Response of heavy metal and antibiotic resistance genes and related microorganisms to different heavy metals in activated sludge
With the recent growing interest of antibiotic resistance genes (ARGs) and their co-selection with heavy metal resistance genes (HMRGs), their relationship to heavy metals needs further analysis. This study examined the response of heavy metal resistant microorganisms (HMRMs) and antibiotic resistan...
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| Veröffentlicht in: | Journal of environmental management 2021-12, Vol.300, p.113754-113754, Article 113754 |
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| creator | Sun, Fulin Xu, Zhantang Fan, Leilei |
| description | With the recent growing interest of antibiotic resistance genes (ARGs) and their co-selection with heavy metal resistance genes (HMRGs), their relationship to heavy metals needs further analysis. This study examined the response of heavy metal resistant microorganisms (HMRMs) and antibiotic resistant microorganisms (ARMs) and their resistance genes (HMRGs and ARGs) to Cu and Cr stresses using metagenome. Results showed that Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Deltaproteobacteria, and Nitrospirae are the dominant HMRMs and ARMs, with majority of HMRMs taxa presenting changes similar to ARMs under heavy metal stresses. Types of HMRGs and ARGs changed (increased or decreased) under Cu and Cr stresses, and a significant relationship was noted between HMRGs and ARGs and their related microbe (p |
| doi_str_mv | 10.1016/j.jenvman.2021.113754 |
| format | Article |
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[Display omitted]
•Metagenomic analysis of Cu and Cr stresses on resistance gene and their related microbe.•Changes of HMRMs and ARMs are significantly induced by different heavy metals.•Significant relationship was noted between HMRGs and ARGs and their related microbial community.•Microbial communities are the main factor driving the diversity and abundance of HMRGs and ARGs.</description><identifier>ISSN: 0301-4797</identifier><identifier>EISSN: 1095-8630</identifier><identifier>DOI: 10.1016/j.jenvman.2021.113754</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Antibiotic resistance genes ; Antibiotic resistant microorganisms ; Heavy metal ; Heavy metal resistance genes ; Heavy metal resistant microorganisms</subject><ispartof>Journal of environmental management, 2021-12, Vol.300, p.113754-113754, Article 113754</ispartof><rights>2021 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-b13a59c1c84505972466c71a4d6e240c6453e917bd3f4d0835d1a4c5991f14c73</citedby><cites>FETCH-LOGICAL-c342t-b13a59c1c84505972466c71a4d6e240c6453e917bd3f4d0835d1a4c5991f14c73</cites><orcidid>0000-0003-3373-3000</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jenvman.2021.113754$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids></links><search><creatorcontrib>Sun, Fulin</creatorcontrib><creatorcontrib>Xu, Zhantang</creatorcontrib><creatorcontrib>Fan, Leilei</creatorcontrib><title>Response of heavy metal and antibiotic resistance genes and related microorganisms to different heavy metals in activated sludge</title><title>Journal of environmental management</title><description>With the recent growing interest of antibiotic resistance genes (ARGs) and their co-selection with heavy metal resistance genes (HMRGs), their relationship to heavy metals needs further analysis. This study examined the response of heavy metal resistant microorganisms (HMRMs) and antibiotic resistant microorganisms (ARMs) and their resistance genes (HMRGs and ARGs) to Cu and Cr stresses using metagenome. Results showed that Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Deltaproteobacteria, and Nitrospirae are the dominant HMRMs and ARMs, with majority of HMRMs taxa presenting changes similar to ARMs under heavy metal stresses. Types of HMRGs and ARGs changed (increased or decreased) under Cu and Cr stresses, and a significant relationship was noted between HMRGs and ARGs and their related microbe (p < 0.05). Network analysis revealed synergistic relationships between majority of HMRGs and ARGs; however, negative correlations were also noted between them. Co-occurrence of HMRGs and ARGs was mainly observed in chromosomes, and plasmids were found to provide limited opportunities for heavy metals to promote antibiotic resistance through co-selection. These findings imply that the response of HMRMs and ARMs is induced by heavy metals, and that the changes in these microbial communities are the main factor driving the diversity and abundance of HMRGs and ARGs.
