Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems
The present paper aims at developing an integrated experimental/computational approach towards the design of shape memory devices fabricated by hot-processing with potential for use as gastroretentive drug delivery systems (DDSs) and for personalized therapy if 4D printing is involved. The approach...
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Veröffentlicht in: | Journal of the mechanical behavior of biomedical materials 2021-12, Vol.124, p.104814-104814, Article 104814 |
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container_title | Journal of the mechanical behavior of biomedical materials |
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creator | Inverardi, N. Scalet, G. Melocchi, A. Uboldi, M. Maroni, A. Zema, L. Gazzaniga, A. Auricchio, F. Briatico-Vangosa, F. Baldi, F. Pandini, S. |
description | The present paper aims at developing an integrated experimental/computational approach towards the design of shape memory devices fabricated by hot-processing with potential for use as gastroretentive drug delivery systems (DDSs) and for personalized therapy if 4D printing is involved. The approach was tested on a plasticized poly(vinyl alcohol) (PVA) of pharmaceutical grade, with a glass transition temperature close to that of the human body (i.e., 37 °C).
A comprehensive experimental analysis was conducted in order to fully characterize the PVA thermo-mechanical response as well as to provide the necessary data to calibrate and validate the numerical predictions, based on a thermo-viscoelastic constitutive model, implemented within a finite element framework. Particularly, a thorough thermal, mechanical, and shape memory characterization under different testing conditions and on different sample geometries was first performed. Then, a prototype consisting of an S-shaped device was fabricated, deformed in a temporary compact configuration and tested. Simulation results were compared with the results obtained from shape memory experiments carried out on the prototype. The proposed approach provided useful results and recommendations for the design of PVA-based shape memory DDSs. |
doi_str_mv | 10.1016/j.jmbbm.2021.104814 |
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A comprehensive experimental analysis was conducted in order to fully characterize the PVA thermo-mechanical response as well as to provide the necessary data to calibrate and validate the numerical predictions, based on a thermo-viscoelastic constitutive model, implemented within a finite element framework. Particularly, a thorough thermal, mechanical, and shape memory characterization under different testing conditions and on different sample geometries was first performed. Then, a prototype consisting of an S-shaped device was fabricated, deformed in a temporary compact configuration and tested. Simulation results were compared with the results obtained from shape memory experiments carried out on the prototype. The proposed approach provided useful results and recommendations for the design of PVA-based shape memory DDSs.</description><identifier>ISSN: 1751-6161</identifier><identifier>EISSN: 1878-0180</identifier><identifier>DOI: 10.1016/j.jmbbm.2021.104814</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Constitutive modeling ; Drug delivery systems ; Expandable gastroretentive drug delivery systems ; poly(vinyl alcohol) ; Shape memory polymers</subject><ispartof>Journal of the mechanical behavior of biomedical materials, 2021-12, Vol.124, p.104814-104814, Article 104814</ispartof><rights>2021 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-28da5be28ea4446d3951d024c0fae145f91bca254d070b028ebdeb141b9132c43</citedby><cites>FETCH-LOGICAL-c381t-28da5be28ea4446d3951d024c0fae145f91bca254d070b028ebdeb141b9132c43</cites><orcidid>0000-0002-7088-1064 ; 0000-0001-7683-566X ; 0000-0003-2390-8495</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmbbm.2021.104814$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Inverardi, N.</creatorcontrib><creatorcontrib>Scalet, G.</creatorcontrib><creatorcontrib>Melocchi, A.</creatorcontrib><creatorcontrib>Uboldi, M.</creatorcontrib><creatorcontrib>Maroni, A.</creatorcontrib><creatorcontrib>Zema, L.</creatorcontrib><creatorcontrib>Gazzaniga, A.</creatorcontrib><creatorcontrib>Auricchio, F.</creatorcontrib><creatorcontrib>Briatico-Vangosa, F.</creatorcontrib><creatorcontrib>Baldi, F.</creatorcontrib><creatorcontrib>Pandini, S.</creatorcontrib><title>Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems</title><title>Journal of the mechanical behavior of biomedical materials</title><description>The present paper aims at developing an integrated experimental/computational approach towards the design of shape memory devices fabricated by hot-processing with potential for use as gastroretentive drug delivery systems (DDSs) and for personalized therapy if 4D printing is involved. The approach was tested on a plasticized poly(vinyl alcohol) (PVA) of pharmaceutical grade, with a glass transition temperature close to that of the human body (i.e., 37 °C).
