eguchi, Syogo Yamauchi, Yuko Nara, Misaki Maeda, Shingo Ami, Yuta Gotoh, Aina Katayama, Takane Iida, Noriho Kato, Tamotsu Ohno, Hiroshi Fukiya, Satoru Yokota, Atsushi Nishimoto, Mamoru Kitaoka, Motomitsu Nakai, Hiroyuki Kurihara, Shin |
| description | Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in the intestine also promote the growth of other prominent bacteria. Therefore, the growth-promoting effects of β-galactosides on intestinal bacteria were analyzed. Galactosyl-β1,4-l-rhamnose (Gal-β1,4-Rha) selectively promoted the growth of Bifidobacterium. Bifidobacterium longum subsp. longum 105-A (JCM 31944) has multiple solute-binding proteins belonging to ATP-binding cassette transporters for sugars. Each strain in the library of 11 B. longum subsp. longum mutants, in which each gene of the solute-binding protein was disrupted, was cultured in a medium containing Gal-β1,4-Rha as the sole carbon source, and only the BL105A_0502 gene-disruption mutant showed delayed and reduced growth compared to the wild-type strain. BL105A_0502 homolog is highly conserved in bifidobacteria. In a Gal-β1,4-Rha-containing medium, Bifidobacterium longum subsp. infantis JCM 1222
T
, which possesses BLIJ_2090, a homologous protein to BL105A_0502, suppressed the growth of enteric pathogen Clostridioides difficile, whereas the BLIJ_2090 gene-disrupted mutant did not. In vivo, administration of B. infantis and Gal-β1,4-Rha alleviated C. difficile infection-related weight loss in mice. We have successfully screened Gal-β1,4-Rha as a next-generation prebiotic candidate that specifically promotes the growth of beneficial bacteria without promoting the growth of prominent bacteria and pathogens. |
| doi_str_mv | 10.1080/19490976.2021.1973835 |
| format | Article |
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T
, which possesses BLIJ_2090, a homologous protein to BL105A_0502, suppressed the growth of enteric pathogen Clostridioides difficile, whereas the BLIJ_2090 gene-disrupted mutant did not. In vivo, administration of B. infantis and Gal-β1,4-Rha alleviated C. difficile infection-related weight loss in mice. We have successfully screened Gal-β1,4-Rha as a next-generation prebiotic candidate that specifically promotes the growth of beneficial bacteria without promoting the growth of prominent bacteria and pathogens.</description><identifier>ISSN: 1949-0976</identifier><identifier>EISSN: 1949-0984</identifier><identifier>DOI: 10.1080/19490976.2021.1973835</identifier><identifier>PMID: 34553672</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; ATP-Binding Cassette Transporters - metabolism ; bifidobacteria ; Bifidobacterium - genetics ; Bifidobacterium - growth & development ; Bifidobacterium longum subspecies infantis - genetics ; Bifidobacterium longum subspecies infantis - growth & development ; Clostridioides difficile ; Clostridioides difficile - growth & development ; Disaccharides - pharmacology ; Gastrointestinal Microbiome - drug effects ; Humans ; Intestines - microbiology ; Male ; Mice ; Mice, Inbred C57BL ; microbiome ; microbiota ; Prebiotic ; Prebiotics - analysis ; probiotic ; Research Paper</subject><ispartof>Gut microbes, 2021-01, Vol.13 (1), p.1973835-1973835</ispartof><rights>2021 The Author(s). Published with license by Taylor & Francis Group, LLC. 2021</rights><rights>2021 The Author(s). Published with license by Taylor & Francis Group, LLC. 