[Display omitted]
•Metagenomic analysis of Cu and Cr stresses on resistance gene and their related microbe.•Changes of HMRMs and ARMs are significantly induced by different heavy metals.•Significant relationship was noted between HMRGs and ARGs and their related microbial community.•Microbial communities are the main factor driving the diversity and abundance of HMRGs and ARGs.</description><subject>Antibiotic resistance genes</subject><subject>Antibiotic resistant microorganisms</subject><subject>Heavy metal</subject><subject>Heavy metal resistance genes</subject><subject>Heavy metal resistant microorganisms</subject><issn>0301-4797</issn><issn>1095-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkM9LHDEUx0Op0K31TxBy9DLbvEky2TkVEWsFQRB7DtnkzTbLTLLmZRe89U93dD148_B4h-8P-H4YOwexBAHdz-1yi-kwubRsRQtLAGm0-sIWIHrdrDopvrKFkAIaZXrzjX0n2gohZAtmwf4_IO1yIuR54P_QHZ75hNWN3KUwX43rmGv0vCBFqi555BtMSG96wdFVDHyKvuRcNi5FmojXzEMcBiyY6sdO4jFx52s8vKVo3IcN_mAnwyzh2fs_ZX9_Xz9e_Wnu7m9ury7vGi9VW5s1SKd7D36ltNC9aVXXeQNOhQ5bJXyntMQezDrIQQWxkjrMotd9DwMob-Qpuzj27kp-2iNVO0XyOI4uYd6TbbXRotMa2tmqj9Z5FVHBwe5KnFx5tiDsK3G7te_E7StxeyQ-534dczjvOEQslnzEGVmIBX21IcdPGl4AXu2OTw</recordid><startdate>20211215</startdate><enddate>20211215</enddate><creator>Sun, Fulin</creator><creator>Xu, Zhantang</creator><creator>Fan, Leilei</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3373-3000</orcidid></search><sort><creationdate>20211215</creationdate><title>Response of heavy metal and antibiotic resistance genes and related microorganisms to different heavy metals in activated sludge</title><author>Sun, Fulin ; Xu, Zhantang ; Fan, Leilei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-b13a59c1c84505972466c71a4d6e240c6453e917bd3f4d0835d1a4c5991f14c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antibiotic resistance genes</topic><topic>Antibiotic resistant microorganisms</topic><topic>Heavy metal</topic><topic>Heavy metal resistance genes</topic><topic>Heavy metal resistant microorganisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Fulin</creatorcontrib><creatorcontrib>Xu, Zhantang</creatorcontrib><creatorcontrib>Fan, Leilei</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of environmental management</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Fulin</au><au>Xu, Zhantang</au><au>Fan, Leilei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of heavy metal and antibiotic resistance genes and related microorganisms to different heavy metals in activated sludge</atitle><jtitle>Journal of environmental management</jtitle><date>2021-12-15</date><risdate>2021</risdate><volume>300</volume><spage>113754</spage><epage>113754</epage><pages>113754-113754</pages><artnum>113754</artnum><issn>0301-4797</issn><eissn>1095-8630</eissn><abstract>With the recent growing interest of antibiotic resistance genes (ARGs) and their co-selection with heavy metal resistance genes (HMRGs), their relationship to heavy metals needs further analysis. This study examined the response of heavy metal resistant microorganisms (HMRMs) and antibiotic resistant microorganisms (ARMs) and their resistance genes (HMRGs and ARGs) to Cu and Cr stresses using metagenome. Results showed that Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Deltaproteobacteria, and Nitrospirae are the dominant HMRMs and ARMs, with majority of HMRMs taxa presenting changes similar to ARMs under heavy metal stresses. Types of HMRGs and ARGs changed (increased or decreased) under Cu and Cr stresses, and a significant relationship was noted between HMRGs and ARGs and their related microbe (p < 0.05). Network analysis revealed synergistic relationships between majority of HMRGs and ARGs; however, negative correlations were also noted between them. Co-occurrence of HMRGs and ARGs was mainly observed in chromosomes, and plasmids were found to provide limited opportunities for heavy metals to promote antibiotic resistance through co-selection. These findings imply that the response of HMRMs and ARMs is induced by heavy metals, and that the changes in these microbial communities are the main factor driving the diversity and abundance of HMRGs and ARGs.
[Display omitted]
•Metagenomic analysis of Cu and Cr stresses on resistance gene and their related microbe.•Changes of HMRMs and ARMs are significantly induced by different heavy metals.•Significant relationship was noted between HMRGs and ARGs and their related microbial community.•Microbial communities are the main factor driving the diversity and abundance of HMRGs and ARGs.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.jenvman.2021.113754</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3373-3000</orcidid></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Antibiotic resistance genes Antibiotic resistant microorganisms Heavy metal Heavy metal resistance genes Heavy metal resistant microorganisms |
| title | Response of heavy metal and antibiotic resistance genes and related microorganisms to different heavy metals in activated sludge |
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