Association between the albumin–bilirubin (ALBI) score and severity of portopulmonary hypertension (PoPH): A data‐mining analysis
Introduction Portopulmonary hypertension (PoPH) is a severe complication of chronic liver disease. We aimed to investigate the etiology of chronic liver disease and the factors associated with the severity of PoPH. Subjects and Methods Echocardiography was undergone in 833 patients with chronic live...
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| Veröffentlicht in: | Hepatology research 2021-12, Vol.51 (12), p.1207-1218 |
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| creator | Kawaguchi, Takumi Honda, Akihiro Sugiyama, Yoichi Nakano, Dan Tsutsumi, Tsubasa Tahara, Nobuhiro Torimura, Takuji Fukumoto, Yoshihiro |
| description | Introduction
Portopulmonary hypertension (PoPH) is a severe complication of chronic liver disease. We aimed to investigate the etiology of chronic liver disease and the factors associated with the severity of PoPH.
Subjects and Methods
Echocardiography was undergone in 833 patients with chronic liver disease during 2005–2019 and 13 patients (1.6%) were diagnosed with PoPH in this observational study. At the diagnosis of PoPH, liver function was evaluated by albumin–bilirubin (ALBI) score. Severe PoPH was defined as (1) mean pulmonary arterial pressure (mPAP) ≥50 mmHg or (2) mPAP: 35–49 mmHg and pulmonary vascular resistance ≥400 dyne/s/cm5. Factors associated with severe PoPH were evaluated by decision‐tree analysis.
Results
In patients with PoPH, the leading etiology of chronic liver disease was hepatitis C virus (HCV) (46.2% [sustained virological response (SVR): 23.1% and non‐SVR: 15.4%]). Severe PoPH was observed in 53.8% of patients and the 5‐year survival rate was 48.1%. There was a significant correlation of mPAP with ALBI score (r = 0.6456, p = 0.0171). In the decision‐tree and random forest analyses, the most impacted classifier for severe PoPH was the ALBI score. In patients with ALBI score ≥−1.45, all patients showed severe PoPH, while the prevalence of severe PoPH was 25.0% in patients with ALBI score |
| doi_str_mv | 10.1111/hepr.13714 |
| format | Article |
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Portopulmonary hypertension (PoPH) is a severe complication of chronic liver disease. We aimed to investigate the etiology of chronic liver disease and the factors associated with the severity of PoPH.
Subjects and Methods
Echocardiography was undergone in 833 patients with chronic liver disease during 2005–2019 and 13 patients (1.6%) were diagnosed with PoPH in this observational study. At the diagnosis of PoPH, liver function was evaluated by albumin–bilirubin (ALBI) score. Severe PoPH was defined as (1) mean pulmonary arterial pressure (mPAP) ≥50 mmHg or (2) mPAP: 35–49 mmHg and pulmonary vascular resistance ≥400 dyne/s/cm5. Factors associated with severe PoPH were evaluated by decision‐tree analysis.
Results
In patients with PoPH, the leading etiology of chronic liver disease was hepatitis C virus (HCV) (46.2% [sustained virological response (SVR): 23.1% and non‐SVR: 15.4%]). Severe PoPH was observed in 53.8% of patients and the 5‐year survival rate was 48.1%. There was a significant correlation of mPAP with ALBI score (r = 0.6456, p = 0.0171). In the decision‐tree and random forest analyses, the most impacted classifier for severe PoPH was the ALBI score. In patients with ALBI score ≥−1.45, all patients showed severe PoPH, while the prevalence of severe PoPH was 25.0% in patients with ALBI score <−1.45.
