KAHRP dynamically relocalizes to remodeled actin junctions and associates with knob spirals in Plasmodium falciparum‐infected erythrocytes

The knob‐associated histidine‐rich protein (KAHRP) plays a pivotal role in the pathophysiology of Plasmodium falciparum malaria by forming membrane protrusions in infected erythrocytes, which anchor parasite‐encoded adhesins to the membrane skeleton. The resulting sequestration of parasitized erythr...

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Veröffentlicht in:	Molecular microbiology 2022-02, Vol.117 (2), p.274-292
Hauptverfasser:	Sanchez, Cecilia P., Patra, Pintu, Chang, Shih‐Ying Scott, Karathanasis, Christos, Hanebutte, Lukas, Kilian, Nicole, Cyrklaff, Marek, Heilemann, Mike, Schwarz, Ulrich S., Kudryashev, Mikhail, Lanzer, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adhesins ankyrin Ankyrins Dynamic models erythrocyte Erythrocytes Histidine Knobs Localization Malaria Membranes Microscopy Microvasculature Parasites Plasmodium falciparum Scaffolds Skeleton Spirals Vector-borne diseases Virulence virulence factor Virulence factors
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