Challenging anticoagulation cases: A case of heparin-induced-thrombocytopenia in the first trimester of pregnancy
Heparin-induced thrombocytopenia in pregnancy is an uncommon phenomenon which rarely occurs in the first trimester. Therapeutic options and duration of therapeutic anticoagulation are varied amongst reported published cases. We report a 41-year-old female with confirmed HIT following anticoagulation...
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| Veröffentlicht in: | Thrombosis research 2021-11, Vol.207, p.58-61 |
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| creator | Lovatt, Catherine Anne Crowther, Mark A. |
| description | Heparin-induced thrombocytopenia in pregnancy is an uncommon phenomenon which rarely occurs in the first trimester. Therapeutic options and duration of therapeutic anticoagulation are varied amongst reported published cases. We report a 41-year-old female with confirmed HIT following anticoagulation with dalteparin for deep vein thrombosis (DVT). She was treated with therapeutic fondaparinux for 3 months followed by prophylaxis dosage until delivery and for 6 weeks thereafter. A review of reported cases of the development of HIT in the first trimester and subsequent clinical management is discussed.
•Heparin-induced thrombocytopenia (HIT) in pregnancy, especially in the first trimester, is uncommon•Fondaparinux is a reasonable anticoagulation option for HIT in pregnancy•Duration of therapeutic anticoagulation for provoked emboli in pregnancy is unclear•Involvement of a tertiary center for anticoagulation and obstetrical management for pregnant patients with HIT is recommended |
| doi_str_mv | 10.1016/j.thromres.2021.09.001 |
| format | Article |
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•Heparin-induced thrombocytopenia (HIT) in pregnancy, especially in the first trimester, is uncommon•Fondaparinux is a reasonable anticoagulation option for HIT in pregnancy•Duration of therapeutic anticoagulation for provoked emboli in pregnancy is unclear•Involvement of a tertiary center for anticoagulation and obstetrical management for pregnant patients with HIT is recommended</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2021.09.001</identifier><identifier>PMID: 34547613</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Anticoagulation ; First trimester ; Fondaparinux ; Heparin-induced thrombocytopenia (HIT) ; Pregnancy</subject><ispartof>Thrombosis research, 2021-11, Vol.207, p.58-61</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-bdfc0499661369bccc5ada66661bf90719f7802c9eec10efdc02cc3292d4c9a33</citedby><cites>FETCH-LOGICAL-c368t-bdfc0499661369bccc5ada66661bf90719f7802c9eec10efdc02cc3292d4c9a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0049384821004461$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34547613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lovatt, Catherine Anne</creatorcontrib><creatorcontrib>Crowther, Mark A.</creatorcontrib><title>Challenging anticoagulation cases: A case of heparin-induced-thrombocytopenia in the first trimester of pregnancy</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Heparin-induced thrombocytopenia in pregnancy is an uncommon phenomenon which rarely occurs in the first trimester. Therapeutic options and duration of therapeutic anticoagulation are varied amongst reported published cases. We report a 41-year-old female with confirmed HIT following anticoagulation with dalteparin for deep vein thrombosis (DVT). She was treated with therapeutic fondaparinux for 3 months followed by prophylaxis dosage until delivery and for 6 weeks thereafter. A review of reported cases of the development of HIT in the first trimester and subsequent clinical management is discussed.
•Heparin-induced thrombocytopenia (HIT) in pregnancy, especially in the first trimester, is uncommon•Fondaparinux is a reasonable anticoagulation option for HIT in pregnancy•Duration of therapeutic anticoagulation for provoked emboli in pregnancy is unclear•Involvement of a tertiary center for anticoagulation and obstetrical management for pregnant patients with HIT is recommended</description><subject>Anticoagulation</subject><subject>First trimester</subject><subject>Fondaparinux</subject><subject>Heparin-induced thrombocytopenia (HIT)</subject><subject>Pregnancy</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkMtu2zAQRYmgQew8fsHgshuppB6U2FUNI20DBOimWRPUaGTTkEmZpAr470PHSbfhZjjAvTN3DiErznLOuPi2z-POu4PHkBes4DmTOWP8iix528isqJriC1kyVsmsbKt2QW5D2CdBw2V9QxZlVVeN4OWSHDc7PY5ot8ZuqbbRgNPbedTROEtBBwzf6frtQ91Adzhpb2xmbD8D9tlbhs7BKboJrdHUWBp3SAfjQ6TRmwOGiP5snTxurbZwuifXgx4DPrzXO_Ly8_Hv5nf2_OfX02b9nEEp2ph1_QApvhQpppAdANS61yI93g2SpUOGpmUFSETgDIceUgNlIYu-AqnL8o58vcydvDvOKYc6mAA4jtqim4Mq6qYuG1kLkaTiIgXvQvA4qClF1_6kOFNn3GqvPnCrM27FpEo0k3H1vmPuDtj_t33wTYIfFwGmS_8Z9CqAQZvYGY8QVe_MZzteARrGl50</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Lovatt, Catherine Anne</creator><creator>Crowther, Mark A.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Challenging anticoagulation cases: A case of heparin-induced-thrombocytopenia in the first trimester of pregnancy</title><author>Lovatt, Catherine Anne ; Crowther, Mark A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-bdfc0499661369bccc5ada66661bf90719f7802c9eec10efdc02cc3292d4c9a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticoagulation</topic><topic>First trimester</topic><topic>Fondaparinux</topic><topic>Heparin-induced thrombocytopenia (HIT)</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lovatt, Catherine Anne</creatorcontrib><creatorcontrib>Crowther, Mark A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lovatt, Catherine Anne</au><au>Crowther, Mark A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Challenging anticoagulation cases: A case of heparin-induced-thrombocytopenia in the first trimester of pregnancy</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2021-11</date><risdate>2021</risdate><volume>207</volume><spage>58</spage><epage>61</epage><pages>58-61</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><abstract>Heparin-induced thrombocytopenia in pregnancy is an uncommon phenomenon which rarely occurs in the first trimester. Therapeutic options and duration of therapeutic anticoagulation are varied amongst reported published cases. We report a 41-year-old female with confirmed HIT following anticoagulation with dalteparin for deep vein thrombosis (DVT). She was treated with therapeutic fondaparinux for 3 months followed by prophylaxis dosage until delivery and for 6 weeks thereafter. A review of reported cases of the development of HIT in the first trimester and subsequent clinical management is discussed.
•Heparin-induced thrombocytopenia (HIT) in pregnancy, especially in the first trimester, is uncommon•Fondaparinux is a reasonable anticoagulation option for HIT in pregnancy•Duration of therapeutic anticoagulation for provoked emboli in pregnancy is unclear•Involvement of a tertiary center for anticoagulation and obstetrical management for pregnant patients with HIT is recommended</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>34547613</pmid><doi>10.1016/j.thromres.2021.09.001</doi><tpages>4</tpages></addata></record> |
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| subjects | Anticoagulation First trimester Fondaparinux Heparin-induced thrombocytopenia (HIT) Pregnancy |
| title | Challenging anticoagulation cases: A case of heparin-induced-thrombocytopenia in the first trimester of pregnancy |
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