Harmaline isolated from Peganum harmala suppresses growth of esophageal squamous cell carcinoma through targeting mTOR

Harmaline is a naturally occurring β‐carboline alkaloid that is isolated from Peganum harmala. It has shown efficacy in treating Parkinson's disease and has been reported to exhibit antimicrobial and anticancer properties. However, the molecular mechanism of harmaline in the context of esophage...

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Veröffentlicht in:	Phytotherapy research 2021-11, Vol.35 (11), p.6377-6388
Hauptverfasser:	Zhang, Yuanyuan, Shi, Xiaodan, Xie, Xiaomeng, Laster, Kyle Vaughn, Pang, Mengjun, Liu, Kangdong, Hwang, Joonsung, Kim, Dong Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antiinfectives and antibacterials Cell growth Cell proliferation Depletion Esophageal cancer esophageal squamous cell carcinoma Esophagus Harmaline Kinases Movement disorders mTOR Neurodegenerative diseases Oral administration Parkinson's disease patient‐derived xenograft Peganum harmala Phosphorylation Rapamycin Squamous cell carcinoma TOR protein Tumors
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