2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c600t-1be99b9cce6a7fdaf46f015c2196bbd0b2ef5563b7f5bad69907ce246d3b2dd03</citedby><cites>FETCH-LOGICAL-c600t-1be99b9cce6a7fdaf46f015c2196bbd0b2ef5563b7f5bad69907ce246d3b2dd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475593/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475593/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,27481,27903,27904,53769,53771,59119,59120</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34553672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirano, Rika</creatorcontrib><creatorcontrib>Sakanaka, Mikiyasu</creatorcontrib><creatorcontrib>Yoshimi, Kazuto</creatorcontrib><creatorcontrib>Sugimoto, Naohisa</creatorcontrib><creatorcontrib>Eguchi, Syogo</creatorcontrib><creatorcontrib>Yamauchi, Yuko</creatorcontrib><creatorcontrib>Nara, Misaki</creatorcontrib><creatorcontrib>Maeda, Shingo</creatorcontrib><creatorcontrib>Ami, Yuta</creatorcontrib><creatorcontrib>Gotoh, Aina</creatorcontrib><creatorcontrib>Katayama, Takane</creatorcontrib><creatorcontrib>Iida, Noriho</creatorcontrib><creatorcontrib>Kato, Tamotsu</creatorcontrib><creatorcontrib>Ohno, Hiroshi</creatorcontrib><creatorcontrib>Fukiya, Satoru</creatorcontrib><creatorcontrib>Yokota, Atsushi</creatorcontrib><creatorcontrib>Nishimoto, Mamoru</creatorcontrib><creatorcontrib>Kitaoka, Motomitsu</creatorcontrib><creatorcontrib>Nakai, Hiroyuki</creatorcontrib><creatorcontrib>Kurihara, Shin</creatorcontrib><title>Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile</title><title>Gut microbes</title><addtitle>Gut Microbes</addtitle><description>Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in the intestine also promote the growth of other prominent bacteria. Therefore, the growth-promoting effects of β-galactosides on intestinal bacteria were analyzed. Galactosyl-β1,4-l-rhamnose (Gal-β1,4-Rha) selectively promoted the growth of Bifidobacterium. Bifidobacterium longum subsp. longum 105-A (JCM 31944) has multiple solute-binding proteins belonging to ATP-binding cassette transporters for sugars. Each strain in the library of 11 B. longum subsp. longum mutants, in which each gene of the solute-binding protein was disrupted, was cultured in a medium containing Gal-β1,4-Rha as the sole carbon source, and only the BL105A_0502 gene-disruption mutant showed delayed and reduced growth compared to the wild-type strain. BL105A_0502 homolog is highly conserved in bifidobacteria. In a Gal-β1,4-Rha-containing medium, Bifidobacterium longum subsp. infantis JCM 1222
T
, which possesses BLIJ_2090, a homologous protein to BL105A_0502, suppressed the growth of enteric pathogen Clostridioides difficile, whereas the BLIJ_2090 gene-disrupted mutant did not. In vivo, administration of B. infantis and Gal-β1,4-Rha alleviated C. difficile infection-related weight loss in mice. We have successfully screened Gal-β1,4-Rha as a next-generation prebiotic candidate that specifically promotes the growth of beneficial bacteria without promoting the growth of prominent bacteria and pathogens.</description><subject>Animals</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>bifidobacteria</subject><subject>Bifidobacterium - genetics</subject><subject>Bifidobacterium - growth & development</subject><subject>Bifidobacterium longum subspecies infantis - genetics</subject><subject>Bifidobacterium longum subspecies infantis - growth & development</subject><subject>Clostridioides difficile</subject><subject>Clostridioides difficile - growth & development</subject><subject>Disaccharides - pharmacology</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Humans</subject><subject>Intestines - microbiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>microbiome</subject><subject>microbiota</subject><subject>Prebiotic</subject><subject>Prebiotics - analysis</subject><subject>probiotic</subject><subject>Research Paper</subject><issn>1949-0976</issn><issn>1949-0984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kV9vFCEUxSdGY5vaj6CZRx-clYEBhhej2WjbpNEXfSb8uUypzLAC29pvL-tuN_ZFXri5nPO7wGma1z1a9WhE73sxCCQ4W2GE-1UvOBkJfdac7vodEuPw_FhzdtKc53yL6hoGjhh52ZyQgVLCOD5tfn6F36WbYIGkio9Lu0mgfSze1CrOsUBuMwQwxd9BO6V4X27a6FrtnbdRK1MgefWuzdtNdebsl6ldh5hL8tZHb6vdeue88QFeNS-cChnOD_tZ8-PL5-_ry-7628XV-tN1ZxhCpes1CKGFMcAUd1a5gTnUU4N7wbS2SGNwlDKiuaNaWSYE4gbwwCzR2FpEzpqrPddGdSs3yc8qPciovPzbiGmSKtUXBpCjHbEwjFBcP21kRDjDuMWgRkssQaayPuxZm62ewRpYSlLhCfTpyeJv5BTv5DhwSgWpgLcHQIq_tpCLnH02EIJaIG6zxJTTkTCKWZXSvdSkmHMCdxzTI7nLXT7mLne5y0Pu1ffm3zseXY8pV8HHvcAvLqZZ3ccUrCzqIcTkklqMz5L8f8Yf837AzQ</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Hirano, Rika</creator><creator>Sakanaka, Mikiyasu</creator><creator>Yoshimi, Kazuto</creator><creator>Sugimoto, Naohisa</creator><creator>Eguchi, Syogo</creator><creator>Yamauchi, Yuko</creator><creator>Nara, Misaki</creator><creator>Maeda, Shingo</creator><creator>Ami, Yuta</creator><creator>Gotoh, Aina</creator><creator>Katayama, Takane</creator><creator>Iida, Noriho</creator><creator>Kato, Tamotsu</creator><creator>Ohno, Hiroshi</creator><creator>Fukiya, Satoru</creator><creator>Yokota, Atsushi</creator><creator>Nishimoto, Mamoru</creator><creator>Kitaoka, Motomitsu</creator><creator>Nakai, Hiroyuki</creator><creator>Kurihara, Shin</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210101</creationdate><title>Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile</title><author>Hirano, Rika ; Sakanaka, Mikiyasu ; Yoshimi, Kazuto ; Sugimoto, Naohisa ; Eguchi, Syogo ; Yamauchi, Yuko ; Nara, Misaki ; Maeda, Shingo ; Ami, Yuta ; Gotoh, Aina ; Katayama, Takane ; Iida, Noriho ; Kato, Tamotsu ; Ohno, Hiroshi ; Fukiya, Satoru ; Yokota, Atsushi ; Nishimoto, Mamoru ; Kitaoka, Motomitsu ; Nakai, Hiroyuki ; Kurihara, Shin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c600t-1be99b9cce6a7fdaf46f015c2196bbd0b2ef5563b7f5bad69907ce246d3b2dd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>bifidobacteria</topic><topic>Bifidobacterium - genetics</topic><topic>Bifidobacterium - growth & development</topic><topic>Bifidobacterium longum subspecies infantis - genetics</topic><topic>Bifidobacterium longum subspecies infantis - growth & development</topic><topic>Clostridioides difficile</topic><topic>Clostridioides difficile - growth & development</topic><topic>Disaccharides - pharmacology</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Humans</topic><topic>Intestines - microbiology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>microbiome</topic><topic>microbiota</topic><topic>Prebiotic</topic><topic>Prebiotics - analysis</topic><topic>probiotic</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirano, Rika</creatorcontrib><creatorcontrib>Sakanaka, Mikiyasu</creatorcontrib><creatorcontrib>Yoshimi, Kazuto</creatorcontrib><creatorcontrib>Sugimoto, Naohisa</creatorcontrib><creatorcontrib>Eguchi, Syogo</creatorcontrib><creatorcontrib>Yamauchi, Yuko</creatorcontrib><creatorcontrib>Nara, Misaki</creatorcontrib><creatorcontrib>Maeda, Shingo</creatorcontrib><creatorcontrib>Ami, Yuta</creatorcontrib><creatorcontrib>Gotoh, Aina</creatorcontrib><creatorcontrib>Katayama, Takane</creatorcontrib><creatorcontrib>Iida, Noriho</creatorcontrib><creatorcontrib>Kato, Tamotsu</creatorcontrib><creatorcontrib>Ohno, Hiroshi</creatorcontrib><creatorcontrib>Fukiya, Satoru</creatorcontrib><creatorcontrib>Yokota, Atsushi</creatorcontrib><creatorcontrib>Nishimoto, Mamoru</creatorcontrib><creatorcontrib>Kitaoka, Motomitsu</creatorcontrib><creatorcontrib>Nakai, Hiroyuki</creatorcontrib><creatorcontrib>Kurihara, Shin</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gut