Effect of memantine on the survival of an ischemic random skin flap and the underlying mechanism

Skin flap transplantation is a common wound repair method in orthopedic surgery, but skin flap necrosis remains problematic. Memantine, an excitatory amino acid receptor antagonist, is currently used in the treatment of moderate to severe Alzheimer's disease, due to its ability to promote angio...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-11, Vol.143, p.112163-112163, Article 112163
Hauptverfasser:	Fan, Weijian, Liu, Zhenhua, Chen, Jianpeng, Liu, Shaodong, Chen, Tingxiang, Li, Zhijie, Lin, Dingsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inducing Agents - pharmacology Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Disease Models, Animal Graft Survival - drug effects Inflammation Mediators - metabolism Lipid Peroxidation - drug effects Male MAPK Memantine Memantine - pharmacology Neovascularization, Physiologic - drug effects NF-kB Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control Skin - blood supply Skin - drug effects Skin - metabolism Skin - pathology Skin flap Skin Transplantation - adverse effects Surgical Flaps - blood supply Surgical Flaps - pathology Up-Regulation Vascular Endothelial Growth Factor A - metabolism VEGF
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