Gas chromatography-mass spectrometry (GM-MS) analysis and biological activities of the aerial part of Cleome amblyocarpa Barr. and Murb
Cleome amblyocarpa Barr. and Murb is a medicinal plant widespread in North Africa and widely used in Tunisia to treat diabetes and colic. The non-volatile (polyphenols, flavonoids, tannins, and flavonols) and volatile compounds (GC-MS) of C . amblyocarpa leaves and stems have been studied. The antio...
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| Veröffentlicht in: | Environmental science and pollution research international 2020-06, Vol.27 (18), p.22670-22679 |
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| creator | Khlifi, Aida Chrifa, Amal Ben Lamine, Jihen Ben Thouri, Amira Adouni, Khawla Flamini, Guido Oleszek, Wiesław Achour, Lotfi |
| description | Cleome amblyocarpa
Barr. and Murb is a medicinal plant widespread in North Africa and widely used in Tunisia to treat diabetes and colic. The non-volatile (polyphenols, flavonoids, tannins, and flavonols) and volatile compounds (GC-MS) of
C
.
amblyocarpa
leaves and stems have been studied. The antioxidant, antimicrobial, analgesic, and cytotoxic activities of hydroalcoholic extracts of
C
.
amblyocarpa
leaves and stems were also investigated. The major volatile components were β-caryophyllene (46.9%), eugenol (25.6%), ethyl 3-methylpentanoate (16.2%), 7-
epi
-silphiperfol-5-ene (11.0%), and α-copaene (7.0%). The antioxidant activity has been evaluated using various in vitro assays, such as DPPH free radical scavenging activity, iron-chelating capability, and ability to inhibit lipid peroxidation (TBARS). The antibacterial and antifungal effectiveness of leaves and stems parts of
Cleome amblyocarpa
were investigated by means of the disc diffusion and microdilution techniques. The in vitro cytotoxicity of the hydroalcoholic extract of
C
.
amblyocarpa
on A549 and H1299 lung adenocarcinoma cells was determined using the crystal violet assay. The acute toxicity of the extracts on Swiss albino mice at the doses of 3000, 1500, and 500 mg/kg body weight was evaluated. The analgesic effect of leaves and stems extract was also determined by means of the acetic acid induced writhing test. The results indicated that the leaves have higher phenols, and flavonoids contents and potential antioxidant, antimicrobial, and anticancer activities in comparison to stem. In addition, the aerial part of
C
.
amblyocarpa
did not cause signs of toxicity or death in animals at doses up to 3000 mg/kg and have a significant analgesic activity. |
| doi_str_mv | 10.1007/s11356-020-08764-7 |
| format | Article |
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Barr. and Murb is a medicinal plant widespread in North Africa and widely used in Tunisia to treat diabetes and colic. The non-volatile (polyphenols, flavonoids, tannins, and flavonols) and volatile compounds (GC-MS) of
C
.
amblyocarpa
leaves and stems have been studied. The antioxidant, antimicrobial, analgesic, and cytotoxic activities of hydroalcoholic extracts of
C
.
amblyocarpa
leaves and stems were also investigated. The major volatile components were β-caryophyllene (46.9%), eugenol (25.6%), ethyl 3-methylpentanoate (16.2%), 7-
epi
-silphiperfol-5-ene (11.0%), and α-copaene (7.0%). The antioxidant activity has been evaluated using various in vitro assays, such as DPPH free radical scavenging activity, iron-chelating capability, and ability to inhibit lipid peroxidation (TBARS). The antibacterial and antifungal effectiveness of leaves and stems parts of
Cleome amblyocarpa
were investigated by means of the disc diffusion and microdilution techniques. The in vitro cytotoxicity of the hydroalcoholic extract of
C
.
amblyocarpa
on A549 and H1299 lung adenocarcinoma cells was determined using the crystal violet assay. The acute toxicity of the extracts on Swiss albino mice at the doses of 3000, 1500, and 500 mg/kg body weight was evaluated. The analgesic effect of leaves and stems extract was also determined by means of the acetic acid induced writhing test. The results indicated that the leaves have higher phenols, and flavonoids contents and potential antioxidant, antimicrobial, and anticancer activities in comparison to stem. In addition, the aerial part of
C
.
