Functional and structural alternations in the choroid plexus upon methamphetamine exposure

•METH treatment increased the total volume of the choroid plexus.•Methamphetamine changed the ultrastructure of choroid plexus epithelial cells.•METH administration increased the mRNA level of autophagy, inflammation and apoptosis genes.•METH Administration did not alter caspase-3 protein level. Cho...

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Veröffentlicht in:	Neuroscience letters 2021-11, Vol.764, p.136246-136246, Article 136246
Hauptverfasser:	Hassani Moghaddam, Meysam, Eskandarian Boroujeni, Mahdi, Vakili, Kimia, Fathi, Mobina, Abdollahifar, Mohammad-Amin, Eskandari, Neda, Esmaeilpour, Tahereh, Aliaghaei, Abbas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - genetics Autophagy Autophagy - drug effects Autophagy - genetics Brain-Derived Neurotrophic Factor - analysis Brain-Derived Neurotrophic Factor - metabolism Caspase 3 - analysis Caspase 3 - metabolism Central Nervous System Stimulants - administration & dosage Central Nervous System Stimulants - toxicity Choroid plexus Choroid Plexus - cytology Choroid Plexus - drug effects Choroid Plexus - pathology Differential gene expression Epithelial Cells - drug effects Epithelial Cells - pathology Epithelial Cells - ultrastructure Injections, Intraperitoneal Male Methamphetamine Methamphetamine - administration & dosage Methamphetamine - toxicity Microscopy, Electron, Transmission Rats RNA-seq Up-Regulation - drug effects Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - metabolism
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