A comprehensive experimental analysis was conducted in order to fully characterize the PVA thermo-mechanical response as well as to provide the necessary data to calibrate and validate the numerical predictions, based on a thermo-viscoelastic constitutive model, implemented within a finite element framework. Particularly, a thorough thermal, mechanical, and shape memory characterization under different testing conditions and on different sample geometries was first performed. Then, a prototype consisting of an S-shaped device was fabricated, deformed in a temporary compact configuration and tested. Simulation results were compared with the results obtained from shape memory experiments carried out on the prototype. The proposed approach provided useful results and recommendations for the design of PVA-based shape memory DDSs.</description><subject>Constitutive modeling</subject><subject>Drug delivery systems</subject><subject>Expandable gastroretentive drug delivery systems</subject><subject>poly(vinyl alcohol)</subject><subject>Shape memory polymers</subject><issn>1751-6161</issn><issn>1878-0180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UT2P1DAQjRBIHAe_gMYlTRbbcRJvQYFOx4F00jVQWxN7suuVHRvbWZG_wq_Fe0t91Xy990Yzr2k-MrpjlA2fT7uTnya_45Sz2hGSiVfNDZOjbCmT9HXNx561AxvY2-ZdzidKB0qlvGn-3v-JmKzHpYAjsBiig49rgWLD8twBt2WbSZgJkHiE5EHjWqwG1x4SGCT5CBGJRx_SRmJwm8dEIEZn0ZASSDkiMXhGF-JlzUXpALmkkLDU2p7rOK2HinE1rxp5ywV9ft-8mcFl_PA_3ja_vt3_vPvePj49_Lj7-tjqTrLScmmgn5BLBCHEYLp9zwzlQtMZkIl-3rNJA--FoSOdaMVNBicm2LRnHdeiu20-XXVjCr9XzEV5mzU6BwuGNSvej6Lbj3wYK7S7QnUKOSecVay_g7QpRtXFCXVSz06oixPq6kRlfbmysF5xtphU1hYXjcYm1EWZYF_k_wOsaJeH</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Inverardi, N.</creator><creator>Scalet, G.</creator><creator>Melocchi, A.</creator><creator>Uboldi, M.</creator><creator>Maroni, A.</creator><creator>Zema, L.</creator><creator>Gazzaniga, A.</creator><creator>Auricchio, F.</creator><creator>Briatico-Vangosa, F.</creator><creator>Baldi, F.</creator><creator>Pandini, S.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7088-1064</orcidid><orcidid>https://orcid.org/0000-0001-7683-566X</orcidid><orcidid>https://orcid.org/0000-0003-2390-8495</orcidid></search><sort><creationdate>202112</creationdate><title>Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems</title><author>Inverardi, N. ; Scalet, G. ; Melocchi, A. ; Uboldi, M. ; Maroni, A. ; Zema, L. ; Gazzaniga, A. ; Auricchio, F. ; Briatico-Vangosa, F. ; Baldi, F. ; Pandini, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-28da5be28ea4446d3951d024c0fae145f91bca254d070b028ebdeb141b9132c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Constitutive modeling</topic><topic>Drug delivery systems</topic><topic>Expandable gastroretentive drug delivery systems</topic><topic>poly(vinyl alcohol)</topic><topic>Shape memory polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inverardi, N.</creatorcontrib><creatorcontrib>Scalet, G.</creatorcontrib><creatorcontrib>Melocchi, A.</creatorcontrib><creatorcontrib>Uboldi, M.</creatorcontrib><creatorcontrib>Maroni, A.</creatorcontrib><creatorcontrib>Zema, L.</creatorcontrib><creatorcontrib>Gazzaniga, A.</creatorcontrib><creatorcontrib>Auricchio, F.</creatorcontrib><creatorcontrib>Briatico-Vangosa, F.</creatorcontrib><creatorcontrib>Baldi, F.</creatorcontrib><creatorcontrib>Pandini, S.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inverardi, N.</au><au>Scalet, G.</au><au>Melocchi, A.</au><au>Uboldi, M.</au><au>Maroni, A.</au><au>Zema, L.</au><au>Gazzaniga, A.</au><au>Auricchio, F.</au><au>Briatico-Vangosa, F.</au><au>Baldi, F.</au><au>Pandini, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems</atitle><jtitle>Journal of the mechanical behavior of biomedical materials</jtitle><date>2021-12</date><risdate>2021</risdate><volume>124</volume><spage>104814</spage><epage>104814</epage><pages>104814-104814</pages><artnum>104814</artnum><issn>1751-6161</issn><eissn>1878-0180</eissn><abstract>The present paper aims at developing an integrated experimental/computational approach towards the design of shape memory devices fabricated by hot-processing with potential for use as gastroretentive drug delivery systems (DDSs) and for personalized therapy if 4D printing is involved. The approach was tested on a plasticized poly(vinyl alcohol) (PVA) of pharmaceutical grade, with a glass transition temperature close to that of the human body (i.e., 37 °C).
A comprehensive experimental analysis was conducted in order to fully characterize the PVA thermo-mechanical response as well as to provide the necessary data to calibrate and validate the numerical predictions, based on a thermo-viscoelastic constitutive model, implemented within a finite element framework. Particularly, a thorough thermal, mechanical, and shape memory characterization under different testing conditions and on different sample geometries was first performed. Then, a prototype consisting of an S-shaped device was fabricated, deformed in a temporary compact configuration and tested. Simulation results were compared with the results obtained from shape memory experiments carried out on the prototype. The proposed approach provided useful results and recommendations for the design of PVA-based shape memory DDSs.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.jmbbm.2021.104814</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7088-1064</orcidid><orcidid>https://orcid.org/0000-0001-7683-566X</orcidid><orcidid>https://orcid.org/0000-0003-2390-8495</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Constitutive modeling Drug delivery systems Expandable gastroretentive drug delivery systems poly(vinyl alcohol) Shape memory polymers |
title | Experimental and computational analysis of a pharmaceutical-grade shape memory polymer applied to the development of gastroretentive drug delivery systems |
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