Understanding memory B cell selection

•Plasma and memory B cells have distinct objectives during affinity maturation.•Memory B cells are optimized to handle slightly mutated antigens.•Naive B cells provide the best initial conditions for significantly mutated antigens.•Simulations show tradeoffs of plasma, memory, and naive B cells for...

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Veröffentlicht in:	Journal of theoretical biology 2021-12, Vol.531, p.110905-110905, Article 110905
Hauptverfasser:	Lindsly, Stephen, Gupta, Maya, Stansbury, Cooper, Rajapakse, Indika
Format:	Artikel
Sprache:	eng
Schlagworte:	Adversarial mutation Germinal center Memory B cell Plasma B cell Warm start
Online-Zugang:	Volltext
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