The relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan
This follow-up study was conducted over 30 years in a cadmium-polluted area of Japan. Urinary cadmium (U-Cd) concentration decreased by nearly half from 1986 to 2008 in men and women. However, it increased from 2008 to 2014 and maintained similar levels in 2016. Because renal atrophy may induce an i...
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| Veröffentlicht in: | Environmental science and pollution research international 2021-05, Vol.28 (18), p.22372-22379 |
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| creator | Sun, Xian Liang Kido, Teruhiko Nakagawa, Hideaki Nishijo, Muneko Sakurai, Masaru Ishizaki, Masao Morikawa, Yuko Okamoto, Rie Ichimori, Akie Ohno, Naoki Kobayashi, Satoshi Miyati, Toshiaki Nogawa, Kazuhiro Suwazono, Yasushi |
| description | This follow-up study was conducted over 30 years in a cadmium-polluted area of Japan. Urinary cadmium (U-Cd) concentration decreased by nearly half from 1986 to 2008 in men and women. However, it increased from 2008 to 2014 and maintained similar levels in 2016. Because renal atrophy may induce an increase in U-Cd, kidney volumes were determined using magnetic resonance imaging (MRI) scans in 2018. Based on the MRI results, we divided the participants into two groups, namely the normal group (
n
= 6, three men and three women) and the lesion group (
n
= 6, three men and three women). The level of urinary N-acetyl-β-d-glucosaminidase/creatinine (U-NAG/Cr) in the lesion group was significantly higher than in the normal group. The level of serum alkaline phosphatase (Al-P) was positively associated with U-Cd. Age and renal cortex volumes showed significantly negative associations. However, U-Cd and renal cortex and kidney volumes showed no significant associations. These results suggest that U-NAG and serum Al-P were sensitive biomarkers to reflect renal tubular dysfunction and bone damage caused by cadmium poisoning. Individuals chronically exposed to Cd should be observed carefully, due to the increased effect of aging on renal cortex volumes. |
| doi_str_mv | 10.1007/s11356-020-12278-7 |
| format | Article |
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n
= 6, three men and three women) and the lesion group (
n
= 6, three men and three women). The level of urinary N-acetyl-β-d-glucosaminidase/creatinine (U-NAG/Cr) in the lesion group was significantly higher than in the normal group. The level of serum alkaline phosphatase (Al-P) was positively associated with U-Cd. Age and renal cortex volumes showed significantly negative associations. However, U-Cd and renal cortex and kidney volumes showed no significant associations. These results suggest that U-NAG and serum Al-P were sensitive biomarkers to reflect renal tubular dysfunction and bone damage caused by cadmium poisoning. Individuals chronically exposed to Cd should be observed carefully, due to the increased effect of aging on renal cortex volumes.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-020-12278-7</identifier><identifier>PMID: 33420688</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acetylglucosaminidase ; Aging ; Alkaline phosphatase ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Atrophy ; beta 2-Microglobulin ; Biomarkers ; blood serum ; Cadmium ; Cadmium - analysis ; cortex ; Creatinine ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Exposure - analysis ; Environmental Health ; Environmental science ; Female ; Follow-Up Studies ; Glucosaminidase ; Humans ; Japan ; Kidney - chemistry ; Kidneys ; Lesions ; Magnetic resonance imaging ; magnetism ; Male ; Neuroimaging ; Renal cortex ; Renal function ; Research Article ; Waste Water Technology ; Water Management ; Water Pollution Control ; Women</subject><ispartof>Environmental science and pollution research international, 2021-05, Vol.28 (18), p.22372-22379</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-d5d96df6d746d9bbd57bdf55a4aff56262715bb31b07ab1602bc21c91e6ae0ec3</citedby><cites>FETCH-LOGICAL-c445t-d5d96df6d746d9bbd57bdf55a4aff56262715bb31b07ab1602bc21c91e6ae0ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-020-12278-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-020-12278-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33420688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Xian Liang</creatorcontrib><creatorcontrib>Kido, Teruhiko</creatorcontrib><creatorcontrib>Nakagawa, Hideaki</creatorcontrib><creatorcontrib>Nishijo, Muneko</creatorcontrib><creatorcontrib>Sakurai, Masaru</creatorcontrib><creatorcontrib>Ishizaki, Masao</creatorcontrib><creatorcontrib>Morikawa, Yuko</creatorcontrib><creatorcontrib>Okamoto, Rie</creatorcontrib><creatorcontrib>Ichimori, Akie</creatorcontrib><creatorcontrib>Ohno, Naoki</creatorcontrib><creatorcontrib>Kobayashi, Satoshi</creatorcontrib><creatorcontrib>Miyati, Toshiaki</creatorcontrib><creatorcontrib>Nogawa, Kazuhiro</creatorcontrib><creatorcontrib>Suwazono, Yasushi</creatorcontrib><title>The relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>This follow-up study was conducted over 30 years in a cadmium-polluted area of Japan. Urinary cadmium (U-Cd) concentration decreased by nearly half from 1986 to 2008 in men and women. However, it increased from 2008 to 2014 and maintained similar levels in 2016. Because renal atrophy may induce an increase in U-Cd, kidney volumes were determined using magnetic resonance imaging (MRI) scans in 2018. Based on the MRI results, we divided the participants into two groups, namely the normal group (
n
= 6, three men and three women) and the lesion group (
n
