Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men
The aim of this study was to assess the influence of physical activity in inflammatory, biochemical and endocrine parameters of middle-aged and elderly men with Systemic Arterial Hypertension (SAH) and Type 2 Diabetes Mellitus (T2DM). The assessment was comprised by 77 male volunteers aged between 4...
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| Veröffentlicht in: | Experimental gerontology 2021-11, Vol.155, p.111558-111558, Article 111558 |
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| creator | Ribeiro, Israel S. Pereira, Ítalo S. Galantini, Maria P.L. Santos, Denisar P. Teles, Mauro F. Muniz, Igor P.R. Santos, Gilvanéia S. Silva, Robson A.A. |
| description | The aim of this study was to assess the influence of physical activity in inflammatory, biochemical and endocrine parameters of middle-aged and elderly men with Systemic Arterial Hypertension (SAH) and Type 2 Diabetes Mellitus (T2DM). The assessment was comprised by 77 male volunteers aged between 45 and 59 years old (middle-aged men) or 60 to 86 years old (elderly men), diagnosed with SAH and T2DM, assisted by Family Health Units in Vitória da Conquista, Bahia, Brazil. According to age and lifestyle (sedentary or practicing physical activity), these men were classified as middle-aged sedentary men, middle-aged physically active men, elderly sedentary men, or elderly physically active men. It was noticed that active elderly people with SAH and T2DM had a better inflammatory balance than sedentary middle-aged men, through the evaluation of the relationship between the cytokines IL-10/TNF-α, IL-10/IL-17A and IL-10/IFN-γ. Moreover, in the extended correlation analysis, a greater global balance was observed among anthropometric, blood pressure, biochemical and cytokine parameters. Physical activity beneficially modulates aging-related disease risk factors even in elderly individuals.
•The benefits of physical activity counterbalance aging harms' in T2DM and SAH men•Active elderly men have better inflammatory balance than sedentary middle-aged men.•IL-10 negatively modulates IL-17A, IFN-γ, IL-1β, and also reduces inflammaging. |
| doi_str_mv | 10.1016/j.exger.2021.111558 |
| format | Article |
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•The benefits of physical activity counterbalance aging harms' in T2DM and SAH men•Active elderly men have better inflammatory balance than sedentary middle-aged men.•IL-10 negatively modulates IL-17A, IFN-γ, IL-1β, and also reduces inflammaging.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Cytokines</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Exercise</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Inflammation - prevention & control</subject><subject>Life Style</subject><subject>Male</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Physical activity</subject><subject>Systemic arterial hypertension</subject><subject>Type 2 diabetes mellitus</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMoWqu_QJAs3UzNYzKZWbgQ8QWCILo1pMlNmzKPmswU59-bWnXp6t4D59zD_RA6o2RGCS0uVzP4XECYMcLojFIqRLmHJrSUPCtKKvbRhAhOMyEKcYSOY1wRQgrG6SE64rnIZU7EBL2_wGKodcDr5Ri90TXWpvcb3484gB0MRNwvAYNzYPqIO4d962rdNHrh20US2Ho9h94brFuLl-MaQg9t9BvADbQn6MDpOsLpz5yit7vb15uH7On5_vHm-ikzXFR9RnPmqGDCGJZzzoyUpciZLK2tGKkk2DkzlZ6TsrBGUpAsCWEdSxurqDN8ii52d9eh-xgg9qrx0UBd6xa6ISompOCSJFTJyndWE7oYAzi1Dr7RYVSUqC1YtVLfYNUWrNqBTanzn4Jh3oD9y_ySTIarnQHSmxuf4tF4aA1YHxI6ZTv_b8EXQ3aK-A</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Ribeiro, Israel S.</creator><creator>Pereira, Ítalo S.</creator><creator>Galantini, Maria P.L.</creator><creator>Santos, Denisar P.</creator><creator>Teles, Mauro F.</creator><creator>Muniz, Igor P.R.</creator><creator>Santos, Gilvanéia S.</creator><creator>Silva, Robson A.A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men</title><author>Ribeiro, Israel S. ; Pereira, Ítalo S. ; Galantini, Maria P.L. ; Santos, Denisar P. ; Teles, Mauro F. ; Muniz, Igor P.R. ; Santos, Gilvanéia S. ; Silva, Robson A.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-142f1525cc24332c77854278dd92097edb2c9ab086dc71e729ab5df2e72291fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Cytokines</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Exercise</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Inflammation - prevention & control</topic><topic>Life Style</topic><topic>Male</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Physical activity</topic><topic>Systemic arterial hypertension</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro, Israel S.</creatorcontrib><creatorcontrib>Pereira, Ítalo S.</creatorcontrib><creatorcontrib>Galantini, Maria P.L.</creatorcontrib><creatorcontrib>Santos, Denisar P.</creatorcontrib><creatorcontrib>Teles, Mauro F.</creatorcontrib><creatorcontrib>Muniz, Igor P.R.</creatorcontrib><creatorcontrib>Santos, Gilvanéia S.</creatorcontrib><creatorcontrib>Silva, Robson A.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribeiro, Israel S.</au><au>Pereira, Ítalo S.</au><au>Galantini, Maria P.L.</au><au>Santos, Denisar P.</au><au>Teles, Mauro F.</au><au>Muniz, Igor P.R.</au><au>Santos, Gilvanéia S.</au><au>Silva, Robson A.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2021-11</date><risdate>2021</risdate><volume>155</volume><spage>111558</spage><epage>111558</epage><pages>111558-111558</pages><artnum>111558</artnum><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>The aim of this study was to assess the influence of physical activity in inflammatory, biochemical and endocrine parameters of middle-aged and elderly men with Systemic Arterial Hypertension (SAH) and Type 2 Diabetes Mellitus (T2DM). The assessment was comprised by 77 male volunteers aged between 45 and 59 years old (middle-aged men) or 60 to 86 years old (elderly men), diagnosed with SAH and T2DM, assisted by Family Health Units in Vitória da Conquista, Bahia, Brazil. According to age and lifestyle (sedentary or practicing physical activity), these men were classified as middle-aged sedentary men, middle-aged physically active men, elderly sedentary men, or elderly physically active men. It was noticed that active elderly people with SAH and T2DM had a better inflammatory balance than sedentary middle-aged men, through the evaluation of the relationship between the cytokines IL-10/TNF-α, IL-10/IL-17A and IL-10/IFN-γ. Moreover, in the extended correlation analysis, a greater global balance was observed among anthropometric, blood pressure, biochemical and cytokine parameters. Physical activity beneficially modulates aging-related disease risk factors even in elderly individuals.
•The benefits of physical activity counterbalance aging harms' in T2DM and SAH men•Active elderly men have better inflammatory balance than sedentary middle-aged men.•IL-10 negatively modulates IL-17A, IFN-γ, IL-1β, and also reduces inflammaging.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>34547405</pmid><doi>10.1016/j.exger.2021.111558</doi><tpages>1</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Aging Cytokines Diabetes Mellitus, Type 2 Exercise Humans Hypertension Inflammation - prevention & control Life Style Male Men Middle Aged Physical activity Systemic arterial hypertension Type 2 diabetes mellitus |
| title | Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men |
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