Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006
Summary Youth with type 2 diabetes might have suboptimal peak bone mass, but it is unknown whether similar effects are evident in youth with prediabetes. Results from this study suggest that diabetes-related effects on peak bone mass likely occur before disease onset, and involve the muscle-bone uni...
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| Veröffentlicht in: | Osteoporosis international 2022-02, Vol.33 (2), p.467-474 |
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| creator | Kindler, J. Zhan, D. Sattler, E. L. P. Ishikawa, Y. Chen, X. Gallo, S. |
| description | Summary
Youth with type 2 diabetes might have suboptimal peak bone mass, but it is unknown whether similar effects are evident in youth with prediabetes. Results from this study suggest that diabetes-related effects on peak bone mass likely occur before disease onset, and involve the muscle-bone unit.
Introduction
Type 2 diabetes might adversely influence bone health around the age of peak bone mass, but it is unknown whether diabetes-related effects on areal bone mineral density (aBMD) are evident in youth with prediabetes. We compared age-related trends in aBMD and associations between lean body mass (LBM) and aBMD between children and adolescents with prediabetes vs. normal glucose regulation.
Methods
Cross-sectional analysis of data from the National Health and Nutrition Examination Survey (2005–2006) in youth ages 12–20 years (49% female, 34% black) with prediabetes (
n
= 267) and normal glucose regulation (
n
= 1664). Whole body aBMD and LBM were assessed via DXA. LBM index (LBMI) and Z-scores for aBMD and LBMI were computed.
Results
Unadjusted between-group comparisons revealed greater mean weight and LBMI Z-scores in youth with prediabetes vs. normal glucose regulation, but similar bone Z-scores between the two groups. While accounting for differences in BMI Z-score, there was a significant interaction between prediabetes status and age with respect to whole body aBMD Z-score (
P
|
| doi_str_mv | 10.1007/s00198-021-06148-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2572940170</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2572940170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1fcdb86a40328c11f07910ef626f8341bc59b0140dc055adddc5bb553c6da5db3</originalsourceid><addsrcrecordid>eNp9kc1OFjEUhhujkU_0BliQJm5cOHJOO50fdkpQTAgs1MRd02nPQMn8fLQd9Nt5D96hV2LhQ0xcuOlJ2ud9m5OHsT2ENwhQH0QAbJsCBBZQYdkU4hFbYSllIdpKPWYraGVdtCV-3WHPYryCHGrb-inbkaUSEhBW7ObdPBF3NEWfNtxPfDMv6ZJ_8_lYB3LedJQoHvJAcRlS5H2YR54uiZ-Z5OfJDPyEzJBpMzl-tqTgb6_58Xcz-ukO4Z-WcEOb11wAqF8_fuZRPWdPejNEenE_d9mX98efj06K0_MPH4_enhZW1ioV2FvXNZUpQYrGIvZ5AQTqK1H1jSyxs6rtAEtwFpQyzjmruk4paStnlOvkLnu17V2H-XqhmPToo6VhMBPNS9RC1aItAWvI6Mt_0Kt5CXnBTFVCoRCilpkSW8qGOcZAvV4HP5qw0Qj61oreWtHZir6zokUO7d9XL91I7iHyR0MG5BaI-Wm6oPD37__U_gY8FZgH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2625122273</pqid></control><display><type>article</type><title>Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kindler, J. ; Zhan, D. ; Sattler, E. L. P. ; Ishikawa, Y. ; Chen, X. ; Gallo, S.</creator><creatorcontrib>Kindler, J. ; Zhan, D. ; Sattler, E. L. P. ; Ishikawa, Y. ; Chen, X. ; Gallo, S.</creatorcontrib><description>Summary
Youth with type 2 diabetes might have suboptimal peak bone mass, but it is unknown whether similar effects are evident in youth with prediabetes. Results from this study suggest that diabetes-related effects on peak bone mass likely occur before disease onset, and involve the muscle-bone unit.
Introduction
Type 2 diabetes might adversely influence bone health around the age of peak bone mass, but it is unknown whether diabetes-related effects on areal bone mineral density (aBMD) are evident in youth with prediabetes. We compared age-related trends in aBMD and associations between lean body mass (LBM) and aBMD between children and adolescents with prediabetes vs. normal glucose regulation.
Methods
Cross-sectional analysis of data from the National Health and Nutrition Examination Survey (2005–2006) in youth ages 12–20 years (49% female, 34% black) with prediabetes (
n
= 267) and normal glucose regulation (
n
= 1664). Whole body aBMD and LBM were assessed via DXA. LBM index (LBMI) and Z-scores for aBMD and LBMI were computed.
