The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study
Though evidence exists on the association between diazinon (DZN), an organophosphate pesticide, with hyperglycemia, contrasting reports also exist. Herein, we performed a systematic and meta-analysis study to address this issue. A systematic search was conducted in PubMed, Ovid Medline, Google Schol...
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| Veröffentlicht in: | Environmental science and pollution research international 2021, Vol.28 (4), p.4007-4018 |
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| creator | Farkhondeh, Tahereh Aschner, Michael Sadeghi, Mahmood Mehrpour, Omid Naseri, Kobra Amirabadizadeh, Alireza Roshanravan, Babak Aramjoo, Hamed Samarghandian, Saeed |
| description | Though evidence exists on the association between diazinon (DZN), an organophosphate pesticide, with hyperglycemia, contrasting reports also exist. Herein, we performed a systematic and meta-analysis study to address this issue. A systematic search was conducted in PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science up to April 5, 2020, searching for animal studies (rodents and fish) that assessed the impact of DZN on blood glucose concentration. The risk of bias was assessed by the SYRCLE’s RoB scale. Once each article’s quality was assessed, a random-effects meta-regression was used to pool the data into a meta-analysis. Heterogeneity between the studies was evaluated with the
I
square and
Q
test. Random-effect meta-analysis of 19 studies (
I
2
= 90.5%,
p
< 0.001) indicated low heterogeneity between the studies. DZN significantly increased blood glucose levels in the exposed versus control groups (95% CI: 2.46–4.94;
Z
= 5.86;
p
< 0.001). Subgroup analysis indicated that the effect of high-dose (3.40 (95% CI: 2.03–4.76)) DZN on changes in blood glucose was more pronounced than in the low dose (4.83 (95% CI: 1.56–8.11)). It was also ascertained that the blood glucose level was significantly higher in females (3.55 (95% CI: 2.21–4.89)) versus males (4.87 (95% CI: 0.20–9.55)) exposed to DZN. No publication bias was observed. Sensitivity analysis showed the robustness of the (standardized mean differences: 3.26–4.03). Our findings establish an association between DZN exposure and hyperglycemia in rodents and fish, which is both dose- and gender-dependent. |
| doi_str_mv | 10.1007/s11356-020-11364-0 |
| format | Article |
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I
square and
Q
test. Random-effect meta-analysis of 19 studies (
I
2
= 90.5%,
p
< 0.001) indicated low heterogeneity between the studies. DZN significantly increased blood glucose levels in the exposed versus control groups (95% CI: 2.46–4.94;
Z
= 5.86;
p
< 0.001). Subgroup analysis indicated that the effect of high-dose (3.40 (95% CI: 2.03–4.76)) DZN on changes in blood glucose was more pronounced than in the low dose (4.83 (95% CI: 1.56–8.11)). It was also ascertained that the blood glucose level was significantly higher in females (3.55 (95% CI: 2.21–4.89)) versus males (4.87 (95% CI: 0.20–9.55)) exposed to DZN. No publication bias was observed. Sensitivity analysis showed the robustness of the (standardized mean differences: 3.26–4.03). Our findings establish an association between DZN exposure and hyperglycemia in rodents and fish, which is both dose- and gender-dependent.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-020-11364-0</identifier><identifier>PMID: 33175357</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bias ; Blood ; Blood Glucose ; Blood levels ; Diazinon ; Diazinon - toxicity ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Exposure ; Female ; Fish ; Fungicides ; Glucose ; Heterogeneity ; Homeostasis ; Hyperglycemia ; Insecticides ; Insecticides - toxicity ; Male ; Meta-analysis ; Organophosphates ; Organophosphorus pesticides ; Pesticides ; Quality assessment ; Regression analysis ; Review Article ; risk ; Rodents ; Search engines ; Sensitivity analysis ; Subgroups ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2021, Vol.28 (4), p.4007-4018</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-133f0be418a558d48c35a72d72872632c6083e13432f0c4e15391378341b625c3</citedby><cites>FETCH-LOGICAL-c466t-133f0be418a558d48c35a72d72872632c6083e13432f0c4e15391378341b625c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-020-11364-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-020-11364-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33175357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farkhondeh, Tahereh</creatorcontrib><creatorcontrib>Aschner, Michael</creatorcontrib><creatorcontrib>Sadeghi, Mahmood</creatorcontrib><creatorcontrib>Mehrpour, Omid</creatorcontrib><creatorcontrib>Naseri, Kobra</creatorcontrib><creatorcontrib>Amirabadizadeh, Alireza</creatorcontrib><creatorcontrib>Roshanravan, Babak</creatorcontrib><creatorcontrib>Aramjoo, Hamed</creatorcontrib><creatorcontrib>Samarghandian, Saeed</creatorcontrib><title>The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Though evidence exists on the association between diazinon (DZN), an organophosphate pesticide, with hyperglycemia, contrasting reports also exist. Herein, we performed a systematic and meta-analysis study to address this issue. A systematic search was conducted in PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science up to April 5, 2020, searching for animal studies (rodents and fish) that assessed the impact of DZN on blood glucose concentration. The risk of bias was assessed by the SYRCLE’s RoB scale. Once each article’s quality was assessed, a random-effects meta-regression was used to pool the data into a meta-analysis. Heterogeneity between the studies was evaluated with the
I
square and
Q
test. Random-effect meta-analysis of 19 studies (
I
2
= 90.5%,
p
< 0.001) indicated low heterogeneity between the studies. DZN significantly increased blood glucose levels in the exposed versus control groups (95% CI: 2.46–4.94;
Z
= 5.86;
p
< 0.001). Subgroup analysis indicated that the effect of high-dose (3.40 (95% CI: 2.03–4.76)) DZN on changes in blood glucose was more pronounced than in the low dose (4.83 (95% CI: 1.56–8.11)). It was also ascertained that the blood glucose level was significantly higher in females (3.55 (95% CI: 2.21–4.89)) versus males (4.87 (95% CI: 0.20–9.55)) exposed to DZN. No publication bias was observed. Sensitivity analysis showed the robustness of the (standardized mean differences: 3.26–4.03). Our findings establish an association between DZN exposure and hyperglycemia in rodents and fish, which is both dose- and gender-dependent.</description><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bias</subject><subject>Blood</subject><subject>Blood Glucose</subject><subject>Blood levels</subject><subject>Diazinon</subject><subject>Diazinon - toxicity</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Exposure</subject><subject>Female</subject><subject>Fish</subject><subject>Fungicides</subject><subject>Glucose</subject><subject>Heterogeneity</subject><subject>Homeostasis</subject><subject>Hyperglycemia</subject><subject>Insecticides</subject><subject>Insecticides - toxicity</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Organophosphates</subject><subject>Organophosphorus pesticides</subject><subject>Pesticides</subject><subject>Quality assessment</subject><subject>Regression analysis</subject><subject>Review Article</subject><subject>risk</subject><subject>Rodents</subject><subject>Search engines</subject><subject>Sensitivity analysis</subject><subject>Subgroups</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-AQ-y4MVLdD-ziTcpfoHgpR48LdvNpE1JsjWTHOqvd7VVwYOwMAvzvO_MvISccnbJGTNXyLnUacIES-IvVQnbI2OecpUYlef7ZMxypRIulRqRI8QVi2QuzCEZScmNltqMyetsCRTKEnxPQ0mLyr1XbWhpfPM6hIIu6sEHBLoMDQTsHVZ4TR3FDfbQuL7y1LUFbaB3iWtdvYl9iv1QbI7JQelqhJNdnZCXu9vZ9CF5er5_nN48JV6laR_XkyWbg-KZ0zorVOaldkYURmRGpFL4lGUS4hFSlMwr4FrmXJpMKj5PhfZyQi62vusuvA2AvW0q9FDXroUwoBXaRK3OuYno-R90FYYubh0plTGtDM_ySIkt5buA2EFp113VuG5jObOfwdtt8DbGab-CtyyKznbWw7yB4kfynXQE5BbA2GoX0P3O_sf2Ax3Ei78</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Farkhondeh, Tahereh</creator><creator>Aschner, Michael</creator><creator>Sadeghi, Mahmood</creator><creator>Mehrpour, Omid</creator><creator>Naseri, Kobra</creator><creator>Amirabadizadeh, Alireza</creator><creator>Roshanravan, Babak</creator><creator>Aramjoo, Hamed</creator><creator>Samarghandian, Saeed</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>2021</creationdate><title>The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study</title><author>Farkhondeh, Tahereh ; Aschner, Michael ; Sadeghi, Mahmood ; Mehrpour, Omid ; Naseri, Kobra ; Amirabadizadeh, Alireza ; Roshanravan, Babak ; Aramjoo, Hamed ; Samarghandian, Saeed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-133f0be418a558d48c35a72d72872632c6083e13432f0c4e15391378341b625c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bias</topic><topic>Blood</topic><topic>Blood Glucose</topic><topic>Blood levels</topic><topic>Diazinon</topic><topic>Diazinon - 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Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farkhondeh, Tahereh</au><au>Aschner, Michael</au><au>Sadeghi, Mahmood</au><au>Mehrpour, Omid</au><au>Naseri, Kobra</au><au>Amirabadizadeh, Alireza</au><au>Roshanravan, Babak</au><au>Aramjoo, Hamed</au><au>Samarghandian, Saeed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>28</volume><issue>4</issue><spage>4007</spage><epage>4018</epage><pages>4007-4018</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Though evidence exists on the association between diazinon (DZN), an organophosphate pesticide, with hyperglycemia, contrasting reports also exist. Herein, we performed a systematic and meta-analysis study to address this issue. A systematic search was conducted in PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science up to April 5, 2020, searching for animal studies (rodents and fish) that assessed the impact of DZN on blood glucose concentration. The risk of bias was assessed by the SYRCLE’s RoB scale. Once each article’s quality was assessed, a random-effects meta-regression was used to pool the data into a meta-analysis. Heterogeneity between the studies was evaluated with the
I
square and
Q
test. Random-effect meta-analysis of 19 studies (
I
2
= 90.5%,
p
< 0.001) indicated low heterogeneity between the studies. DZN significantly increased blood glucose levels in the exposed versus control groups (95% CI: 2.46–4.94;
Z
= 5.86;
p
< 0.001). Subgroup analysis indicated that the effect of high-dose (3.40 (95% CI: 2.03–4.76)) DZN on changes in blood glucose was more pronounced than in the low dose (4.83 (95% CI: 1.56–8.11)). It was also ascertained that the blood glucose level was significantly higher in females (3.55 (95% CI: 2.21–4.89)) versus males (4.87 (95% CI: 0.20–9.55)) exposed to DZN. No publication bias was observed. Sensitivity analysis showed the robustness of the (standardized mean differences: 3.26–4.03). Our findings establish an association between DZN exposure and hyperglycemia in rodents and fish, which is both dose- and gender-dependent.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33175357</pmid><doi>10.1007/s11356-020-11364-0</doi><tpages>12</tpages></addata></record> |
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| ispartof | Environmental science and pollution research international, 2021, Vol.28 (4), p.4007-4018 |
| issn | 0944-1344 1614-7499 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bias Blood Blood Glucose Blood levels Diazinon Diazinon - toxicity Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Exposure Female Fish Fungicides Glucose Heterogeneity Homeostasis Hyperglycemia Insecticides Insecticides - toxicity Male Meta-analysis Organophosphates Organophosphorus pesticides Pesticides Quality assessment Regression analysis Review Article risk Rodents Search engines Sensitivity analysis Subgroups Waste Water Technology Water Management Water Pollution Control |
| title | The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study |
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