Dopaminergic but not cholinergic neurodegeneration is correlated with gait disturbances in PINK1 knockout rats

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by gait dysfunction in later stages of the disease. PD hallmarks include a decrease in stride length, run speed, and swing time; an increase in stride time, stance time, and base of support; dopaminergic degeneration...

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Veröffentlicht in:	Behavioural brain research 2022-01, Vol.417, p.113575-113575, Article 113575
Hauptverfasser:	DeAngelo, VM, Hilliard, JD, McConnell, GC
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Corpus Striatum - metabolism Disease Models, Animal Dopamine Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Gait Disorders, Neurologic Gait disturbances Male Parkinson Disease - physiopathology Parkinson’s disease Pars Compacta - metabolism Pedunculopontine nucleus Phosphate buffered saline Protein Kinases PTEN-induced putative kinase 1 knockout Rats Substantia nigra pars compacta Tyrosine 3-Monooxygenase - metabolism Ventral tegmental area
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