Glial IL-33 signaling through an ST2-to-CXCL12 pathway in the spinal cord contributes to morphine-induced hyperalgesia and tolerance

Morphine and other opiates are highly effective for treating moderate to severe pain. However, morphine-induced hyperalgesia and analgesic tolerance prevent durable efficacy in patients. Here, we investigated the underlying molecular mechanisms of this phenomenon. We found that repeated subcutaneous...

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Veröffentlicht in:	Science signaling 2021-09, Vol.14 (699), p.eabe3773-eabe3773
Hauptverfasser:	Hu, Xue-Ming, Yang, Wei, Zhang, Meng-Ting, Du, Li-Xia, Tian, Jia-He, Zhu, Jian-Yu, Chen, Yu, Hai, Feng, Liu, Shen-Bin, Mao-Ying, Qi-Liang, Chu, Yu-Xia, Zhou, Hong, Wang, Yan-Qing, Mi, Wen-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Astrocytes Autocrine signalling Chemokine receptors Chemokines Chronic pain CXCL12 protein CXCR4 protein Cytokines Hyperalgesia Hyperalgesia - chemically induced Interleukin-33 Interleukins Kinases Molecular modelling Morphine Morphine - adverse effects Narcotics Oligodendrocytes Opioids Pain Pain management Pain perception Paracrine signalling Patients Pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, Interleukin-1 Signal transduction Signaling Spinal Cord Spine Synaptic transmission TRAF6 protein
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