Conclusions
We found that HCV including SVR was the major etiology of chronic liver disease in patients with PoPH. Moreover, we revealed that the ALBI score was the most impacted factor associated with severe PoPH. Thus, ALBI score may be useful for the estimation of pulmonary vascular resistance.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.13714</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Albumin ; Bilirubin ; Blood pressure ; Echocardiography ; Etiology ; Hepatitis C ; hepatitis C virus ; Hypertension ; Liver diseases ; portopulmonary hypertension ; prognosis</subject><ispartof>Hepatology research, 2021-12, Vol.51 (12), p.1207-1218</ispartof><rights>2021 Japan Society of Hepatology.</rights><rights>2021 The Japan Society of Hepatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4004-14d9b2dcbd8eeacb6e2054403fe0b48bb80e8c63b41e66bf64836951229169293</citedby><cites>FETCH-LOGICAL-c4004-14d9b2dcbd8eeacb6e2054403fe0b48bb80e8c63b41e66bf64836951229169293</cites><orcidid>0000-0002-7064-4325 ; 0000-0001-6098-1224 ; 0000-0002-8947-109X ; 0000-0003-2011-8201 ; 0000-0001-6571-9874</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhepr.13714$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhepr.13714$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Kawaguchi, Takumi</creatorcontrib><creatorcontrib>Honda, Akihiro</creatorcontrib><creatorcontrib>Sugiyama, Yoichi</creatorcontrib><creatorcontrib>Nakano, Dan</creatorcontrib><creatorcontrib>Tsutsumi, Tsubasa</creatorcontrib><creatorcontrib>Tahara, Nobuhiro</creatorcontrib><creatorcontrib>Torimura, Takuji</creatorcontrib><creatorcontrib>Fukumoto, Yoshihiro</creatorcontrib><title>Association between the albumin–bilirubin (ALBI) score and severity of portopulmonary hypertension (PoPH): A data‐mining analysis</title><title>Hepatology research</title><description>Introduction
Portopulmonary hypertension (PoPH) is a severe complication of chronic liver disease. We aimed to investigate the etiology of chronic liver disease and the factors associated with the severity of PoPH.
Subjects and Methods
Echocardiography was undergone in 833 patients with chronic liver disease during 2005–2019 and 13 patients (1.6%) were diagnosed with PoPH in this observational study. At the diagnosis of PoPH, liver function was evaluated by albumin–bilirubin (ALBI) score. Severe PoPH was defined as (1) mean pulmonary arterial pressure (mPAP) ≥50 mmHg or (2) mPAP: 35–49 mmHg and pulmonary vascular resistance ≥400 dyne/s/cm5. Factors associated with severe PoPH were evaluated by decision‐tree analysis.
Results
In patients with PoPH, the leading etiology of chronic liver disease was hepatitis C virus (HCV) (46.2% [sustained virological response (SVR): 23.1% and non‐SVR: 15.4%]). Severe PoPH was observed in 53.8% of patients and the 5‐year survival rate was 48.1%. There was a significant correlation of mPAP with ALBI score (r = 0.6456, p = 0.0171). In the decision‐tree and random forest analyses, the most impacted classifier for severe PoPH was the ALBI score. In patients with ALBI score ≥−1.45, all patients showed severe PoPH, while the prevalence of severe PoPH was 25.0% in patients with ALBI score <−1.45.
Conclusions
We found that HCV including SVR was the major etiology of chronic liver disease in patients with PoPH. Moreover, we revealed that the ALBI score was the most impacted factor associated with severe PoPH. Thus, ALBI score may be useful for the estimation of pulmonary vascular resistance.</description><subject>Albumin</subject><subject>Bilirubin</subject><subject>Blood pressure</subject><subject>Echocardiography</subject><subject>Etiology</subject><subject>Hepatitis C</subject><subject>hepatitis C virus</subject><subject>Hypertension</subject><subject>Liver diseases</subject><subject>portopulmonary hypertension</subject><subject>prognosis</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kbFOwzAQhiMEElBYeAJLLAUpxY5dJ2ErVaGVKlEhkNgiO7lQo9QOdgLK1oUdiTfkSXApEwO33A3ffbrTHwQnBA-Ir4sl1HZAaEzYTnBAkjgKMWWPu36mCQ85ZXw_OHTuGWMS44gdBO8j50yuRKOMRhKaNwCNmiUgUcl2pfTX-lOqStlWKo36o_nV7Ay53FgP6AI5eAWrmg6ZEtXGNqZuq5XRwnZo2dVgG9BuI-4vzGJ6dolGqBCN-Fp_eLPST94hqs4pdxTslaJycPzbe8HD9eR-PA3ntzez8Wge5gxjFhJWpDIqclkkACKXHCI8ZAzTErBkiZQJhiTnVDICnMuSs4TydEiiKCU8jVLaC_pbb23NSwuuyVbK5VBVQoNpXRYNY69jaUo9evoHfTat9fd6imPG45QkzFPnWyq3xjkLZVZbtfL_ZwRnm0SyTSLZTyIeJlv4TVXQ_UNm08nibrvzDbTkkLk</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Kawaguchi, Takumi</creator><creator>Honda, Akihiro</creator><creator>Sugiyama, Yoichi</creator><creator>Nakano, Dan</creator><creator>Tsutsumi, Tsubasa</creator><creator>Tahara, Nobuhiro</creator><creator>Torimura, Takuji</creator><creator>Fukumoto, Yoshihiro</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7064-4325</orcidid><orcidid>https://orcid.org/0000-0001-6098-1224</orcidid><orcidid>https://orcid.org/0000-0002-8947-109X</orcidid><orcidid>https://orcid.org/0000-0003-2011-8201</orcidid><orcidid>https://orcid.org/0000-0001-6571-9874</orcidid></search><sort><creationdate>202112</creationdate><title>Association