Anti-inflammatory effects of tibial axial loading on knee articular cartilage post traumatic injury

Early therapeutic intervention to mitigate inflammatory responses following joint injury may offer a potential strategy to prevent post-traumatic osteoarthritis (PTOA). In-vitro studies have demonstrated uniaxial dynamic compression mitigates the catabolic and apoptotic responses of articular cartil...

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Veröffentlicht in:	Journal of biomechanics 2021-11, Vol.128, p.110736-110736, Article 110736
Hauptverfasser:	Hazbun, Larry, Martinez, Jose A., Best, Thomas M., Kaplan, Lee, Huang, Chun-Yuh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anti-Inflammatory Agents Apoptosis Articular cartilage Axial loads Biomedical materials Body weight Cartilage Cartilage diseases Cartilage, Articular Compression Computer applications Cytokines Dynamic joint loading Feedback control systems Gene expression IL-1β Impact injury Inflammation Inflammatory response Injury analysis Injury prevention Joint and ligament injuries Joints (anatomy) Knee Knee Injuries Knee Joint Mimicry Osteoarthritis Physiology Pressure distribution Swine Tumor necrosis factor-TNF Tumor necrosis factor-α Weight-Bearing
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