Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis

The activation of innate immune system is essential for the pathogenesis of nonalcoholic steatohepatitis (NASH). Among pattern recognition receptors, it is well-characterized that toll-like receptors (TLRs) are deeply involved in the development of NASH to reflect exposure of the liver to gut-driven...

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Veröffentlicht in:	Inflammation 2022-02, Vol.45 (1), p.343-355
Hauptverfasser:	Kawaguchi, Shogo, Sakuraba, Hirotake, Horiuchi, Momone, Ding, Jiangli, Matsumiya, Tomoh, Seya, Kazuhiko, Iino, Chikara, Endo, Tetsu, Kikuchi, Hidezumi, Yoshida, Shukuko, Hiraga, Hiroto, Fukuda, Shinsaku, Imaizumi, Tadaatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino acids Animal models Animals Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Biopsy Bone marrow CD11b antigen Endotoxins Fatty liver Female Gene expression High fat diet Humans Immune system Immunofluorescence Immunology Innate immunity Interferon-Induced Helicase, IFIH1 - metabolism Internal Medicine Lipopolysaccharides Liver Liver - immunology Liver - metabolism Liver diseases Macrophages Macrophages - metabolism Male Melanoma Mice Mice, Inbred C57BL Middle Aged Non-alcoholic Fatty Liver Disease - immunology Non-alcoholic Fatty Liver Disease - metabolism Original Article Pathology Pattern recognition receptors Pharmacology/Toxicology Retinoic acid Rheumatology THP-1 Cells Toll-like receptors Western blotting
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