Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy
Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study,...
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| Veröffentlicht in: | Drug delivery 2021-01, Vol.28 (1), p.1923-1931 |
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| creator | Chen, Gang Ullah, Aftab Xu, Gang Xu, Zhou Wang, Fei Liu, Tianqing Su, Yi Zhang, Tangjie Wang, Kaikai |
| description | Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). The formulation effectively delivered IR780 to subcutaneous tumor and deep metastatic sites, while the hydrogels were applied on the skin overlying the tumor or on an area of distant normal skin. The photothermal antitumor activity of topically administered IR780/lipo/gels was evaluated following laser irradiation. We observed significant inhibition of the rate of the tumor growth without any toxicity associated with the topical administration of hydrogels. Collectively, the topical administration of IR780/lipo/gels represents a new noninvasive and safe strategy for targeted tumor PTT. |
| doi_str_mv | 10.1080/10717544.2021.1974607 |
| format | Article |
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However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). The formulation effectively delivered IR780 to subcutaneous tumor and deep metastatic sites, while the hydrogels were applied on the skin overlying the tumor or on an area of distant normal skin. The photothermal antitumor activity of topically administered IR780/lipo/gels was evaluated following laser irradiation. We observed significant inhibition of the rate of the tumor growth without any toxicity associated with the topical administration of hydrogels. Collectively, the topical administration of IR780/lipo/gels represents a new noninvasive and safe strategy for targeted tumor PTT.</description><identifier>ISSN: 1071-7544</identifier><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.1080/10717544.2021.1974607</identifier><identifier>PMID: 34550040</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Administration, Cutaneous ; Animals ; Body Weight ; Cancer therapies ; Chemistry, Pharmaceutical ; Cholesterol ; Drug Carriers - chemistry ; Drug delivery systems ; Drugs ; Hospitals ; Hydrogels ; Hydrogels - chemistry ; Indoles - administration & dosage ; Indoles - adverse effects ; Indoles - pharmacokinetics ; Indoles - pharmacology ; Infectious diseases ; IR780 ; Laboratories ; liposome-in-hydrogels ; Liposomes - chemistry ; Low-Level Light Therapy - adverse effects ; Low-Level Light Therapy - methods ; Lung Neoplasms - drug therapy ; Lung Neoplasms - secondary ; Male ; Mice ; Mice, Inbred BALB C ; Nanoparticles ; Patient compliance ; Pharmacy ; Photosensitizing Agents - administration & dosage ; Photosensitizing Agents - adverse effects ; Photosensitizing Agents - pharmacokinetics ; Photosensitizing Agents - pharmacology ; photothermal therapy ; Photothermal Therapy - methods ; Product safety ; topical application ; Topical medication ; transdermal drug delivery ; Transdermal medication ; Tumor Burden - drug effects ; Tumors ; Veterinary colleges ; Veterinary medicine ; Xenograft Model Antitumor Assays ; Zoonoses</subject><ispartof>Drug delivery, 2021-01, Vol.28 (1), p.1923-1931</ispartof><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021</rights><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-364749d90ee0932da5e9d19874b3f60de001b70485b7c2a158f7b018e591ea3b3</citedby><cites>FETCH-LOGICAL-c562t-364749d90ee0932da5e9d19874b3f60de001b70485b7c2a158f7b018e591ea3b3</cites><orcidid>0000-0002-1838-4394</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462874/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462874/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27502,27924,27925,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34550040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>Ullah, Aftab</creatorcontrib><creatorcontrib>Xu, Gang</creatorcontrib><creatorcontrib>Xu, Zhou</creatorcontrib><creatorcontrib>Wang, Fei</creatorcontrib><creatorcontrib>Liu, Tianqing</creatorcontrib><creatorcontrib>Su, Yi</creatorcontrib><creatorcontrib>Zhang, Tangjie</creatorcontrib><creatorcontrib>Wang, Kaikai</creatorcontrib><title>Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). The formulation effectively delivered IR780 to subcutaneous tumor and deep metastatic sites, while the hydrogels were applied on the skin overlying the tumor or on an area of distant normal skin. The photothermal antitumor activity of topically administered IR780/lipo/gels was evaluated following laser irradiation. We observed significant inhibition of the rate of the tumor growth without any toxicity associated with the topical administration of hydrogels. Collectively, the topical administration of IR780/lipo/gels represents a new noninvasive and safe strategy for targeted tumor PTT.</description><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Cancer therapies</subject><subject>Chemistry, Pharmaceutical</subject><subject>Cholesterol</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Hospitals</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Indoles - administration & dosage</subject><subject>Indoles - adverse effects</subject><subject>Indoles - pharmacokinetics</subject><subject>Indoles - pharmacology</subject><subject>Infectious diseases</subject><subject>IR780</subject><subject>Laboratories</subject><subject>liposome-in-hydrogels</subject><subject>Liposomes - chemistry</subject><subject>Low-Level Light Therapy - adverse effects</subject><subject>Low-Level Light Therapy - 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However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). The formulation effectively delivered IR780 to subcutaneous tumor and deep metastatic sites, while the hydrogels were applied on the skin overlying the tumor or on an area of distant normal skin. The photothermal antitumor activity of topically administered IR780/lipo/gels was evaluated following laser irradiation. We observed significant inhibition of the rate of the tumor growth without any toxicity associated with the topical administration of hydrogels. Collectively, the topical administration of IR780/lipo/gels represents a new noninvasive and safe strategy for targeted tumor PTT.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>34550040</pmid><doi>10.1080/10717544.2021.1974607</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1838-4394</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Cutaneous Animals Body Weight Cancer therapies Chemistry, Pharmaceutical Cholesterol Drug Carriers - chemistry Drug delivery systems Drugs Hospitals Hydrogels Hydrogels - chemistry Indoles - administration & dosage Indoles - adverse effects Indoles - pharmacokinetics Indoles - pharmacology Infectious diseases IR780 Laboratories liposome-in-hydrogels Liposomes - chemistry Low-Level Light Therapy - adverse effects Low-Level Light Therapy - methods Lung Neoplasms - drug therapy Lung Neoplasms - secondary Male Mice Mice, Inbred BALB C Nanoparticles Patient compliance Pharmacy Photosensitizing Agents - administration & dosage Photosensitizing Agents - adverse effects Photosensitizing Agents - pharmacokinetics Photosensitizing Agents - pharmacology photothermal therapy Photothermal Therapy - methods Product safety topical application Topical medication transdermal drug delivery Transdermal medication Tumor Burden - drug effects Tumors Veterinary colleges Veterinary medicine Xenograft Model Antitumor Assays Zoonoses |
| title | Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy |
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