Nectin cell adhesion molecule-4 (NECTIN-4): A potential target for cancer therapy

NECTIN-4 [a poliovirus receptor-related-4 (pvrl-4) encoded protein] is a Ca2+ independent immunoglobulin-like protein. Along with other Nectins (Nectin-1, -2 and -3), it is primarily involved in cell-cell adhesion. In contrast to other Nectins, Nectin-4 is specifically enriched in the embryonic and...

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Veröffentlicht in:	European journal of pharmacology 2021-11, Vol.911, p.174516, Article 174516
Hauptverfasser:	Chatterjee, Subhajit, Sinha, Saptarshi, Kundu, Chanakya Nath
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cancer Cancer stemness Cell Adhesion Molecules - metabolism Humans Metastasis Molecular Targeted Therapy Nectin-4 Nectins Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Therapeutic strategies
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