Myrtle (Myrtus communis) leaf extract suppresses hepatotoxicity induced by monosodium glutamate and acrylamide through obstructing apoptosis, DNA fragmentation, and cell cycle arrest
A large number of plant extracts have demonstrated to provide health benefits and mitigate several disease conditions. However, at the molecular and cellular levels, few studies have been conducted. The present work was designed to study the effect of Myrtus communis leaf extract (ME) (300 mg/kg bw)...
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| Veröffentlicht in: | Environmental science and pollution research international 2020-06, Vol.27 (18), p.23188-23198 |
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| creator | Hassan, Hanaa A. EL-Kholy, Wafaa M. EL-Sawi, Mamdouh R. F. Galal, Nadine A. Ramadan, Mohamed Fawzy |
| description | A large number of plant extracts have demonstrated to provide health benefits and mitigate several disease conditions. However, at the molecular and cellular levels, few studies have been conducted. The present work was designed to study the effect of
Myrtus communis
leaf extract (ME) (300 mg/kg bw) against hepatotoxicity induced by monosodium glutamate (MSG) (100 mg/kg bw), and acrylamide (ACR) (20 mg/kg bw) in male rats and determining its molecular and cellular mechanisms. The data showed that the treatment with MSG and/or ACR induced significant changes in numerous biomarkers (Bcl-2 and the programmed cell death protein-1) related to liver damage, as recorded by genotoxicity, apoptosis, and histopathological changes. On the other side, the oral administration of ME (300 mg/kg bw) improved the hepatic conditions as confirmed by the improvement in cell viability, programmed cell death, and histopathological alterations. It can be concluded that the consumption of ME might be useful for minimizing the occurred hepatotoxicity through up-regulation of the key apoptotic regulators as well as the improvement of DNA content and cell cycle restoration.
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| doi_str_mv | 10.1007/s11356-020-08780-7 |
| format | Article |
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Myrtus communis
leaf extract (ME) (300 mg/kg bw) against hepatotoxicity induced by monosodium glutamate (MSG) (100 mg/kg bw), and acrylamide (ACR) (20 mg/kg bw) in male rats and determining its molecular and cellular mechanisms. The data showed that the treatment with MSG and/or ACR induced significant changes in numerous biomarkers (Bcl-2 and the programmed cell death protein-1) related to liver damage, as recorded by genotoxicity, apoptosis, and histopathological changes. On the other side, the oral administration of ME (300 mg/kg bw) improved the hepatic conditions as confirmed by the improvement in cell viability, programmed cell death, and histopathological alterations. It can be concluded that the consumption of ME might be useful for minimizing the occurred hepatotoxicity through up-regulation of the key apoptotic regulators as well as the improvement of DNA content and cell cycle restoration.
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Myrtus communis
leaf extract (ME) (300 mg/kg bw) against hepatotoxicity induced by monosodium glutamate (MSG) (100 mg/kg bw), and acrylamide (ACR) (20 mg/kg bw) in male rats and determining its molecular and cellular mechanisms. The data showed that the treatment with MSG and/or ACR induced significant changes in numerous biomarkers (Bcl-2 and the programmed cell death protein-1) related to liver damage, as recorded by genotoxicity, apoptosis, and histopathological changes. On the other side, the oral administration of ME (300 mg/kg bw) improved the hepatic conditions as confirmed by the improvement in cell viability, programmed cell death, and histopathological alterations. It can be concluded that the consumption of ME might be useful for minimizing the occurred hepatotoxicity through up-regulation of the key apoptotic regulators as well as the improvement of DNA content and cell cycle restoration.