microbes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirano, Rika</au><au>Sakanaka, Mikiyasu</au><au>Yoshimi, Kazuto</au><au>Sugimoto, Naohisa</au><au>Eguchi, Syogo</au><au>Yamauchi, Yuko</au><au>Nara, Misaki</au><au>Maeda, Shingo</au><au>Ami, Yuta</au><au>Gotoh, Aina</au><au>Katayama, Takane</au><au>Iida, Noriho</au><au>Kato, Tamotsu</au><au>Ohno, Hiroshi</au><au>Fukiya, Satoru</au><au>Yokota, Atsushi</au><au>Nishimoto, Mamoru</au><au>Kitaoka, Motomitsu</au><au>Nakai, Hiroyuki</au><au>Kurihara, Shin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile</atitle><jtitle>Gut microbes</jtitle><addtitle>Gut Microbes</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>13</volume><issue>1</issue><spage>1973835</spage><epage>1973835</epage><pages>1973835-1973835</pages><issn>1949-0976</issn><eissn>1949-0984</eissn><abstract>Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in the intestine also promote the growth of other prominent bacteria. Therefore, the growth-promoting effects of β-galactosides on intestinal bacteria were analyzed. Galactosyl-β1,4-l-rhamnose (Gal-β1,4-Rha) selectively promoted the growth of Bifidobacterium. Bifidobacterium longum subsp. longum 105-A (JCM 31944) has multiple solute-binding proteins belonging to ATP-binding cassette transporters for sugars. Each strain in the library of 11 B. longum subsp. longum mutants, in which each gene of the solute-binding protein was disrupted, was cultured in a medium containing Gal-β1,4-Rha as the sole carbon source, and only the BL105A_0502 gene-disruption mutant showed delayed and reduced growth compared to the wild-type strain. BL105A_0502 homolog is highly conserved in bifidobacteria. In a Gal-β1,4-Rha-containing medium, Bifidobacterium longum subsp. infantis JCM 1222
T
, which possesses BLIJ_2090, a homologous protein to BL105A_0502, suppressed the growth of enteric pathogen Clostridioides difficile, whereas the BLIJ_2090 gene-disrupted mutant did not. In vivo, administration of B. infantis and Gal-β1,4-Rha alleviated C. difficile infection-related weight loss in mice. We have successfully screened Gal-β1,4-Rha as a next-generation prebiotic candidate that specifically promotes the growth of beneficial bacteria without promoting the growth of prominent bacteria and pathogens.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>34553672</pmid><doi>10.1080/19490976.2021.1973835</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals ATP-Binding Cassette Transporters - metabolism bifidobacteria Bifidobacterium - genetics Bifidobacterium - growth & development Bifidobacterium longum subspecies infantis - genetics Bifidobacterium longum subspecies infantis - growth & development Clostridioides difficile Clostridioides difficile - growth & development Disaccharides - pharmacology Gastrointestinal Microbiome - drug effects Humans Intestines - microbiology Male Mice Mice, Inbred C57BL microbiome microbiota Prebiotic Prebiotics - analysis probiotic Research Paper |
| title | Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile |
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