Inhibitory effect of hederagenin on Streptococcus pneumoniae pneumolysin in vitro

Streptococcus pneumoniae is an important pathogen that causes otitis media, pneumonia, meningitis and bacteremia. As an important virulence factors of S. pneumoniae, pneumolysin (PLY) can penetrate cell membranes and lead to cell lysis and inflammation, which is one of the main causes of infection a...

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Veröffentlicht in:	Microbes and infection 2022-03, Vol.24 (2), p.104888-104888, Article 104888
Hauptverfasser:	Ding, Rui, Zhang, Yan, Xu, Xiangzhu, Hou, Yunfeng, Nie, Jing, Deng, Xuming, Qiu, Jiazhang, Lv, Qianghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-virulence Bacterial Proteins - metabolism Hederagenin Humans Oleanolic Acid - analogs & derivatives Pneumococcal Infections - drug therapy Pneumolysin Streptococcus pneumoniae Streptolysins - metabolism
Online-Zugang:	Volltext
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