SMAR1 suppresses the cancer stem cell population via hTERT repression in colorectal cancer cells

One of the hallmarks of a cancer cell is the ability for indefinite proliferation leading to the immortalization of the cell. Activation of several signaling pathways leads to the immortalization of cancer cells via the reactivation of enzyme telomerase (hTERT). hTERT is active in germ cells, stem c...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2021-12, Vol.141, p.106085, Article 106085
Hauptverfasser:	Parulekar, Apoorva, Choksi, Arpankumar, Taye, Nandaraj, Totakura, Kumar V.S., Firmal, Priyanka, Kundu, Gopal C., Chattopadhyay, Samit
Format:	Artikel
Sprache:	eng
Schlagworte:	CD133 CD44 Cell Cycle Proteins Cell Line, Tumor Cell Proliferation Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology CSC DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Neoplastic HDAC1 Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism hTERT promoter Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Promoter Regions, Genetic - genetics Repressor Proteins - genetics Repressor Proteins - metabolism SMAR1 Telomerase - genetics Telomerase - metabolism
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