amblyocarpa
did not cause signs of toxicity or death in animals at doses up to 3000 mg/kg and have a significant analgesic activity.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-020-08764-7</identifier><identifier>PMID: 32323234</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetic acid ; Acute toxicity ; Adenocarcinoma ; aerial parts ; albino ; analgesic effect ; Analgesics ; Anticancer properties ; Antifungal activity ; Antiinfectives and antibacterials ; antioxidant activity ; Antioxidants ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Body weight ; Caryophyllene ; Chelation ; Cleome ; Colic ; Cytotoxicity ; death ; diabetes ; Diabetes mellitus ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Eugenol ; Flavonoids ; Flavonols ; Free radicals ; Fungicides ; Gas chromatography ; gas chromatography-mass spectrometry ; gentian violet ; Herbal medicine ; Leaves ; Lipid peroxidation ; Lipids ; Lung cancer ; lungs ; Mass spectrometry ; Mass spectroscopy ; Medicinal plants ; Peroxidation ; Phenols ; Polyphenols ; Research Article ; Scavenging ; Stems ; Tannins ; Toxicity ; Tunisia ; Volatile compounds ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2020-06, Vol.27 (18), p.22670-22679</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-39cb9b97ec87888615694c34e940c6bb66e8105bceb7500132b4d7a9c62ae8b13</citedby><cites>FETCH-LOGICAL-c445t-39cb9b97ec87888615694c34e940c6bb66e8105bceb7500132b4d7a9c62ae8b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-020-08764-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-020-08764-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32323234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khlifi, Aida</creatorcontrib><creatorcontrib>Chrifa, Amal Ben</creatorcontrib><creatorcontrib>Lamine, Jihen Ben</creatorcontrib><creatorcontrib>Thouri, Amira</creatorcontrib><creatorcontrib>Adouni, Khawla</creatorcontrib><creatorcontrib>Flamini, Guido</creatorcontrib><creatorcontrib>Oleszek, Wiesław</creatorcontrib><creatorcontrib>Achour, Lotfi</creatorcontrib><title>Gas chromatography-mass spectrometry (GM-MS) analysis and biological activities of the aerial part of Cleome amblyocarpa Barr. and Murb</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Cleome amblyocarpa
Barr. and Murb is a medicinal plant widespread in North Africa and widely used in Tunisia to treat diabetes and colic. The non-volatile (polyphenols, flavonoids, tannins, and flavonols) and volatile compounds (GC-MS) of
C
.
amblyocarpa
leaves and stems have been studied. The antioxidant, antimicrobial, analgesic, and cytotoxic activities of hydroalcoholic extracts of
C
.
amblyocarpa
leaves and stems were also investigated. The major volatile components were β-caryophyllene (46.9%), eugenol (25.6%), ethyl 3-methylpentanoate (16.2%), 7-
epi
-silphiperfol-5-ene (11.0%), and α-copaene (7.0%). The antioxidant activity has been evaluated using various in vitro assays, such as DPPH free radical scavenging activity, iron-chelating capability, and ability to inhibit lipid peroxidation (TBARS). The antibacterial and antifungal effectiveness of leaves and stems parts of
Cleome amblyocarpa
were investigated by means of the disc diffusion and microdilution techniques. The in vitro cytotoxicity of the hydroalcoholic extract of
C
.
amblyocarpa
on A549 and H1299 lung adenocarcinoma cells was determined using the crystal violet assay. The acute toxicity of the extracts on Swiss albino mice at the doses of 3000, 1500, and 500 mg/kg body weight was evaluated. The analgesic effect of leaves and stems extract was also determined by means of the acetic acid induced writhing test. The results indicated that the leaves have higher phenols, and flavonoids contents and potential antioxidant, antimicrobial, and anticancer activities in comparison to stem. In addition, the aerial part of
C
.
