Association between angiotensin‐converting enzyme gene insertion deletion polymorphism and androgenetic alopecia susceptibility among Egyptian patients: A preliminary case‐controlled study
Background Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin‐converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflamma...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2022-06, Vol.21 (6), p.2629-2634 |
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| container_title | Journal of cosmetic dermatology |
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| creator | Mustafa, Amany Ibrahim Ibrahim, Samah Ezzat Gohary, Yasser Mostafa Al‐Husseini, Naglaa Fathy Fawzy, Eman El‐Shimi, Ola Samir |
| description | Background
Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin‐converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility.
Objectives
In this work, we aimed at exploring the association of ACE gene I/D polymorphism in AGA susceptibility in a group of Egyptian patients.
Methods
This study included 100 AGA patients, and 100 apparently healthy controls. The ACE gene I/D polymorphism was analyzed by polymerase chain reaction.
Results
The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (p |
| doi_str_mv | 10.1111/jocd.14434 |
| format | Article |
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Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin‐converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility.
Objectives
In this work, we aimed at exploring the association of ACE gene I/D polymorphism in AGA susceptibility in a group of Egyptian patients.
Methods
This study included 100 AGA patients, and 100 apparently healthy controls. The ACE gene I/D polymorphism was analyzed by polymerase chain reaction.
Results
The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (p < 0.05 each). Positive family history and ACE gene I/D polymorphism were considered AGA susceptibility predictors in both uni‐ and multivariable analyses [p < 0.05 each (OR (95% CI)] on applying logistic regression analysis for risk factors prediction.
Conclusions
This study highlights the possible contribution of the suspected genetic polymorphism as a susceptibility indicator for AGA development in the examined group of patients.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.14434</identifier><language>eng</language><subject>androgenetic alopecia ; insertion/deletion ; polymorphism</subject><ispartof>Journal of cosmetic dermatology, 2022-06, Vol.21 (6), p.2629-2634</ispartof><rights>2021 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3064-1d84ba76e99dd4d4ca19c94e41b83459b8ceffc8dd33d0332a88fc81604f10b23</citedby><cites>FETCH-LOGICAL-c3064-1d84ba76e99dd4d4ca19c94e41b83459b8ceffc8dd33d0332a88fc81604f10b23</cites><orcidid>0000-0001-8276-8352 ; 0000-0003-3877-5787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.14434$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.14434$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Mustafa, Amany Ibrahim</creatorcontrib><creatorcontrib>Ibrahim, Samah Ezzat</creatorcontrib><creatorcontrib>Gohary, Yasser Mostafa</creatorcontrib><creatorcontrib>Al‐Husseini, Naglaa Fathy</creatorcontrib><creatorcontrib>Fawzy, Eman</creatorcontrib><creatorcontrib>El‐Shimi, Ola Samir</creatorcontrib><title>Association between angiotensin‐converting enzyme gene insertion deletion polymorphism and androgenetic alopecia susceptibility among Egyptian patients: A preliminary case‐controlled study</title><title>Journal of cosmetic dermatology</title><description>Background
Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin‐converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility.
Objectives
In this work, we aimed at exploring the association of ACE gene I/D polymorphism in AGA susceptibility in a group of Egyptian patients.
Methods
This study included 100 AGA patients, and 100 apparently healthy controls. The ACE gene I/D polymorphism was analyzed by polymerase chain reaction.
Results
The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (p < 0.05 each). Positive family history and ACE gene I/D polymorphism were considered AGA susceptibility predictors in both uni‐ and multivariable analyses [p < 0.05 each (OR (95% CI)] on applying logistic regression analysis for risk factors prediction.