Results
Unadjusted between-group comparisons revealed greater mean weight and LBMI Z-scores in youth with prediabetes vs. normal glucose regulation, but similar bone Z-scores between the two groups. While accounting for differences in BMI Z-score, there was a significant interaction between prediabetes status and age with respect to whole body aBMD Z-score (
P
< 0.05), such that children with prediabetes tended to have increased aBMD but adolescents and young adults with prediabetes tended have lower aBMD. Furthermore, the positive association between LBMI and whole body aBMD was moderated in youth with prediabetes (
P
< 0.001), who had slightly lower whole body aBMD for a given LBMI (
P
= 0.068). Lumbar spine bone measures did not differ between the two groups.
Conclusions
Type 2 diabetes-related threats to peak bone mass might occur prior to disease onset, therefore potentially impacting a considerable proportion of US youth.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-021-06148-2</identifier><identifier>PMID: 34523010</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Absorptiometry, Photon ; Adolescent ; Adolescents ; Adult ; Age ; Body mass index ; Bone Density ; Bone mass ; Bone mineral density ; Child ; Children ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Dual energy X-ray absorptiometry ; Endocrinology ; Female ; Glucose ; Humans ; Lean body mass ; Male ; Medicine ; Medicine & Public Health ; Nutrition Surveys ; Original Article ; Orthopedics ; Osteoporosis ; Prediabetic State - epidemiology ; Rheumatology ; Spine (lumbar) ; Young Adult ; Young adults</subject><ispartof>Osteoporosis international, 2022-02, Vol.33 (2), p.467-474</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2021</rights><rights>2021. International Osteoporosis Foundation and National Osteoporosis Foundation.</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1fcdb86a40328c11f07910ef626f8341bc59b0140dc055adddc5bb553c6da5db3</citedby><cites>FETCH-LOGICAL-c375t-1fcdb86a40328c11f07910ef626f8341bc59b0140dc055adddc5bb553c6da5db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-021-06148-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-021-06148-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34523010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kindler, J.</creatorcontrib><creatorcontrib>Zhan, D.</creatorcontrib><creatorcontrib>Sattler, E. L. P.</creatorcontrib><creatorcontrib>Ishikawa, Y.</creatorcontrib><creatorcontrib>Chen, X.</creatorcontrib><creatorcontrib>Gallo, S.</creatorcontrib><title>Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
Youth with type 2 diabetes might have suboptimal peak bone mass, but it is unknown whether similar effects are evident in youth with prediabetes. Results from this study suggest that diabetes-related effects on peak bone mass likely occur before disease onset, and involve the muscle-bone unit.
Introduction
Type 2 diabetes might adversely influence bone health around the age of peak bone mass, but it is unknown whether diabetes-related effects on areal bone mineral density (aBMD) are evident in youth with prediabetes. We compared age-related trends in aBMD and associations between lean body mass (LBM) and aBMD between children and adolescents with prediabetes vs. normal glucose regulation.
Methods
Cross-sectional analysis of data from the National Health and Nutrition Examination Survey (2005–2006) in youth ages 12–20 years (49% female, 34% black) with prediabetes (
n
= 267) and normal glucose regulation (
n
= 1664). Whole body aBMD and LBM were assessed via DXA. LBM index (LBMI) and Z-scores for aBMD and LBMI were computed.
Results
Unadjusted between-group comparisons revealed greater mean weight and LBMI Z-scores in youth with prediabetes vs. normal glucose regulation, but similar bone Z-scores between the two groups. While accounting for differences in BMI Z-score, there was a significant interaction between prediabetes status and age with respect to whole body aBMD Z-score (
P
< 0.05), such that children with prediabetes tended to have increased aBMD but adolescents and young adults with prediabetes tended have lower aBMD. Furthermore, the positive association between LBMI and whole body aBMD was moderated in youth with prediabetes (
P
< 0.001), who had slightly lower whole body aBMD for a given LBMI (
P
= 0.068). Lumbar spine bone measures did not differ between the two groups.