Graphical abstract</description><subject>Acrylamide</subject><subject>acrylamides</subject><subject>Apoptosis</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bcl-2 protein</subject><subject>Biomarkers</subject><subject>Blocking</subject><subject>Cell cycle</subject><subject>cell cycle checkpoints</subject><subject>Cell death</subject><subject>Cell viability</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA fragmentation</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Genotoxicity</subject><subject>Hepatotoxicity</subject><subject>histopathology</subject><subject>leaf extracts</subject><subject>Leaves</subject><subject>liver</subject><subject>males</subject><subject>Monosodium glutamate</subject><subject>Myrtus communis</subject><subject>Oral administration</subject><subject>Plant extracts</subject><subject>Regulators</subject><subject>Research Article</subject><subject>Restoration</subject><subject>Sodium glutamate</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc1u1TAQhS0EopfCC7BAltgUqQE7tuN4WRUoSAU23VuO7eS6iuPgH6l5sT4fvr0FJBbMZjSab84c6QDwGqP3GCH-IWFMWNegFjWo5z1q-BOwwx2mDadCPAU7JChtMKH0BLxI6RZVUrT8OTghLanF2A7cf9tini08O_SSoA7el8Wld3C2aoT2LkelM0xlXaNNySa4t6vKIYc7p13eoFtM0dbAYYM-LCEF44qH01yy8ipbqBYDlY7brLwzFuZ9DGXawzCkHIvObpmgWsOaQ3LpHH78fgHHqCZvl6yyC8v5g4C28wz1pqtRFauP_BI8G9Wc7KvHfgpuPn-6ufzSXP-4-np5cd1oSlluMEN20K0WgyGI1KkzvRksY53gY49ao0g3Uk0tZYIzMwjbib4dmaJ6oONITsHZUXaN4Wepf6V36WBGLTaUJFvGKSEci66ib_9Bb0OJSzUnW4rbjnHR0Uq1R0rHkFK0o1yj8ypuEiN5CFUeQ5U1KvkQquT16M2jdBm8NX9OfqdYAXIEUl0tk41_f_9H9hfEmrHA</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Hassan, Hanaa A.</creator><creator>EL-Kholy, Wafaa M.</creator><creator>EL-Sawi, Mamdouh R. 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F.</au><au>Galal, Nadine A.</au><au>Ramadan, Mohamed Fawzy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myrtle (Myrtus communis) leaf extract suppresses hepatotoxicity induced by monosodium glutamate and acrylamide through obstructing apoptosis, DNA fragmentation, and cell cycle arrest</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>27</volume><issue>18</issue><spage>23188</spage><epage>23198</epage><pages>23188-23198</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>A large number of plant extracts have demonstrated to provide health benefits and mitigate several disease conditions. However, at the molecular and cellular levels, few studies have been conducted. The present work was designed to study the effect of
Myrtus communis
leaf extract (ME) (300 mg/kg bw) against hepatotoxicity induced by monosodium glutamate (MSG) (100 mg/kg bw), and acrylamide (ACR) (20 mg/kg bw) in male rats and determining its molecular and cellular mechanisms. The data showed that the treatment with MSG and/or ACR induced significant changes in numerous biomarkers (Bcl-2 and the programmed cell death protein-1) related to liver damage, as recorded by genotoxicity, apoptosis, and histopathological changes. On the other side, the oral administration of ME (300 mg/kg bw) improved the hepatic conditions as confirmed by the improvement in cell viability, programmed cell death, and histopathological alterations. It can be concluded that the consumption of ME might be useful for minimizing the occurred hepatotoxicity through up-regulation of the key apoptotic regulators as well as the improvement of DNA content and cell cycle restoration.
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| ispartof | Environmental science and pollution research international, 2020-06, Vol.27 (18), p.23188-23198 |
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| subjects | Acrylamide acrylamides Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bcl-2 protein Biomarkers Blocking Cell cycle cell cycle checkpoints Cell death Cell viability Deoxyribonucleic acid DNA DNA fragmentation Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Genotoxicity Hepatotoxicity histopathology leaf extracts Leaves liver males Monosodium glutamate Myrtus communis Oral administration Plant extracts Regulators Research Article Restoration Sodium glutamate Waste Water Technology Water Management Water Pollution Control |
| title | Myrtle (Myrtus communis) leaf extract suppresses hepatotoxicity induced by monosodium glutamate and acrylamide through obstructing apoptosis, DNA fragmentation, and cell cycle arrest |
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