amblyocarpa
did not cause signs of toxicity or death in animals at doses up to 3000 mg/kg and have a significant analgesic activity.</description><subject>Acetic acid</subject><subject>Acute toxicity</subject><subject>Adenocarcinoma</subject><subject>aerial parts</subject><subject>albino</subject><subject>analgesic effect</subject><subject>Analgesics</subject><subject>Anticancer properties</subject><subject>Antifungal activity</subject><subject>Antiinfectives and antibacterials</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Body weight</subject><subject>Caryophyllene</subject><subject>Chelation</subject><subject>Cleome</subject><subject>Colic</subject><subject>Cytotoxicity</subject><subject>death</subject><subject>diabetes</subject><subject>Diabetes mellitus</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Eugenol</subject><subject>Flavonoids</subject><subject>Flavonols</subject><subject>Free radicals</subject><subject>Fungicides</subject><subject>Gas chromatography</subject><subject>gas chromatography-mass spectrometry</subject><subject>gentian violet</subject><subject>Herbal medicine</subject><subject>Leaves</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Lung cancer</subject><subject>lungs</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Medicinal plants</subject><subject>Peroxidation</subject><subject>Phenols</subject><subject>Polyphenols</subject><subject>Research Article</subject><subject>Scavenging</subject><subject>Stems</subject><subject>Tannins</subject><subject>Toxicity</subject><subject>Tunisia</subject><subject>Volatile compounds</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc9uEzEQxi1ERUPhBTggS1zKwcX_1l4fISoBqREH4GyNHSdxtRsv9i7SPkFfGzcpIHEomsOMZn7zjTQfQq8YvWKU6neFMdEoQjkltNVKEv0ELZhitZDGPEULaqQkTEh5jp6Xcksrabh-hs4FP4ZcoLsVFOz3OfUwpl2GYT-THkrBZQh-rO0w5hlfrtZk_fUthgN0c4mlFhvsYurSLnroMPgx_oxjDAWnLR73AUPIsQ4GyON9a9mFKoWhd92cPOQB8AfI-eootJ6ye4HOttCV8PIhX6DvH6-_LT-Rmy-rz8v3N8RL2YxEGO-MMzr4Vrdtq1ijjPRCBiOpV84pFVpGG-eD0w2lTHAnNxqMVxxC65i4QJcn3SGnH1Moo-1j8aHr4BDSVCxvtBSyPkf9HxVG8qbVR_TNP-htmnJ9VqUk46rRSotK8RPlcyolh60dcuwhz5ZRe--oPTlqq0_26KjVden1g_Tk-rD5s_LbwgqIE1Dq6LAL-e_tR2R_AUp1qw0</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Khlifi, Aida</creator><creator>Chrifa, Amal Ben</creator><creator>Lamine, Jihen Ben</creator><creator>Thouri, Amira</creator><creator>Adouni, Khawla</creator><creator>Flamini, Guido</creator><creator>Oleszek, Wiesław</creator><creator>Achour, Lotfi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature 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chromatography-mass spectrometry (GM-MS) analysis and biological activities of the aerial part of Cleome amblyocarpa Barr. and Murb</title><author>Khlifi, Aida ; Chrifa, Amal Ben ; Lamine, Jihen Ben ; Thouri, Amira ; Adouni, Khawla ; Flamini, Guido ; Oleszek, Wiesław ; Achour, Lotfi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-39cb9b97ec87888615694c34e940c6bb66e8105bceb7500132b4d7a9c62ae8b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic acid</topic><topic>Acute toxicity</topic><topic>Adenocarcinoma</topic><topic>aerial parts</topic><topic>albino</topic><topic>analgesic effect</topic><topic>Analgesics</topic><topic>Anticancer properties</topic><topic>Antifungal activity</topic><topic>Antiinfectives and antibacterials</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Body weight</topic><topic>Caryophyllene</topic><topic>Chelation</topic><topic>Cleome</topic><topic>Colic</topic><topic>Cytotoxicity</topic><topic>death</topic><topic>diabetes</topic><topic>Diabetes mellitus</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Eugenol</topic><topic>Flavonoids</topic><topic>Flavonols</topic><topic>Free radicals</topic><topic>Fungicides</topic><topic>Gas chromatography</topic><topic>gas chromatography-mass spectrometry</topic><topic>gentian violet</topic><topic>Herbal medicine</topic><topic>Leaves</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Lung cancer</topic><topic>lungs</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Medicinal plants</topic><topic>Peroxidation</topic><topic>Phenols</topic><topic>Polyphenols</topic><topic>Research Article</topic><topic>Scavenging</topic><topic>Stems</topic><topic>Tannins</topic><topic>Toxicity</topic><topic>Tunisia</topic><topic>Volatile compounds</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khlifi, Aida</creatorcontrib><creatorcontrib>Chrifa, Amal Ben</creatorcontrib><creatorcontrib>Lamine, Jihen Ben</creatorcontrib><creatorcontrib>Thouri, Amira</creatorcontrib><creatorcontrib>Adouni, Khawla</creatorcontrib><creatorcontrib>Flamini, Guido</creatorcontrib><creatorcontrib>Oleszek, Wiesław</creatorcontrib><creatorcontrib>Achour, Lotfi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology 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Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khlifi, Aida</au><au>Chrifa, Amal Ben</au><au>Lamine, Jihen Ben</au><au>Thouri, Amira</au><au>Adouni, Khawla</au><au>Flamini, Guido</au><au>Oleszek, Wiesław</au><au>Achour, Lotfi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gas chromatography-mass spectrometry (GM-MS) analysis and biological activities of the aerial part of Cleome amblyocarpa Barr. and Murb</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>27</volume><issue>18</issue><spage>22670</spage><epage>22679</epage><pages>22670-22679</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Cleome amblyocarpa
Barr. and Murb is a medicinal plant widespread in North Africa and widely used in Tunisia to treat diabetes and colic. The non-volatile (polyphenols, flavonoids, tannins, and flavonols) and volatile compounds (GC-MS) of
C
.