Conclusions
Type 2 diabetes-related threats to peak bone mass might occur prior to disease onset, therefore potentially impacting a considerable proportion of US youth.</description><subject>Absorptiometry, Photon</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Age</subject><subject>Body mass index</subject><subject>Bone Density</subject><subject>Bone mass</subject><subject>Bone mineral density</subject><subject>Child</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Glucose</subject><subject>Humans</subject><subject>Lean body mass</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nutrition Surveys</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Prediabetic State - epidemiology</subject><subject>Rheumatology</subject><subject>Spine (lumbar)</subject><subject>Young Adult</subject><subject>Young adults</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1OFjEUhhujkU_0BliQJm5cOHJOO50fdkpQTAgs1MRd02nPQMn8fLQd9Nt5D96hV2LhQ0xcuOlJ2ud9m5OHsT2ENwhQH0QAbJsCBBZQYdkU4hFbYSllIdpKPWYraGVdtCV-3WHPYryCHGrb-inbkaUSEhBW7ObdPBF3NEWfNtxPfDMv6ZJ_8_lYB3LedJQoHvJAcRlS5H2YR54uiZ-Z5OfJDPyEzJBpMzl-tqTgb6_58Xcz-ukO4Z-WcEOb11wAqF8_fuZRPWdPejNEenE_d9mX98efj06K0_MPH4_enhZW1ioV2FvXNZUpQYrGIvZ5AQTqK1H1jSyxs6rtAEtwFpQyzjmruk4paStnlOvkLnu17V2H-XqhmPToo6VhMBPNS9RC1aItAWvI6Mt_0Kt5CXnBTFVCoRCilpkSW8qGOcZAvV4HP5qw0Qj61oreWtHZir6zokUO7d9XL91I7iHyR0MG5BaI-Wm6oPD37__U_gY8FZgH</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Kindler, J.</creator><creator>Zhan, D.</creator><creator>Sattler, E. L. P.</creator><creator>Ishikawa, Y.</creator><creator>Chen, X.</creator><creator>Gallo, S.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006</title><author>Kindler, J. ; Zhan, D. ; Sattler, E. L. P. ; Ishikawa, Y. ; Chen, X. ; Gallo, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1fcdb86a40328c11f07910ef626f8341bc59b0140dc055adddc5bb553c6da5db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Absorptiometry, Photon</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Age</topic><topic>Body mass index</topic><topic>Bone Density</topic><topic>Bone mass</topic><topic>Bone mineral density</topic><topic>Child</topic><topic>Children</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Glucose</topic><topic>Humans</topic><topic>Lean body mass</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nutrition Surveys</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Prediabetic State - epidemiology</topic><topic>Rheumatology</topic><topic>Spine (lumbar)</topic><topic>Young Adult</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kindler, J.</creatorcontrib><creatorcontrib>Zhan, D.</creatorcontrib><creatorcontrib>Sattler, E. L. P.</creatorcontrib><creatorcontrib>Ishikawa, Y.</creatorcontrib><creatorcontrib>Chen, X.</creatorcontrib><creatorcontrib>Gallo, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kindler, J.</au><au>Zhan, D.</au><au>Sattler, E. L. P.</au><au>Ishikawa, Y.</au><au>Chen, X.</au><au>Gallo, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>33</volume><issue>2</issue><spage>467</spage><epage>474</epage><pages>467-474</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
Youth with type 2 diabetes might have suboptimal peak bone mass, but it is unknown whether similar effects are evident in youth with prediabetes. Results from this study suggest that diabetes-related effects on peak bone mass likely occur before disease onset, and involve the muscle-bone unit.
Introduction
Type 2 diabetes might adversely influence bone health around the age of peak bone mass, but it is unknown whether diabetes-related effects on areal bone mineral density (aBMD) are evident in youth with prediabetes. We compared age-related trends in aBMD and associations between lean body mass (LBM) and aBMD between children and adolescents with prediabetes vs. normal glucose regulation.
Methods
Cross-sectional analysis of data from the National Health and Nutrition Examination Survey (2005–2006) in youth ages 12–20 years (49% female, 34% black) with prediabetes (
n
= 267) and normal glucose regulation (
n
= 1664). Whole body aBMD and LBM were assessed via DXA. LBM index (LBMI) and Z-scores for aBMD and LBMI were computed.
Results
Unadjusted between-group comparisons revealed greater mean weight and LBMI Z-scores in youth with prediabetes vs. normal glucose regulation, but similar bone Z-scores between the two groups. While accounting for differences in BMI Z-score, there was a significant interaction between prediabetes status and age with respect to whole body aBMD Z-score (
P
< 0.05), such that children with prediabetes tended to have increased aBMD but adolescents and young adults with prediabetes tended have lower aBMD. Furthermore, the positive association between LBMI and whole body aBMD was moderated in youth with prediabetes (
P
< 0.001), who had slightly lower whole body aBMD for a given LBMI (
P
= 0.068). Lumbar spine bone measures did not differ between the two groups.
Conclusions
Type 2 diabetes-related threats to peak bone mass might occur prior to disease onset, therefore potentially impacting a considerable proportion of US youth.</abstract><cop>London</cop><pub>Springer London</pub><pmid>34523010</pmid><doi>10.1007/s00198-021-06148-2</doi><tpages>8</tpages></addata></record> |
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| issn | 0937-941X 1433-2965 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Absorptiometry, Photon Adolescent Adolescents Adult Age Body mass index Bone Density Bone mass Bone mineral density Child Children Cross-Sectional Studies Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Dual energy X-ray absorptiometry Endocrinology Female Glucose Humans Lean body mass Male Medicine Medicine & Public Health Nutrition Surveys Original Article Orthopedics Osteoporosis Prediabetic State - epidemiology Rheumatology Spine (lumbar) Young Adult Young adults |
| title | Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006 |
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