Evolution and progression of Barrett’s oesophagus to oesophageal cancer

Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection and population expansion. Early steps in this process are driven by a set of mutated driver genes and structural alterations to the genome through copy number gains or losses. Oesophageal adenocarcinoma (EAC) and...

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Veröffentlicht in:	Nature reviews. Cancer 2021-11, Vol.21 (11), p.731-741
Hauptverfasser:	Killcoyne, Sarah, Fitzgerald, Rebecca C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1504/1477 631/67/2322 631/67/69 Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Barrett Esophagus - genetics Barrett Esophagus - pathology Barrett's esophagus Biomedical and Life Sciences Biomedicine Cancer Cancer Research Copy number Development and progression Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophagus Evolution Gene mutations Genetic aspects Genomic instability Humans Invasiveness Molecular evolution Mutation Oncology, Experimental Review Article
Online-Zugang:	Volltext
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