Synthesis, characterization and antitumor mechanism investigation of ruthenium(II) polypyridyl complexes with artesunate moiety

Six artesunate (ART) conjugated ruthenium(II) complexes (Ru(II)-ART conjugates) with the formula [Ru(N^N) 2 bpy(4-CH 3 -4′-CH 2 OART)](PF 6 ) 2 ( Ru-ART-1-3 ) and [Ru(N^N) 2 bpy(4-CH 2 OART-4′-CH 2 OART)](PF 6 ) 2 ( Ru-ART-4 – 6 ) (N^N = 2,2′-bipyridine (bpy, in Ru-ART-1 and Ru-ART-4 ), 1,10-phenant...

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