Bleeding Outcomes After Percutaneous Coronary Intervention in the Past Two Decades in Japan　― From the CREDO-Kyoto Registry Cohort-2 and Cohort-3

Bleeding Outcomes After Percutaneous Coronary Intervention in the Past Two Decades in Japan　― From the CREDO-Kyoto Registry Cohort-2 and Cohort-3

Background: Optimal intensity is unclear for P2Y12receptor blocker therapy after percutaneous coronary intervention (PCI) in real-world clinical practice.Methods and Results: From the CREDO-Kyoto Registry, the current study population consisted of 25,419 patients (Cohort-2: n=12,161 and Cohort-3: n=...

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Veröffentlicht in:Circulation Journal 2022/04/25, Vol.86(5), pp.748-759
Hauptverfasser: Natsuaki, Masahiro, Morimoto, Takeshi, Shiomi, Hiroki, Yamamoto, Ko, Yamaji, Kyohei, Watanabe, Hirotoshi, Uegaito, Takashi, Matsuda, Mitsuo, Tamura, Toshihiro, Taniguchi, Ryoji, Inoko, Moriaki, Mabuchi, Hiroshi, Takeda, Teruki, Domei, Takenori, Shirotani, Manabu, Ehara, Natsuhiko, Eizawa, Hiroshi, Ishii, Katsuhisa, Tanaka, Masaru, Inada, Tsukasa, Onodera, Tomoya, Nawada, Ryuzo, Shinoda, Eiji, Yamada, Miho, Yamamoto, Takashi, Sakai, Hiroshi, Toyofuku, Mamoru, Tamura, Takashi, Takahashi, Mamoru, Tada, Tomohisa, Sakamoto, Hiroki, Tada, Takeshi, Kaneda, Kazuhisa, Miki, Shinji, Aoyama, Takeshi, Suwa, Satoru, Sato, Yukihito, Ando, Kenji, Furukawa, Yutaka, Nakagawa, Yoshihisa, Kadota, Kazushige, Kimura, Takeshi, on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-Investigators
Format: Artikel
Sprache:eng
Schlagworte:
Cohort Studies
Coronary artery disease
Coronary Artery Disease - epidemiology
Hemorrhage - chemically induced
Hemorrhage - epidemiology
High bleeding risk
Humans
Japan - epidemiology
Percutaneous coronary intervention
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - methods
Platelet Aggregation Inhibitors - adverse effects
Registries
Risk Factors
Treatment Outcome
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Zusammenfassung:Background: Optimal intensity is unclear for P2Y12receptor blocker therapy after percutaneous coronary intervention (PCI) in real-world clinical practice.Methods and Results: From the CREDO-Kyoto Registry, the current study population consisted of 25,419 patients (Cohort-2: n=12,161 and Cohort-3: n=13,258) who underwent their first PCI. P2Y12receptor blocker therapies were reduced dose of ticlopidine (200 mg/day), and global dose of clopidogrel (75 mg/day) in 87.7% and 94.8% of patients in Cohort-2 and Cohort-3, respectively. Cumulative 3-year incidence of GUSTO moderate/severe bleeding was significantly higher in Cohort-3 than in Cohort-2 (12.1% and 9.0%, P
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-21-0526