Abnormal hippocampal substructure volume in insomnia disorder
To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that hippocampal function can be mapped to anatomically defined substructures, the hippocampal substructure volume can be examined in deta...
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| Veröffentlicht in: | Brain imaging and behavior 2022-04, Vol.16 (2), p.672-679 |
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| creator | Chen, Longmao Shao, Ziqiang Lei, Wangrui Xu, Yan Liu, Shuang Zhang, Min Wang, Shicong Wen, Xinwen Yu, Dahua Yuan, Kai |
| description | To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that hippocampal function can be mapped to anatomically defined substructures, the hippocampal substructure volume can be examined in detail at present. In this study, we examined the volumes of hippocampal substructures between IDs and healthy controls (HC) to accurately find hippocampal markers of ID. First, we used the automated hippocampal substructure module in FreeSurfer6.0 to inspect T1-weighted magnetic resonance images between 22 IDs and 30 HC. Then, 12 hippocampal substructures were computed. Volumetric assessment was performed at the hippocampal substructure level between groups. Our study revealed significant reduced volume of the bilateral fimbria in IDs compared with HC (
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| doi_str_mv | 10.1007/s11682-021-00540-6 |
| format | Article |
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p
< 0.05/12, Bonferroni corrected), although there was no difference in the total volume of hippocampus. In addition, the correlation analysis showed that the total hippocampal volume of the left hemisphere was negatively correlated with Pittsburgh Sleep Quality Index (PSQI) scores. With regard to hippocampal substructure results, negative correlations were detected between bilateral fimbria volume and clinical variables (i.e., PSQI, SDS, and SAS) in all subjects. Taken together, we revealed marked differences in the volume of the hippocampal substructure between IDs and HC, which provided a more accurate structural imaging marker for the pathological of ID.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-021-00540-6</identifier><identifier>PMID: 34518976</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Correlation analysis ; Fornix ; Hemispheric laterality ; Hippocampus ; Hippocampus - pathology ; Humans ; Insomnia ; Magnetic Resonance Imaging ; Markers ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Psychiatry ; Sleep disorders ; Sleep Initiation and Maintenance Disorders - pathology</subject><ispartof>Brain imaging and behavior, 2022-04, Vol.16 (2), p.672-679</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-219e2aedbd69ad89e488e270eea53b1ab26b10d2f821674421f16f958a5485333</citedby><cites>FETCH-LOGICAL-c375t-219e2aedbd69ad89e488e270eea53b1ab26b10d2f821674421f16f958a5485333</cites><orcidid>0000-0002-3098-1124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-021-00540-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-021-00540-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34518976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Longmao</creatorcontrib><creatorcontrib>Shao, Ziqiang</creatorcontrib><creatorcontrib>Lei, Wangrui</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Liu, Shuang</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Wang, Shicong</creatorcontrib><creatorcontrib>Wen, Xinwen</creatorcontrib><creatorcontrib>Yu, Dahua</creatorcontrib><creatorcontrib>Yuan, Kai</creatorcontrib><title>Abnormal hippocampal substructure volume in insomnia disorder</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><addtitle>Brain Imaging Behav</addtitle><description>To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that hippocampal function can be mapped to anatomically defined substructures, the hippocampal substructure volume can be examined in detail at present. In this study, we examined the volumes of hippocampal substructures between IDs and healthy controls (HC) to accurately find hippocampal markers of ID. First, we used the automated hippocampal substructure module in FreeSurfer6.0 to inspect T1-weighted magnetic resonance images between 22 IDs and 30 HC. Then, 12 hippocampal substructures were computed. Volumetric assessment was performed at the hippocampal substructure level between groups. Our study revealed significant reduced volume of the bilateral fimbria in IDs compared with HC (
p
