Platelet features allow to differentiate immune thrombocytopenia from inherited thrombocytopenia
Immune thrombocytopenia (ITP) is an acquired bleeding disorder, for which no specific diagnostic test exists. Inherited thrombocytopenia (IT) can mimic ITP and lead to unappropriated management with significant morbidity. Here, in small cohorts of these two disorders, we explored whether platelet si...
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| Veröffentlicht in: | Annals of hematology 2021-11, Vol.100 (11), p.2677-2682 |
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| creator | Bonnard, Guillaume Babuty, Antoine Collot, Romain Costes, Domitille Drillaud, Nicolas Eveillard, Marion Néel, Antoine Espitia, Alexandra Masseau, Agathe Wahbi, Anaïs Hamidou, Mohamed Béné, Marie C. Fouassier, Marc |
| description | Immune thrombocytopenia (ITP) is an acquired bleeding disorder, for which no specific diagnostic test exists. Inherited thrombocytopenia (IT) can mimic ITP and lead to unappropriated management with significant morbidity. Here, in small cohorts of these two disorders, we explored whether platelet sialylation and platelet activation could allow to discriminate the two conditions. We also aimed to confirm the value of immature platelet counts in this discrimination. Platelet sialylation and the expression level of P-selectin were assessed by multiparameter flow cytometry. Immature platelets were estimated on a Sysmex XN 9000 analyzer. No significant difference in platelet sialylation was observed between ITP and IT. Contrarily, platelet activation was significantly higher in ITP patients (
p
= 0.008). The immature platelet fraction, as previously demonstrated, was significantly lower in the ITP group compared to the IT group (
p
= 0.014). That statistical significance was achieved in this small pilot study suggests that the two easily available assays of immature platelet count and P-selectin expression could help physicians to reach the proper diagnosis in complex cases of thrombocytopenia. |
| doi_str_mv | 10.1007/s00277-021-04651-4 |
| format | Article |
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p
= 0.008). The immature platelet fraction, as previously demonstrated, was significantly lower in the ITP group compared to the IT group (
p
= 0.014). That statistical significance was achieved in this small pilot study suggests that the two easily available assays of immature platelet count and P-selectin expression could help physicians to reach the proper diagnosis in complex cases of thrombocytopenia.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-021-04651-4</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Hematology ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Thrombocytopenia</subject><ispartof>Annals of hematology, 2021-11, Vol.100 (11), p.2677-2682</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-c740a6c12f489b29f2e0d3b1d40ddd374a050a3a4ab9c820d8d80349b00db2833</citedby><cites>FETCH-LOGICAL-c352t-c740a6c12f489b29f2e0d3b1d40ddd374a050a3a4ab9c820d8d80349b00db2833</cites><orcidid>0000-0001-5717-4720</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-021-04651-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-021-04651-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Bonnard, Guillaume</creatorcontrib><creatorcontrib>Babuty, Antoine</creatorcontrib><creatorcontrib>Collot, Romain</creatorcontrib><creatorcontrib>Costes, Domitille</creatorcontrib><creatorcontrib>Drillaud, Nicolas</creatorcontrib><creatorcontrib>Eveillard, Marion</creatorcontrib><creatorcontrib>Néel, Antoine</creatorcontrib><creatorcontrib>Espitia, Alexandra</creatorcontrib><creatorcontrib>Masseau, Agathe</creatorcontrib><creatorcontrib>Wahbi, Anaïs</creatorcontrib><creatorcontrib>Hamidou, Mohamed</creatorcontrib><creatorcontrib>Béné, Marie C.</creatorcontrib><creatorcontrib>Fouassier, Marc</creatorcontrib><title>Platelet features allow to differentiate immune thrombocytopenia from inherited thrombocytopenia</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><description>Immune thrombocytopenia (ITP) is an acquired bleeding disorder, for which no specific diagnostic test exists. Inherited thrombocytopenia (IT) can mimic ITP and lead to unappropriated management with significant morbidity. Here, in small cohorts of these two disorders, we explored whether platelet sialylation and platelet activation could allow to discriminate the two conditions. We also aimed to confirm the value of immature platelet counts in this discrimination. Platelet sialylation and the expression level of P-selectin were assessed by multiparameter flow cytometry. Immature platelets were estimated on a Sysmex XN 9000 analyzer. No significant difference in platelet sialylation was observed between ITP and IT. Contrarily, platelet activation was significantly higher in ITP patients (
p
= 0.008). The immature platelet fraction, as previously demonstrated, was significantly lower in the ITP group compared to the IT group (
p
= 0.014). 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Inherited thrombocytopenia (IT) can mimic ITP and lead to unappropriated management with significant morbidity. Here, in small cohorts of these two disorders, we explored whether platelet sialylation and platelet activation could allow to discriminate the two conditions. We also aimed to confirm the value of immature platelet counts in this discrimination. Platelet sialylation and the expression level of P-selectin were assessed by multiparameter flow cytometry. Immature platelets were estimated on a Sysmex XN 9000 analyzer. No significant difference in platelet sialylation was observed between ITP and IT. Contrarily, platelet activation was significantly higher in ITP patients (
p
= 0.008). The immature platelet fraction, as previously demonstrated, was significantly lower in the ITP group compared to the IT group (
p
= 0.014). That statistical significance was achieved in this small pilot study suggests that the two easily available assays of immature platelet count and P-selectin expression could help physicians to reach the proper diagnosis in complex cases of thrombocytopenia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00277-021-04651-4</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5717-4720</orcidid></addata></record> |
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| subjects | Hematology Medicine Medicine & Public Health Oncology Original Article Thrombocytopenia |
| title | Platelet features allow to differentiate immune thrombocytopenia from inherited thrombocytopenia |
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