Conclusions
This study highlights the possible contribution of the suspected genetic polymorphism as a susceptibility indicator for AGA development in the examined group of patients.</description><subject>androgenetic alopecia</subject><subject>insertion/deletion</subject><subject>polymorphism</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU1O9DAMhisEEr8bTpAl-qSBpMnMtOxGw7-Q2MC6ShN3CEqTEmdAZcUROBJn4SSk9BNLIkVxrMevbb1ZdsjoMUvn5MkrfcyE4GIj22Fizic5m003f2NOt7NdxCdK2bxk053sc4HolZHReEdqiK8Ajki3Mj6CQ-O-3j-Udy8QonErAu6tb4GswAExDodsKtNg4SfovO1bH7pHg20S0cMNfqCjUURa30FqRXCNCrpoamNN7IlsfZI-X_UpJZNImgVcxFOyIF0Aa1rjZOiJkgjjNDF4a0ETjGvd72dbjbQIB__fvezh4vx-eTW5vbu8Xi5uJ4rTmZgwXYhazmdQlloLLZRkpSoFCFYXXEzLulDQNKrQmnNNOc9lUaQvm1HRMFrnfC87GnW74J_XgLFqTVrDWunAr7HKp3NW5iXlNKH_RlQFjxigqbpg2rRDxWg12FQNNlU_NiWYjfCrsdD_QVY3d8uzseYbrIGe1A</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Mustafa, Amany Ibrahim</creator><creator>Ibrahim, Samah Ezzat</creator><creator>Gohary, Yasser Mostafa</creator><creator>Al‐Husseini, Naglaa Fathy</creator><creator>Fawzy, Eman</creator><creator>El‐Shimi, Ola Samir</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8276-8352</orcidid><orcidid>https://orcid.org/0000-0003-3877-5787</orcidid></search><sort><creationdate>202206</creationdate><title>Association between angiotensin‐converting enzyme gene insertion deletion polymorphism and androgenetic alopecia susceptibility among Egyptian patients: A preliminary case‐controlled study</title><author>Mustafa, Amany Ibrahim ; Ibrahim, Samah Ezzat ; Gohary, Yasser Mostafa ; Al‐Husseini, Naglaa Fathy ; Fawzy, Eman ; El‐Shimi, Ola Samir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3064-1d84ba76e99dd4d4ca19c94e41b83459b8ceffc8dd33d0332a88fc81604f10b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>androgenetic alopecia</topic><topic>insertion/deletion</topic><topic>polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mustafa, Amany Ibrahim</creatorcontrib><creatorcontrib>Ibrahim, Samah Ezzat</creatorcontrib><creatorcontrib>Gohary, Yasser Mostafa</creatorcontrib><creatorcontrib>Al‐Husseini, Naglaa Fathy</creatorcontrib><creatorcontrib>Fawzy, Eman</creatorcontrib><creatorcontrib>El‐Shimi, Ola Samir</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mustafa, Amany Ibrahim</au><au>Ibrahim, Samah Ezzat</au><au>Gohary, Yasser Mostafa</au><au>Al‐Husseini, Naglaa Fathy</au><au>Fawzy, Eman</au><au>El‐Shimi, Ola Samir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between angiotensin‐converting enzyme gene insertion deletion polymorphism and androgenetic alopecia susceptibility among Egyptian patients: A preliminary case‐controlled study</atitle><jtitle>Journal of cosmetic dermatology</jtitle><date>2022-06</date><risdate>2022</risdate><volume>21</volume><issue>6</issue><spage>2629</spage><epage>2634</epage><pages>2629-2634</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Background
Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin‐converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility.
Objectives
In this work, we aimed at exploring the association of ACE gene I/D polymorphism in AGA susceptibility in a group of Egyptian patients.
Methods
This study included 100 AGA patients, and 100 apparently healthy controls. The ACE gene I/D polymorphism was analyzed by polymerase chain reaction.
Results
The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (p < 0.05 each). Positive family history and ACE gene I/D polymorphism were considered AGA susceptibility predictors in both uni‐ and multivariable analyses [p < 0.05 each (OR (95% CI)] on applying logistic regression analysis for risk factors prediction.
Conclusions
This study highlights the possible contribution of the suspected genetic polymorphism as a susceptibility indicator for AGA development in the examined group of patients.</abstract><doi>10.1111/jocd.14434</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8276-8352</orcidid><orcidid>https://orcid.org/0000-0003-3877-5787</orcidid></addata></record> |
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| ispartof | Journal of cosmetic dermatology, 2022-06, Vol.21 (6), p.2629-2634 |
| issn | 1473-2130 1473-2165 |
| language | eng |
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| source | Wiley Journals |
| subjects | androgenetic alopecia insertion/deletion polymorphism |
| title | Association between angiotensin‐converting enzyme gene insertion deletion polymorphism and androgenetic alopecia susceptibility among Egyptian patients: A preliminary case‐controlled study |
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