between the albumin–bilirubin (ALBI) score and severity of portopulmonary hypertension (PoPH): A data‐mining analysis</title><author>Kawaguchi, Takumi ; Honda, Akihiro ; Sugiyama, Yoichi ; Nakano, Dan ; Tsutsumi, Tsubasa ; Tahara, Nobuhiro ; Torimura, Takuji ; Fukumoto, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4004-14d9b2dcbd8eeacb6e2054403fe0b48bb80e8c63b41e66bf64836951229169293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Albumin</topic><topic>Bilirubin</topic><topic>Blood pressure</topic><topic>Echocardiography</topic><topic>Etiology</topic><topic>Hepatitis C</topic><topic>hepatitis C virus</topic><topic>Hypertension</topic><topic>Liver diseases</topic><topic>portopulmonary hypertension</topic><topic>prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawaguchi, Takumi</creatorcontrib><creatorcontrib>Honda, Akihiro</creatorcontrib><creatorcontrib>Sugiyama, Yoichi</creatorcontrib><creatorcontrib>Nakano, Dan</creatorcontrib><creatorcontrib>Tsutsumi, Tsubasa</creatorcontrib><creatorcontrib>Tahara, Nobuhiro</creatorcontrib><creatorcontrib>Torimura, Takuji</creatorcontrib><creatorcontrib>Fukumoto, Yoshihiro</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawaguchi, Takumi</au><au>Honda, Akihiro</au><au>Sugiyama, Yoichi</au><au>Nakano, Dan</au><au>Tsutsumi, Tsubasa</au><au>Tahara, Nobuhiro</au><au>Torimura, Takuji</au><au>Fukumoto, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between the albumin–bilirubin (ALBI) score and severity of portopulmonary hypertension (PoPH): A data‐mining analysis</atitle><jtitle>Hepatology research</jtitle><date>2021-12</date><risdate>2021</risdate><volume>51</volume><issue>12</issue><spage>1207</spage><epage>1218</epage><pages>1207-1218</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Introduction
Portopulmonary hypertension (PoPH) is a severe complication of chronic liver disease. We aimed to investigate the etiology of chronic liver disease and the factors associated with the severity of PoPH.
Subjects and Methods
Echocardiography was undergone in 833 patients with chronic liver disease during 2005–2019 and 13 patients (1.6%) were diagnosed with PoPH in this observational study. At the diagnosis of PoPH, liver function was evaluated by albumin–bilirubin (ALBI) score. Severe PoPH was defined as (1) mean pulmonary arterial pressure (mPAP) ≥50 mmHg or (2) mPAP: 35–49 mmHg and pulmonary vascular resistance ≥400 dyne/s/cm5. Factors associated with severe PoPH were evaluated by decision‐tree analysis.
Results
In patients with PoPH, the leading etiology of chronic liver disease was hepatitis C virus (HCV) (46.2% [sustained virological response (SVR): 23.1% and non‐SVR: 15.4%]). Severe PoPH was observed in 53.8% of patients and the 5‐year survival rate was 48.1%. There was a significant correlation of mPAP with ALBI score (r = 0.6456, p = 0.0171). In the decision‐tree and random forest analyses, the most impacted classifier for severe PoPH was the ALBI score. In patients with ALBI score ≥−1.45, all patients showed severe PoPH, while the prevalence of severe PoPH was 25.0% in patients with ALBI score <−1.45.
Conclusions
We found that HCV including SVR was the major etiology of chronic liver disease in patients with PoPH. Moreover, we revealed that the ALBI score was the most impacted factor associated with severe PoPH. Thus, ALBI score may be useful for the estimation of pulmonary vascular resistance.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/hepr.13714</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7064-4325</orcidid><orcidid>https://orcid.org/0000-0001-6098-1224</orcidid><orcidid>https://orcid.org/0000-0002-8947-109X</orcidid><orcidid>https://orcid.org/0000-0003-2011-8201</orcidid><orcidid>https://orcid.org/0000-0001-6571-9874</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Albumin Bilirubin Blood pressure Echocardiography Etiology Hepatitis C hepatitis C virus Hypertension Liver diseases portopulmonary hypertension prognosis |
| title | Association between the albumin–bilirubin (ALBI) score and severity of portopulmonary hypertension (PoPH): A data‐mining analysis |
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