Role of diabetes in stroke: Recent advances in pathophysiology and clinical management
The increasing prevalence of diabetes and stroke is a major global public health concern. Specifically, acute stroke patients, with pre‐existing diabetes, pose a clinical challenge. It is established that diabetes is associated with a worse prognosis after acute stroke and the various biological fac...
Gespeichert in:
| Veröffentlicht in: | Diabetes/metabolism research and reviews 2022-02, Vol.38 (2), p.e3495-n/a |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 2 |
| container_start_page | e3495 |
| container_title | Diabetes/metabolism research and reviews |
| container_volume | 38 |
| creator | Bradley, Sian A. Spring, Kevin J. Beran, Roy G. Chatzis, Dimitrios Killingsworth, Murray C. Bhaskar, Sonu M. M. |
| description | The increasing prevalence of diabetes and stroke is a major global public health concern. Specifically, acute stroke patients, with pre‐existing diabetes, pose a clinical challenge. It is established that diabetes is associated with a worse prognosis after acute stroke and the various biological factors that mediate poor recovery profiles in diabetic patients is unknown. The level of association and impact of diabetes, in the setting of reperfusion therapy, is yet to be determined. This article presents a comprehensive overview of the current knowledge of the role of diabetes in stroke, therapeutic strategies for primary and secondary prevention of cardiovascular disease and/or stroke in diabetes, and various therapeutic considerations that may apply during pre‐stroke, acute, sub‐acute and post‐stroke stages. The early diagnosis of diabetes as a comorbidity for stroke, as well as tailored post‐stroke management of diabetes, is pivotal to our efforts to limit the burden. Increasing awareness and involvement of neurologists in the management of diabetes and other cardiovascular risk factors is desirable towards improving stroke prevention and efficacy of reperfusion therapy in acute stroke patients with diabetes. |
| doi_str_mv | 10.1002/dmrr.3495 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2574409193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2574409193</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3535-7f0b96dc95e1a442163e9f56ce97fb366c3fe0e4818010d7ce85490051d9e6853</originalsourceid><addsrcrecordid>eNp1kMtKAzEUQIMoWh8Lf0ACbnTR9mbymIk78Q0VoajbkGbu1NGZSU2mSv_eqa0uBFe5kHMPl0PIIYMBA0iGeR3CgAstN0iPyQT6qVSw-TvLZIfsxvgKAFwosU12uJAcRCZ75HnsK6S-oHlpJ9hipGVDYxv8G57RMTpsWmrzD9u41dfMti9-9rKIpa_8dEFtk1NXlU3pbEVr29gp1t3OPtkqbBXxYP3ukafrq8eL2_7o4ebu4nzUd1xy2U8LmGiVOy2RWSESpjjqQiqHOi0mXCnHCwQUGcuAQZ46zKTQAJLlGlUm-R45WXlnwb_PMbamLqPDqrIN-nk0iUyFAM0079DjP-irn4emu84kKhEpyESKjjpdUS74GAMWZhbK2oaFYWCWsc0ytlnG7tijtXE-qTH_JX_qdsBwBXyWFS7-N5nL-_H4W_kFRNiIQA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2624705254</pqid></control><display><type>article</type><title>Role of diabetes in stroke: Recent advances in pathophysiology and clinical management</title><source>MEDLINE</source><source>Wiley Online Library</source><creator>Bradley, Sian A. ; Spring, Kevin J. ; Beran, Roy G. ; Chatzis, Dimitrios ; Killingsworth, Murray C. ; Bhaskar, Sonu M. M.</creator><creatorcontrib>Bradley, Sian A. ; Spring, Kevin J. ; Beran, Roy G. ; Chatzis, Dimitrios ; Killingsworth, Murray C. ; Bhaskar, Sonu M. M.</creatorcontrib><description>The increasing prevalence of diabetes and stroke is a major global public health concern. Specifically, acute stroke patients, with pre‐existing diabetes, pose a clinical challenge. It is established that diabetes is associated with a worse prognosis after acute stroke and the various biological factors that mediate poor recovery profiles in diabetic patients is unknown. The level of association and impact of diabetes, in the setting of reperfusion therapy, is yet to be determined. This article presents a comprehensive overview of the current knowledge of the role of diabetes in stroke, therapeutic strategies for primary and secondary prevention of cardiovascular disease and/or stroke in diabetes, and various therapeutic considerations that may apply during pre‐stroke, acute, sub‐acute and post‐stroke stages. The early diagnosis of diabetes as a comorbidity for stroke, as well as tailored post‐stroke management of diabetes, is pivotal to our efforts to limit the burden. Increasing awareness and involvement of neurologists in the management of diabetes and other cardiovascular risk factors is desirable towards improving stroke prevention and efficacy of reperfusion therapy in acute stroke patients with diabetes.