amblyocarpa
leaves and stems have been studied. The antioxidant, antimicrobial, analgesic, and cytotoxic activities of hydroalcoholic extracts of
C
.
amblyocarpa
leaves and stems were also investigated. The major volatile components were β-caryophyllene (46.9%), eugenol (25.6%), ethyl 3-methylpentanoate (16.2%), 7-
epi
-silphiperfol-5-ene (11.0%), and α-copaene (7.0%). The antioxidant activity has been evaluated using various in vitro assays, such as DPPH free radical scavenging activity, iron-chelating capability, and ability to inhibit lipid peroxidation (TBARS). The antibacterial and antifungal effectiveness of leaves and stems parts of
Cleome amblyocarpa
were investigated by means of the disc diffusion and microdilution techniques. The in vitro cytotoxicity of the hydroalcoholic extract of
C
.
amblyocarpa
on A549 and H1299 lung adenocarcinoma cells was determined using the crystal violet assay. The acute toxicity of the extracts on Swiss albino mice at the doses of 3000, 1500, and 500 mg/kg body weight was evaluated. The analgesic effect of leaves and stems extract was also determined by means of the acetic acid induced writhing test. The results indicated that the leaves have higher phenols, and flavonoids contents and potential antioxidant, antimicrobial, and anticancer activities in comparison to stem. In addition, the aerial part of
C
.
amblyocarpa
did not cause signs of toxicity or death in animals at doses up to 3000 mg/kg and have a significant analgesic activity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32323234</pmid><doi>10.1007/s11356-020-08764-7</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2020-06, Vol.27 (18), p.22670-22679 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2574342326 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Acetic acid Acute toxicity Adenocarcinoma aerial parts albino analgesic effect Analgesics Anticancer properties Antifungal activity Antiinfectives and antibacterials antioxidant activity Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Body weight Caryophyllene Chelation Cleome Colic Cytotoxicity death diabetes Diabetes mellitus Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Eugenol Flavonoids Flavonols Free radicals Fungicides Gas chromatography gas chromatography-mass spectrometry gentian violet Herbal medicine Leaves Lipid peroxidation Lipids Lung cancer lungs Mass spectrometry Mass spectroscopy Medicinal plants Peroxidation Phenols Polyphenols Research Article Scavenging Stems Tannins Toxicity Tunisia Volatile compounds Waste Water Technology Water Management Water Pollution Control |
| title | Gas chromatography-mass spectrometry (GM-MS) analysis and biological activities of the aerial part of Cleome amblyocarpa Barr. and Murb |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T07%3A00%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gas%20chromatography-mass%20spectrometry%20(GM-MS)%20analysis%20and%20biological%20activities%20of%20the%20aerial%20part%20of%20Cleome%20amblyocarpa%20Barr.%20and%20Murb&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Khlifi,%20Aida&rft.date=2020-06-01&rft.volume=27&rft.issue=18&rft.spage=22670&rft.epage=22679&rft.pages=22670-22679&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-020-08764-7&rft_dat=%3Cproquest_cross%3E2394258726%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2412657673&rft_id=info:pmid/32323234&rfr_iscdi=true |