Effect of Nitinol on Metabolic and Coagulation Activity of Endothelial Cells Culture

We studied the effect of nitinol, the most prevalent material for endovascular stents, on metabolic and coagulation activity of a primary culture of human umbilical vein endothelial cells (HUVEC). Metabolic activity was evaluated using MTS-test and by the level of stable NO metabolites in the condit...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2021-08, Vol.171 (4), p.480-482
Hauptverfasser:	Kalinin, R. E., Suchkov, I. A., Mzhavanadze, N. D., Korotkova, N. V., Zhurina, O. N., Povarov, V. O., Surov, I. Yu, Bozhenova, A. D., Strelnikova, E. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloys - pharmacology Analysis Biomedical and Life Sciences Biomedicine Biotechnologies Blood Coagulation - drug effects Blood Coagulation Factors - metabolism Cardiovascular system Cell Biology Cell culture Cells, Cultured Coagulation Endothelial cells Endothelial Protein C Receptor - drug effects Endothelial Protein C Receptor - metabolism Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - physiology Humans Implants Internal Medicine Laboratory Medicine Metabolism Metabolites Nickel alloys Pathology Plasminogen Activator Inhibitor 1 - drug effects Plasminogen Activator Inhibitor 1 - metabolism Plasminogen activator inhibitors Protein C Statistical analysis Stent (Surgery) Thrombosis - metabolism Thrombosis - pathology Umbilical vein Von Willebrand factor von Willebrand Factor - drug effects von Willebrand Factor - metabolism
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Zusammenfassung:	We studied the effect of nitinol, the most prevalent material for endovascular stents, on metabolic and coagulation activity of a primary culture of human umbilical vein endothelial cells (HUVEC). Metabolic activity was evaluated using MTS-test and by the level of stable NO metabolites in the conditioned medium, coagulation activity was assessed by activity of von Willebrand factor (vWF) and levels of plasminogen activator inhibitor-1 (PAI-1) and soluble endothelial protein C receptors (sEPCR). Exposure to nitinol reduced metabolic activity of the cell culture by 11.1% in comparison with the control ( p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-021-05255-8