= 6, three men and three women). The level of urinary N-acetyl-β-d-glucosaminidase/creatinine (U-NAG/Cr) in the lesion group was significantly higher than in the normal group. The level of serum alkaline phosphatase (Al-P) was positively associated with U-Cd. Age and renal cortex volumes showed significantly negative associations. However, U-Cd and renal cortex and kidney volumes showed no significant associations. These results suggest that U-NAG and serum Al-P were sensitive biomarkers to reflect renal tubular dysfunction and bone damage caused by cadmium poisoning. Individuals chronically exposed to Cd should be observed carefully, due to the increased effect of aging on renal cortex volumes.</description><subject>Acetylglucosaminidase</subject><subject>Aging</subject><subject>Alkaline phosphatase</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Atrophy</subject><subject>beta 2-Microglobulin</subject><subject>Biomarkers</subject><subject>blood serum</subject><subject>Cadmium</subject><subject>Cadmium - analysis</subject><subject>cortex</subject><subject>Creatinine</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucosaminidase</subject><subject>Humans</subject><subject>Japan</subject><subject>Kidney - chemistry</subject><subject>Kidneys</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>magnetism</subject><subject>Male</subject><subject>Neuroimaging</subject><subject>Renal cortex</subject><subject>Renal function</subject><subject>Research Article</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Women</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtv1TAQhS1ERW9b_gALZIkNG1Pb8SNZooqnKrFp19Y4nnBTJXawEwr_Hl9uCxILZEtezHfOyOcQ8kLwN4Jze1mEaLRhXHImpLQts0_IThihmFVd95TseKcUE41Sp-SslDteyU7aZ-S0aZTkpm13ZL7ZI804wTqmWPbjQj2u94iR9hDmcZsp_lhS2TJSiKGSESb6PU3bjHSM9e7BjyvEtdA0UHhUsSVN07ZioJARDqPPsEC8ICcDTAWfP7zn5Pb9u5urj-z6y4dPV2-vWa-UXlnQoTNhMMEqEzrvg7Y-DFqDgmHQRhpphfa-EZ5b8MJw6Xsp-k6gAeTYN-fk9dF3yenbhmV181h6nCaImLbipLaqEbZreUVf_YPepS3XXx6oemqutq2UPFJ9TqVkHNySxxnyTye4O5ThjmW4GrH7XYazVfTywXrzM4Y_ksf0K9AcgVJH8Svmv7v_Y_sLZ5GV5g</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Sun, Xian Liang</creator><creator>Kido, Teruhiko</creator><creator>Nakagawa, Hideaki</creator><creator>Nishijo, Muneko</creator><creator>Sakurai, Masaru</creator><creator>Ishizaki, 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relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan</title><author>Sun, Xian Liang ; Kido, Teruhiko ; Nakagawa, Hideaki ; Nishijo, Muneko ; Sakurai, Masaru ; Ishizaki, Masao ; Morikawa, Yuko ; Okamoto, Rie ; Ichimori, Akie ; Ohno, Naoki ; Kobayashi, Satoshi ; Miyati, Toshiaki ; Nogawa, Kazuhiro ; Suwazono, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-d5d96df6d746d9bbd57bdf55a4aff56262715bb31b07ab1602bc21c91e6ae0ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetylglucosaminidase</topic><topic>Aging</topic><topic>Alkaline phosphatase</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Atrophy</topic><topic>beta 2-Microglobulin</topic><topic>Biomarkers</topic><topic>blood serum</topic><topic>Cadmium</topic><topic>Cadmium - 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Sci Pollut Res Int</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>28</volume><issue>18</issue><spage>22372</spage><epage>22379</epage><pages>22372-22379</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>This follow-up study was conducted over 30 years in a cadmium-polluted area of Japan. Urinary cadmium (U-Cd) concentration decreased by nearly half from 1986 to 2008 in men and women. However, it increased from 2008 to 2014 and maintained similar levels in 2016. Because renal atrophy may induce an increase in U-Cd, kidney volumes were determined using magnetic resonance imaging (MRI) scans in 2018. Based on the MRI results, we divided the participants into two groups, namely the normal group (
n
= 6, three men and three women) and the lesion group (
n
= 6, three men and three women). The level of urinary N-acetyl-β-d-glucosaminidase/creatinine (U-NAG/Cr) in the lesion group was significantly higher than in the normal group. The level of serum alkaline phosphatase (Al-P) was positively associated with U-Cd. Age and renal cortex volumes showed significantly negative associations. However, U-Cd and renal cortex and kidney volumes showed no significant associations. These results suggest that U-NAG and serum Al-P were sensitive biomarkers to reflect renal tubular dysfunction and bone damage caused by cadmium poisoning. Individuals chronically exposed to Cd should be observed carefully, due to the increased effect of aging on renal cortex volumes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33420688</pmid><doi>10.1007/s11356-020-12278-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Environmental science and pollution research international, 2021-05, Vol.28 (18), p.22372-22379 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Acetylglucosaminidase Aging Alkaline phosphatase Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Atrophy beta 2-Microglobulin Biomarkers blood serum Cadmium Cadmium - analysis cortex Creatinine Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Exposure - analysis Environmental Health Environmental science Female Follow-Up Studies Glucosaminidase Humans Japan Kidney - chemistry Kidneys Lesions Magnetic resonance imaging magnetism Male Neuroimaging Renal cortex Renal function Research Article Waste Water Technology Water Management Water Pollution Control Women |
| title | The relationship between cadmium exposure and renal volume in inhabitants of a cadmium-polluted area of Japan |
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