Fenofibrate inhibits hypoxia‐inducible factor‐1 alpha and carbonic anhydrase expression through activation of AMP‐activated protein kinase/HO‐1/Sirt1 pathway in glioblastoma cells

Cancer and its associated conditions have significant impacts on public health at many levels worldwide, and cancer is the leading cause of death among adults. Peroxisome proliferator‐activated receptor α (PPARα)‐specific agonists, fibrates, have been approved by the Food and Drug Administration for...

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Veröffentlicht in:	Environmental toxicology 2021-12, Vol.36 (12), p.2551-2561
Hauptverfasser:	Lin, Chingju, Lai, Sheng‐Wei, Shen, Ching‐Kai, Chen, Chao‐Wei, Tsai, Cheng‐Fang, Liu, Yu‐Shu, Lu, Dah‐Yuu, Huang, Bor‐Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated carbon Agonists Brain cancer Cancer Carbonic anhydrase Carbonic anhydrases Cell activation Cycloheximide Deacetylation Fenofibrate Glioblastoma Glioblastoma cells HIF‐1α HO‐1 Hyperlipidemia Hypoxia Immunosurveillance Inhibitors Kinases Neoplasms Proteasome inhibitors Protein biosynthesis Protein kinase Protein synthesis Proteins Public health Receptors SIRT1 SIRT1 protein Tumors
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