</description><identifier>ISSN: 1520-7552</identifier><identifier>EISSN: 1520-7560</identifier><identifier>DOI: 10.1002/dmrr.3495</identifier><identifier>PMID: 34530485</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; cerebrovascular disease ; Comorbidity ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Humans ; Medical prognosis ; pathophysiology ; Patients ; prognosis ; Public health ; Reperfusion ; reperfusion therapy ; Risk factors ; Stroke ; Stroke - etiology ; Stroke - prevention & control</subject><ispartof>Diabetes/metabolism research and reviews, 2022-02, Vol.38 (2), p.e3495-n/a</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-7f0b96dc95e1a442163e9f56ce97fb366c3fe0e4818010d7ce85490051d9e6853</citedby><cites>FETCH-LOGICAL-c3535-7f0b96dc95e1a442163e9f56ce97fb366c3fe0e4818010d7ce85490051d9e6853</cites><orcidid>0000-0002-9783-3628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdmrr.3495$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdmrr.3495$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34530485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bradley, Sian A.</creatorcontrib><creatorcontrib>Spring, Kevin J.</creatorcontrib><creatorcontrib>Beran, Roy G.</creatorcontrib><creatorcontrib>Chatzis, Dimitrios</creatorcontrib><creatorcontrib>Killingsworth, Murray C.</creatorcontrib><creatorcontrib>Bhaskar, Sonu M. M.</creatorcontrib><title>Role of diabetes in stroke: Recent advances in pathophysiology and clinical management</title><title>Diabetes/metabolism research and reviews</title><addtitle>Diabetes Metab Res Rev</addtitle><description>The increasing prevalence of diabetes and stroke is a major global public health concern. Specifically, acute stroke patients, with pre‐existing diabetes, pose a clinical challenge. It is established that diabetes is associated with a worse prognosis after acute stroke and the various biological factors that mediate poor recovery profiles in diabetic patients is unknown. The level of association and impact of diabetes, in the setting of reperfusion therapy, is yet to be determined. This article presents a comprehensive overview of the current knowledge of the role of diabetes in stroke, therapeutic strategies for primary and secondary prevention of cardiovascular disease and/or stroke in diabetes, and various therapeutic considerations that may apply during pre‐stroke, acute, sub‐acute and post‐stroke stages. The early diagnosis of diabetes as a comorbidity for stroke, as well as tailored post‐stroke management of diabetes, is pivotal to our efforts to limit the burden. Increasing awareness and involvement of neurologists in the management of diabetes and other cardiovascular risk factors is desirable towards improving stroke prevention and efficacy of reperfusion therapy in acute stroke patients with diabetes.</description><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>cerebrovascular disease</subject><subject>Comorbidity</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>pathophysiology</subject><subject>Patients</subject><subject>prognosis</subject><subject>Public health</subject><subject>Reperfusion</subject><subject>reperfusion therapy</subject><subject>Risk factors</subject><subject>Stroke</subject><subject>Stroke - etiology</subject><subject>Stroke - prevention & control</subject><issn>1520-7552</issn><issn>1520-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUQIMoWh8Lf0ACbnTR9mbymIk78Q0VoajbkGbu1NGZSU2mSv_eqa0uBFe5kHMPl0PIIYMBA0iGeR3CgAstN0iPyQT6qVSw-TvLZIfsxvgKAFwosU12uJAcRCZ75HnsK6S-oHlpJ9hipGVDYxv8G57RMTpsWmrzD9u41dfMti9-9rKIpa_8dEFtk1NXlU3pbEVr29gp1t3OPtkqbBXxYP3ukafrq8eL2_7o4ebu4nzUd1xy2U8LmGiVOy2RWSESpjjqQiqHOi0mXCnHCwQUGcuAQZ46zKTQAJLlGlUm-R45WXlnwb_PMbamLqPDqrIN-nk0iUyFAM0079DjP-irn4emu84kKhEpyESKjjpdUS74GAMWZhbK2oaFYWCWsc0ytlnG7tijtXE-qTH_JX_qdsBwBXyWFS7-N5nL-_H4W_kFRNiIQA</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Bradley, Sian A.</creator><creator>Spring, Kevin J.</creator><creator>Beran, Roy G.</creator><creator>Chatzis, Dimitrios</creator><creator>Killingsworth, Murray C.</creator><creator>Bhaskar, Sonu M. M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9783-3628</orcidid></search><sort><creationdate>202202</creationdate><title>Role of diabetes in stroke: Recent advances in pathophysiology and clinical management</title><author>Bradley, Sian A. ; Spring, Kevin J. ; Beran, Roy G. ; Chatzis, Dimitrios ; Killingsworth, Murray C. ; Bhaskar, Sonu M. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-7f0b96dc95e1a442163e9f56ce97fb366c3fe0e4818010d7ce85490051d9e6853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>cerebrovascular disease</topic><topic>Comorbidity</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>pathophysiology</topic><topic>Patients</topic><topic>prognosis</topic><topic>Public health</topic><topic>Reperfusion</topic><topic>reperfusion therapy</topic><topic>Risk factors</topic><topic>Stroke</topic><topic>Stroke - etiology</topic><topic>Stroke - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bradley, Sian A.</creatorcontrib><creatorcontrib>Spring, Kevin J.</creatorcontrib><creatorcontrib>Beran, Roy G.</creatorcontrib><creatorcontrib>Chatzis, Dimitrios</creatorcontrib><creatorcontrib>Killingsworth, Murray C.</creatorcontrib><creatorcontrib>Bhaskar, Sonu M. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes/metabolism research and reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bradley, Sian A.</au><au>Spring, Kevin J.</au><au>Beran, Roy G.</au><au>Chatzis, Dimitrios</au><au>Killingsworth, Murray C.</au><au>Bhaskar, Sonu M. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of diabetes in stroke: Recent advances in pathophysiology and clinical management</atitle><jtitle>Diabetes/metabolism research and reviews</jtitle><addtitle>Diabetes Metab Res Rev</addtitle><date>2022-02</date><risdate>2022</risdate><volume>38</volume><issue>2</issue><spage>e3495</spage><epage>n/a</epage><pages>e3495-n/a</pages><issn>1520-7552</issn><eissn>1520-7560</eissn><abstract>The increasing prevalence of diabetes and stroke is a major global public health concern. Specifically, acute stroke patients, with pre‐existing diabetes, pose a clinical challenge. It is established that diabetes is associated with a worse prognosis after acute stroke and the various biological factors that mediate poor recovery profiles in diabetic patients is unknown. The level of association and impact of diabetes, in the setting of reperfusion therapy, is yet to be determined. This article presents a comprehensive overview of the current knowledge of the role of diabetes in stroke, therapeutic strategies for primary and secondary prevention of cardiovascular disease and/or stroke in diabetes, and various therapeutic considerations that may apply during pre‐stroke, acute, sub‐acute and post‐stroke stages. The early diagnosis of diabetes as a comorbidity for stroke, as well as tailored post‐stroke management of diabetes, is pivotal to our efforts to limit the burden. Increasing awareness and involvement of neurologists in the management of diabetes and other cardiovascular risk factors is desirable towards improving stroke prevention and efficacy of reperfusion therapy in acute stroke patients with diabetes.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34530485</pmid><doi>10.1002/dmrr.3495</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-9783-3628</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1520-7552 |
| ispartof | Diabetes/metabolism research and reviews, 2022-02, Vol.38 (2), p.e3495-n/a |
| issn | 1520-7552 1520-7560 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2574409193 |
| source | MEDLINE; Wiley Online Library |
| subjects | Cardiovascular diseases Cardiovascular Diseases - epidemiology cerebrovascular disease Comorbidity Diabetes Diabetes mellitus Diabetes Mellitus - epidemiology Humans Medical prognosis pathophysiology Patients prognosis Public health Reperfusion reperfusion therapy Risk factors Stroke Stroke - etiology Stroke - prevention & control |
| title | Role of diabetes in stroke: Recent advances in pathophysiology and clinical management |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T16%3A26%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20diabetes%20in%20stroke:%20Recent%20advances%20in%20pathophysiology%20and%20clinical%20management&rft.jtitle=Diabetes/metabolism%20research%20and%20reviews&rft.au=Bradley,%20Sian%20A.&rft.date=2022-02&rft.volume=38&rft.issue=2&rft.spage=e3495&rft.epage=n/a&rft.pages=e3495-n/a&rft.issn=1520-7552&rft.eissn=1520-7560&rft_id=info:doi/10.1002/dmrr.3495&rft_dat=%3Cproquest_cross%3E2574409193%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2624705254&rft_id=info:pmid/34530485&rfr_iscdi=true |