< 0.05/12, Bonferroni corrected), although there was no difference in the total volume of hippocampus. In addition, the correlation analysis showed that the total hippocampal volume of the left hemisphere was negatively correlated with Pittsburgh Sleep Quality Index (PSQI) scores. With regard to hippocampal substructure results, negative correlations were detected between bilateral fimbria volume and clinical variables (i.e., PSQI, SDS, and SAS) in all subjects. Taken together, we revealed marked differences in the volume of the hippocampal substructure between IDs and HC, which provided a more accurate structural imaging marker for the pathological of ID.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Correlation analysis</subject><subject>Fornix</subject><subject>Hemispheric laterality</subject><subject>Hippocampus</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Insomnia</subject><subject>Magnetic Resonance Imaging</subject><subject>Markers</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Psychiatry</subject><subject>Sleep disorders</subject><subject>Sleep Initiation and Maintenance Disorders - pathology</subject><issn>1931-7557</issn><issn>1931-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuXaiZpkubgYVn8ggUveg5pm2qXtqlJI_jvzVpdwYMwMAN55s3wIHQK-BIwFlcegOckxQRSjFmGU76H5iAppIJxtr-bmZihI-83WyiXcIhmNGOQS8Hn6HpZ9NZ1uk1em2Gwpe6GOPtQ-NGFcgzOJO-2DZ1Jmj6Wt13f6KRqvHWVccfooNatNyfffYGeb2-eVvfp-vHuYbVcpyUVbEwJSEO0qYqKS13l0mR5bojAxmhGC9AF4QXgitQ5AS6yjEANvJYs1_FgRildoIspd3D2LRg_qq7xpWlb3RsbvCJMEEYYz2REz_-gGxtcH69ThDMMmEY3kSITVTrrvTO1GlzTafehAKutXDXJVVGu-pKreFw6-44ORWeq3cqPzQjQCfDxqX8x7vfvf2I_AR2ag6c</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Chen, Longmao</creator><creator>Shao, Ziqiang</creator><creator>Lei, Wangrui</creator><creator>Xu, Yan</creator><creator>Liu, Shuang</creator><creator>Zhang, Min</creator><creator>Wang, Shicong</creator><creator>Wen, Xinwen</creator><creator>Yu, Dahua</creator><creator>Yuan, Kai</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3098-1124</orcidid></search><sort><creationdate>20220401</creationdate><title>Abnormal hippocampal substructure volume in insomnia disorder</title><author>Chen, Longmao ; Shao, Ziqiang ; Lei, Wangrui ; Xu, Yan ; Liu, Shuang ; Zhang, Min ; Wang, Shicong ; Wen, Xinwen ; Yu, Dahua ; Yuan, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-219e2aedbd69ad89e488e270eea53b1ab26b10d2f821674421f16f958a5485333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Correlation analysis</topic><topic>Fornix</topic><topic>Hemispheric laterality</topic><topic>Hippocampus</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Insomnia</topic><topic>Magnetic Resonance Imaging</topic><topic>Markers</topic><topic>Neuropsychology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Research</topic><topic>Psychiatry</topic><topic>Sleep disorders</topic><topic>Sleep Initiation and Maintenance Disorders - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Longmao</creatorcontrib><creatorcontrib>Shao, Ziqiang</creatorcontrib><creatorcontrib>Lei, Wangrui</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Liu, Shuang</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Wang, Shicong</creatorcontrib><creatorcontrib>Wen, Xinwen</creatorcontrib><creatorcontrib>Yu, Dahua</creatorcontrib><creatorcontrib>Yuan, Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain imaging and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Longmao</au><au>Shao, Ziqiang</au><au>Lei, Wangrui</au><au>Xu, Yan</au><au>Liu, Shuang</au><au>Zhang, Min</au><au>Wang, Shicong</au><au>Wen, Xinwen</au><au>Yu, Dahua</au><au>Yuan, Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal hippocampal substructure volume in insomnia disorder</atitle><jtitle>Brain imaging and behavior</jtitle><stitle>Brain Imaging and Behavior</stitle><addtitle>Brain Imaging Behav</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>16</volume><issue>2</issue><spage>672</spage><epage>679</epage><pages>672-679</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that hippocampal function can be mapped to anatomically defined substructures, the hippocampal substructure volume can be examined in detail at present. In this study, we examined the volumes of hippocampal substructures between IDs and healthy controls (HC) to accurately find hippocampal markers of ID. First, we used the automated hippocampal substructure module in FreeSurfer6.0 to inspect T1-weighted magnetic resonance images between 22 IDs and 30 HC. Then, 12 hippocampal substructures were computed. Volumetric assessment was performed at the hippocampal substructure level between groups. Our study revealed significant reduced volume of the bilateral fimbria in IDs compared with HC (
p
< 0.05/12, Bonferroni corrected), although there was no difference in the total volume of hippocampus. In addition, the correlation analysis showed that the total hippocampal volume of the left hemisphere was negatively correlated with Pittsburgh Sleep Quality Index (PSQI) scores. With regard to hippocampal substructure results, negative correlations were detected between bilateral fimbria volume and clinical variables (i.e., PSQI, SDS, and SAS) in all subjects. Taken together, we revealed marked differences in the volume of the hippocampal substructure between IDs and HC, which provided a more accurate structural imaging marker for the pathological of ID.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34518976</pmid><doi>10.1007/s11682-021-00540-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3098-1124</orcidid></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Correlation analysis Fornix Hemispheric laterality Hippocampus Hippocampus - pathology Humans Insomnia Magnetic Resonance Imaging Markers Neuropsychology Neuroradiology Neurosciences Original Research Psychiatry Sleep disorders Sleep Initiation and Maintenance Disorders - pathology |
| title | Abnormal hippocampal substructure volume in insomnia disorder |
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