Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease

Fifteen chalcone derivatives 3a–3o were synthesized, and evaluated as multifunctional agents against Alzheimer's disease. In vitro studies revealed that these compounds inhibited self‐induced Aβ1‐42 aggregation effectively ranged from 45.9–94.5 % at 20 μM, and acted as potential antioxidants. T...

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Veröffentlicht in:	Chemistry & biodiversity 2021-11, Vol.18 (11), p.e2100341-n/a
Hauptverfasser:	Wang, Xiao‐Qin, Zhou, Lu‐Yi, Tan, Ren‐Xian, Liang, Guo‐Peng, Fang, Si‐Xian, Li, Wei, Xie, Mei, Wen, Yu‐Hao, Wu, Jia‐Qiang, Chen, Yi‐Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - metabolism Animals Antioxidants Aβ aggregation Cell Survival - drug effects chalcone Chalcones - chemical synthesis Chalcones - chemistry Chalcones - pharmacology Chelation Copper Copper - pharmacology Cytotoxicity Drug Design Fibrils Humans Memory Disorders - chemically induced Memory Disorders - drug therapy metal chelating Mice multifunctional Neurodegenerative diseases Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Peptide Fragments - antagonists & inhibitors Peptide Fragments - metabolism Protein Aggregates - drug effects Scopolamine Toxicity Tumor Cells, Cultured
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