Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration
[Display omitted] The human eye is a complex organ with unique anatomy and physiology that restricts the delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy, biotechnology and material science have led to development of novel ophthalmic dosage forms which can p...
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| Veröffentlicht in: | International journal of pharmaceutics 2021-10, Vol.608, p.121105-121105, Article 121105 |
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| container_end_page | 121105 |
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| container_start_page | 121105 |
| container_title | International journal of pharmaceutics |
| container_volume | 608 |
| creator | Maulvi, Furqan A. Shetty, Kiran H. Desai, Ditixa T. Shah, Dinesh O. Willcox, Mark D.P. |
| description | [Display omitted]
The human eye is a complex organ with unique anatomy and physiology that restricts the delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy, biotechnology and material science have led to development of novel ophthalmic dosage forms which can provide sustained drug delivery, reduce dosing frequency and improve the ocular bioavailability of drugs. This review highlights the different anatomical and physiological factors which affect ocular bioavailability of drugs and explores advancements from 2016 to 2020 in various ophthalmic preparations. Different routes of drug administration such as topical, intravitreal, intraocular, juxtascleral, subconjunctival, intracameral and retrobulbar are discussed with their advances and limitations. |
| doi_str_mv | 10.1016/j.ijpharm.2021.121105 |
| format | Article |
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The human eye is a complex organ with unique anatomy and physiology that restricts the delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy, biotechnology and material science have led to development of novel ophthalmic dosage forms which can provide sustained drug delivery, reduce dosing frequency and improve the ocular bioavailability of drugs. This review highlights the different anatomical and physiological factors which affect ocular bioavailability of drugs and explores advancements from 2016 to 2020 in various ophthalmic preparations. Different routes of drug administration such as topical, intravitreal, intraocular, juxtascleral, subconjunctival, intracameral and retrobulbar are discussed with their advances and limitations.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2021.121105</identifier><identifier>PMID: 34537269</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Ophthalmic ; Biological Availability ; Drug administration ; Drug Delivery Systems ; Eye ; Eye Diseases - drug therapy ; Humans ; Ocular barriers ; Ophthalmic preparations ; Ophthalmic Solutions ; Pharmaceutical Preparations</subject><ispartof>International journal of pharmaceutics, 2021-10, Vol.608, p.121105-121105, Article 121105</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-2ff578d6aa66232d0707b9fde454a93a097be42be5bdd4ce67e6803002ab95403</citedby><cites>FETCH-LOGICAL-c412t-2ff578d6aa66232d0707b9fde454a93a097be42be5bdd4ce67e6803002ab95403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037851732100911X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34537269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maulvi, Furqan A.</creatorcontrib><creatorcontrib>Shetty, Kiran H.</creatorcontrib><creatorcontrib>Desai, Ditixa T.</creatorcontrib><creatorcontrib>Shah, Dinesh O.</creatorcontrib><creatorcontrib>Willcox, Mark D.P.</creatorcontrib><title>Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
The human eye is a complex organ with unique anatomy and physiology that restricts the delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy, biotechnology and material science have led to development of novel ophthalmic dosage forms which can provide sustained drug delivery, reduce dosing frequency and improve the ocular bioavailability of drugs. This review highlights the different anatomical and physiological factors which affect ocular bioavailability of drugs and explores advancements from 2016 to 2020 in various ophthalmic preparations. Different routes of drug administration such as topical, intravitreal, intraocular, juxtascleral, subconjunctival, intracameral and retrobulbar are discussed with their advances and limitations.</description><subject>Administration, Ophthalmic</subject><subject>Biological Availability</subject><subject>Drug administration</subject><subject>Drug Delivery Systems</subject><subject>Eye</subject><subject>Eye Diseases - drug therapy</subject><subject>Humans</subject><subject>Ocular barriers</subject><subject>Ophthalmic preparations</subject><subject>Ophthalmic Solutions</subject><subject>Pharmaceutical Preparations</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAUhUVJaaZpf0KDllnUU71lZxNK6AsCgdKuxbV03dFgW45kB_rv6-BJtl3dzXfO4X6EfOBszxk3n477eJwOkIe9YILvueCc6Vdkx2srK6msOSM7Jm1daW7lOXlbypExZgSXb8i5VFpaYZod6X6ix3GmEB5h9FhoHGmaDvMB-iF6OmWcIMMc01iu6b1fesi0hZwj5vKRhlTgD9Iu5aFQGAPNaZnXktSthUMcY5m38DvyuoO-4PvTvSC_v375dfu9urv_9uP2813lFRdzJbpO2zoYAGOEFIFZZtumC6i0gkYCa2yLSrSo2xCUR2PR1EwyJqBttGLyglxtvVNODwuW2Q2xeOx7GDEtxQltlVWytmZF9Yb6nErJ2LkpxwHyX8eZe1Lsju6k2D0pdpviNXd5mljaAcNL6tnpCtxsAK6PPq6iXPERV7khZvSzCyn-Z-IfrheQyQ</recordid><startdate>20211025</startdate><enddate>20211025</enddate><creator>Maulvi, Furqan A.</creator><creator>Shetty, Kiran H.</creator><creator>Desai, Ditixa T.</creator><creator>Shah, Dinesh O.</creator><creator>Willcox, Mark D.P.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211025</creationdate><title>Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration</title><author>Maulvi, Furqan A. ; Shetty, Kiran H. ; Desai, Ditixa T. ; Shah, Dinesh O. ; Willcox, Mark D.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-2ff578d6aa66232d0707b9fde454a93a097be42be5bdd4ce67e6803002ab95403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Administration, Ophthalmic</topic><topic>Biological Availability</topic><topic>Drug administration</topic><topic>Drug Delivery Systems</topic><topic>Eye</topic><topic>Eye Diseases - drug therapy</topic><topic>Humans</topic><topic>Ocular barriers</topic><topic>Ophthalmic preparations</topic><topic>Ophthalmic Solutions</topic><topic>Pharmaceutical Preparations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maulvi, Furqan A.</creatorcontrib><creatorcontrib>Shetty, Kiran H.</creatorcontrib><creatorcontrib>Desai, Ditixa T.</creatorcontrib><creatorcontrib>Shah, Dinesh O.</creatorcontrib><creatorcontrib>Willcox, Mark D.P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maulvi, Furqan A.</au><au>Shetty, Kiran H.</au><au>Desai, Ditixa T.</au><au>Shah, Dinesh O.</au><au>Willcox, Mark D.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2021-10-25</date><risdate>2021</risdate><volume>608</volume><spage>121105</spage><epage>121105</epage><pages>121105-121105</pages><artnum>121105</artnum><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2021-10, Vol.608, p.121105-121105, Article 121105 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Ophthalmic Biological Availability Drug administration Drug Delivery Systems Eye Eye Diseases - drug therapy Humans Ocular barriers Ophthalmic preparations Ophthalmic Solutions Pharmaceutical Preparations |
| title | Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration |
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